{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:38:27Z","timestamp":1779403107194,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>This scoping review explores how machine learning (ML) has been applied to stroke research within the Earlier Medicine framework, which promotes proactive and personalized care through primary (preventive care), secondary (acute care), and tertiary (chronic care) prevention levels. Following PRISMA-ScR guidelines, studies were identified from PubMed and Scopus, yielding 105 eligible studies. Most studies focused on tertiary prevention, such as predicting in-hospital mortality, complications, and functional outcomes, while fewer addressed early risk prediction or acute-phase detection. Common predictors included age, NIHSS score, glucose, stroke volume, BMI, hypertension, and diabetes, reflecting reliance on routine clinical data. Traditional ML models (e.g., logistic regression, random forest, SVM) remain dominant, although Ensemble\/Hybrid and Deep Learning models have increased steadily since 2021. ML demonstrated promising predictive accuracy and clinical potential, though challenges remain in data heterogeneity, model transparency, and external validation.<\/jats:p>","DOI":"10.3233\/shti260177","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:21Z","timestamp":1779400641000},"source":"Crossref","is-referenced-by-count":0,"title":["Machine Learning Applications Within the Earlier Medicine Framework for Stroke: A Scoping Review"],"prefix":"10.3233","author":[{"given":"Ika Agustin Atika","family":"Putri","sequence":"first","affiliation":[{"name":"Department of Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-6267","authenticated-orcid":false,"given":"Annisa Ristya","family":"Rahmanti","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guardian Yoki","family":"Sanjaya","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanifah","family":"Wulandari","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfan","family":"Lazuardi","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-2558","authenticated-orcid":false,"given":"Huan X.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"London Digital Twin Research Center, Middlesex University, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:21Z","timestamp":1779400641000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260177","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}