{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T23:05:58Z","timestamp":1779404758532,"version":"3.53.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686615","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:p>The EHDS Regulation establishes patient opt-out rights for data use, yet current implementations face fragmented registries and limited tamper-proof mechanisms. In this context, opt-out refers to a patient\u2019s proactive right to object to the reuse of their health data for purposes beyond direct clinical care. We propose a distributed ledger technology (DLT)-based architecture to enhance opt-out management. Using design research and regulatory analysis of EHDS and TEHDAS, we developed a proof-of-concept leveraging permissioned DLT, smart contracts, and decentralised identifiers for an immutable registry. This architecture aligns with EHDS requirements for tamper-evident audit trails and cross-border verification. This work bridges regulatory mandates with patient-centric governance across the EU.<\/jats:p>","DOI":"10.3233\/shti260479","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:06:13Z","timestamp":1779401173000},"source":"Crossref","is-referenced-by-count":0,"title":["Leveraging Distributed Ledger Technology for Patient Opt-Out Management in the Context of the European Health Data Space"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6854-458X","authenticated-orcid":false,"given":"Syed Abrar","family":"Ahmed","sequence":"first","affiliation":[{"name":"ISCTE \u2013 Instituto Universit\u00e1rio de Lisboa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1237-6632","authenticated-orcid":false,"given":"Ricardo Correia","family":"Bezerra","sequence":"additional","affiliation":[{"name":"BIO \u2013 Global Health Platform S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3932-2770","authenticated-orcid":false,"given":"Simon","family":"Lewerenz","sequence":"additional","affiliation":[{"name":"ISCTE \u2013 Instituto Universit\u00e1rio de Lisboa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-5103","authenticated-orcid":false,"given":"Henrique","family":"Martins","sequence":"additional","affiliation":[{"name":"ISCTE \u2013 Instituto Universit\u00e1rio de Lisboa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Opening the Personal Gate between Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:06:14Z","timestamp":1779401174000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"ISBN":["9781643686615"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260479","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}