{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:54:58Z","timestamp":1781517298300,"version":"3.54.1"},"reference-count":0,"publisher":"IOS Press","isbn-type":[{"value":"9781643686677","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:p>Adolescent idiopathic scoliosis (AIS) is a multifactorial spinal deformity with poorly understood molecular mechanisms. This study investigates the role of the centrosomal protein POC5 in AIS pathogenesis using in vitro cellular systems and in vivo vertebrate models. POC5 mutations were found to disrupt centrosomal localization, impair ciliogenesis, alter cell-cycle progression, and reduce osteogenic differentiation. Functional analyses in zebrafish and mouse models revealed spinal deformities, retinal abnormalities, and multisystem defects consistent with ciliopathy-related phenotypes. These findings support a model in which POC5-dependent dysfunction contributes to AIS through impaired mechano-transduction and altered skeletal development.<\/jats:p>","DOI":"10.3233\/shti260738","type":"book-chapter","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:28:12Z","timestamp":1781515692000},"source":"Crossref","is-referenced-by-count":0,"title":["Ciliary and Osteogenic Defects as Central Drivers of AIS in POC5 Mutation Models"],"prefix":"10.3233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2622-3291","authenticated-orcid":false,"given":"Pardis","family":"Behzadi","sequence":"first","affiliation":[{"name":"Research Center Azrieli, CHU Sainte-Justine, Universit\u00e9 de Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7542-6976","authenticated-orcid":false,"given":"Amani","family":"Hassan","sequence":"additional","affiliation":[{"name":"Divisions of Plastic Surgery and Surgical and Interventional Sciences, Department of Surgery, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-4077","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Research Center Azrieli, CHU Sainte-Justine, Universit\u00e9 de Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-3547","authenticated-orcid":false,"given":"Kessen","family":"Patten","sequence":"additional","affiliation":[{"name":"Institut national de la recherche scientifique (IRNS) Laval, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-2816","authenticated-orcid":false,"given":"Stefan","family":"Parent","sequence":"additional","affiliation":[{"name":"Research Center Azrieli, CHU Sainte-Justine, Universit\u00e9 de Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-672X","authenticated-orcid":false,"given":"Florina","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Research Center Azrieli, CHU Sainte-Justine, Universit\u00e9 de Montr\u00e9al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Studies in Health Technology and Informatics","Research into Spinal Deformities 12"],"original-title":[],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/SHTI260738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:28:12Z","timestamp":1781515692000},"score":1,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/SHTI260738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"ISBN":["9781643686677"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/shti260738","relation":{},"ISSN":["0926-9630","1879-8365"],"issn-type":[{"value":"0926-9630","type":"print"},{"value":"1879-8365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]}}}