{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:31:58Z","timestamp":1777890718493,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:p>BACKGROUND: The false positive rate of the PPI test for the diagnosis of typical symptoms of gastroesophageal reflux disease (GERD) is extremely high. OBJECTIVE: This study aims to investigate the effect of the pepsin test on GERD and laparoscopy-assisted anti-reflux surgery for GERD. METHODS: A total of 30 GERD patients were enrolled into this study, and the pre-diagnosis of GERD was determined by symptom evaluation, impedance-pH examination, gastroscopy and pepsin test. All patients underwent surgery. RESULTS: Among the 30 GERD patients, 18 patients were male and 12 were female, and their average age was 58.2 + 12.6\u00a0years old. The patients were treated with laparoscopic fundoplication and hiatus hernia repair after preoperative assessment. A total of 28 patients were followed up, one patient developed recurrent symptoms, and one patient developed postoperative dysphagia and received non-operative treatment. Furthermore, the symptom scores were significantly lower at postoperative pepsin detection when compared to the scores before the operation (pepsin: preoperative: 148.8 \u00b1 82.6, postoperative: 30.7 \u00b1 24.6; t= 4.848, P= 0.000). CONCLUSIONS: Laparoscopic fundoplication and hiatus hernia repair may effectively control the symptoms of GERD. Furthermore, the detection of pepsin is non-invasive and easy to operate.<\/jats:p>","DOI":"10.3233\/thc-192090","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T15:53:58Z","timestamp":1595951638000},"page":"91-97","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy evaluation of pepsin in laparoscopic antireflux surgery for gastroesophageal reflux disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Xiang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian-Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroesophageal Reflux Disease, PLA Rocket Force General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroesophageal Reflux Disease, PLA Rocket Force General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Gao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing, China"},{"name":"Department of Gastroesophageal Reflux Disease, PLA Rocket Force General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/THC-192090_ref1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","article-title":"Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"63","author":"El-Serag","year":"2014","journal-title":"Gut."},{"key":"10.3233\/THC-192090_ref2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/MCG.0000000000000933","article-title":"The Role of Gastroesophageal Reflux in Provoking High Blood Pressure Episodes in Patients With Hypertension","volume":"52","author":"Li","year":"2018","journal-title":"J Clin Gastroenterol."},{"key":"10.3233\/THC-192090_ref3","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/nmo.12611","article-title":"Pathophysiology of gastroesophageal reflux disease: new understanding in a new era","volume":"27","author":"Herregods","year":"2015","journal-title":"Neurogastroenterol Motil."},{"key":"10.3233\/THC-192090_ref4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/gutjnl-2014-307049","article-title":"Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease","volume":"64","author":"Hayat","year":"2015","journal-title":"Gut."},{"key":"10.3233\/THC-192090_ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000143795","article-title":"Pepsin detection in the sputum\/saliva for the diagnosis of gastroesophageal reflux disease in patients with clinically suspected atypical gastroesophageal reflux disease symptoms","volume":"77","author":"Kim","year":"2008","journal-title":"Digestion."},{"key":"10.3233\/THC-192090_ref6","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.otohns.2010.08.018","article-title":"Correlation of pepsin-measured laryngopharyngeal reflux disease with symptoms and signs","volume":"143","author":"Wang","year":"2010","journal-title":"Otolaryngol Head Neck Surg."},{"key":"10.3233\/THC-192090_ref7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12876-017-0667-9","article-title":"The diagnostic value of pepsin detection in saliva for gastro-esophageal reflux disease: a preliminary study from China","volume":"17","author":"Du","year":"2017","journal-title":"BMC Gastroenterol."},{"key":"10.3233\/THC-192090_ref8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1089\/lap.2017.0360","article-title":"Role of Pepsin and Oropharyngeal pH-Monitoring to Assess the Postoperative Outcome of Patients with Laryngopharyngeal Reflux: Results of a Pilot Trial","volume":"27","author":"Weitzendorfer","year":"2017","journal-title":"J Laparoendosc Adv Surg Tech A."},{"key":"10.3233\/THC-192090_ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/lap.2016.0496","article-title":"Paraesophageal Hernia Repair: Techniques for Success","volume":"27","author":"Cohn","year":"2017","journal-title":"J Laparoendosc Adv Surg Tech A."},{"key":"10.3233\/THC-192090_ref10","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1007\/s00268-017-4040-5","article-title":"Paraesophageal Hernia and Reflux Prevention: Is One Fundoplication Better than the Other","volume":"41","author":"Andolfi","year":"2017","journal-title":"World J Surg."},{"key":"10.3233\/THC-192090_ref11","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.cgh.2012.06.030","article-title":"Limited ability of the proton-pump inhibitor test to identify patients with gastroesophageal reflux disease","volume":"10","author":"Bytzer","year":"2012","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.3233\/THC-192090_ref12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.amjmed.2010.01.007","article-title":"The diagnosis of gastroesophageal reflux disease","volume":"123","author":"Lacy","year":"2010","journal-title":"Am J Med."},{"key":"10.3233\/THC-192090_ref13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4291\/wjgp.v7.i1.72","article-title":"Esophageal testing: What we have so far","volume":"7","author":"de Bortoli","year":"2016","journal-title":"World J Gastrointest Pathophysiol."},{"key":"10.3233\/THC-192090_ref14","first-page":"1181","article-title":"Comparison of barium radiology with esophageal pH monitoring in the diagnosis of gastroesophageal reflux disease","volume":"91","author":"Johnston","year":"1996","journal-title":"Am J Gastroenterol."},{"key":"10.3233\/THC-192090_ref15","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ajg.2013.69","article-title":"High economic burden of caring for patients with suspected extraesophageal reflux","volume":"108","author":"Francis","year":"2013","journal-title":"Am J Gastroenterol."},{"key":"10.3233\/THC-192090_ref16","first-page":"535","article-title":"Abilities of Oropharyngeal pH Tests and Salivary Pepsin Analysis to Discriminate Between Asymptomatic Volunteers and Subjects With Symptoms of Laryngeal IrritationClin","volume":"14","author":"Yadlapati","year":"2016","journal-title":"Gastroenterol Hepatol."},{"key":"10.3233\/THC-192090_ref17","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/S1590-8658(13)60187-5","article-title":"Use of a Non-Invasive Pepsin Diagnostic Test to Detect GERD: Correlation With MII-pH Evaluation in a Series of Suspected NERD Patients","volume":"45","author":"De Bortoli","year":"2013","journal-title":"A Pilot Study. Digest Liver Dis."},{"key":"10.3233\/THC-192090_ref18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/nyas.12237","article-title":"Laryngopharyngeal reflux and GERD","volume":"1300","author":"Johnston","year":"2013","journal-title":"Ann N Y Acad Sci."}],"container-title":["Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/THC-192090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:44:16Z","timestamp":1777614256000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/THC-192090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":18,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/thc-192090","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]}}}