{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:39:11Z","timestamp":1779403151351,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>In this paper, we investigate how distribution shift affects model generalizability in medical time-series from intensive care. We define clinically relevant domain adaptation scenarios for predicting hypotension and hypoxemia using the MIMIC-III Matched Waveform Database v1.0. Distribution shift is quantified via the Kolmogorov\u2013Smirnov test (KS) applied to an interpretable, lower-dimensional data representation. Our results highlight the challenges of measuring covariate, prior probability, and semantic shifts in non-stationary multivariate time series. We observed linear correlation (0.74 and 0.99) between KS(source train, target) - KS(source train, source test) and RMSE difference when comparing in-distribution and out-of-distribution model performance. We argue that developing and benchmarking data-driven models should explicitly account for modality-specific data shift characteristics.<\/jats:p>","DOI":"10.3233\/shti260163","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:02Z","timestamp":1779400622000},"source":"Crossref","is-referenced-by-count":0,"title":["Distribution Shift Analysis in Generalizable Modelling: Intensive Care Time-Series Data"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9454-7174","authenticated-orcid":false,"given":"Mayra","family":"Elwes","sequence":"first","affiliation":[{"name":"Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Alfitian","sequence":"additional","affiliation":[{"name":"Department for Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hornung","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanu","family":"Koppolu","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oya","family":"Beyan","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Kutafina","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:03Z","timestamp":1779400623000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260163","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}