{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:12:13Z","timestamp":1788199933853,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:p>BACKGROUND: To date only scanty data exist regarding the effect of failed debridement, antibiotics, irrigation and retention of the prostheses (DAIR) and negative pressure wound therapy (NPWT) on the outcome of a subsequent exchange arthroplasty. OBJECTIVE: The objective of this study was to determine the success rate of a two- or multi-stage procedure after initial failed DAIR\/NPWT in patients with an acute periprosthetic joint infection (PJI) and to evaluate the influence of possible risk factors for treatment failure. METHODS: Nineteen consecutive patients with a persisting PJI and ongoing NPWT after treatment of an acute PJI with DAIR of the hip or knee joint from October 2010 to June 2017 were included. All patients were treated according to a structured treatment algorithm after referral to our hospital. The endpoint was a successful reimplantation with absence of signs of infection two years after replantation (\u201creplantation group\u201d) or treatment failure (\u201ctreatment failure group\u201d) in terms of a permanent girdlestone arthroplasty, fistula, amputation or death. A risk factor analysis was performed between the two groups. RESULTS: Explantation was performed in 15 cases, amputation in one case, and DAIR\/establishment of a fistula in three cases. The treatment success rate after reimplantation in terms of \u201cdefinitively free of infection\u201d two years after surgery according to Laffer was 36.85% (seven out of 19 patients). Statistical analysis revealed the number of surgeries until wound consolidation (p= 0.007), number of detected bacterial strains (p= 0.041), a polymicrobial PJI (p= 0.041) and detection of a difficult-to-treat organism (p= 0.005) as factors associated with treatment failure. After failed DAIR\/NPWT we could detect a significant higher number of different bacterial strains (p= 0.001). CONCLUSIONS: The treatment success rate after failed DAIR and NPWT with 36% is low and associated with a high treatment failure rate (permanent girdlestone arthroplasty, fistula or amputation, death). Thus, the definition of risk factors is crucial. We found that the number of revisions until wound consolidation, a polymicrobial PJI and detection of a difficult-to-treat organisms were risk factors for treatment failure. Furthermore, after failed DAIR\/NPWT we could detect a significant higher number of different bacterial strains, with a possible adverse effect on a consecutive exchange.<\/jats:p>","DOI":"10.3233\/thc-192095","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T15:28:09Z","timestamp":1589902089000},"page":"721-731","source":"Crossref","is-referenced-by-count":7,"title":["The use of negative pressure wound therapy increases failure rate in debridement and implant retention for acute prosthetic joint infection"],"prefix":"10.1177","volume":"28","author":[{"given":"Frank Sebastian","family":"Fr\u00f6schen","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Gottfried","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Martin","family":"Randau","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Gravius","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Gravius","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Bonn, Germany"},{"name":"Orthopaedic and Trauma Surgery Centre, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar Thorben Rembert","family":"Hischebeth","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/THC-192095_ref1","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1007\/s00264-013-1995-1","article-title":"Evaluation of an interdisciplinary therapy algorithm in patients with prosthetic joint infections","volume":"37","author":"Wimmer","year":"2013","journal-title":"Int Orthop."},{"key":"10.3233\/THC-192095_ref2","doi-asserted-by":"crossref","unstructured":"Argenson JN, Arndt M, Babis G, Battenberg A, Budhiparama N, Catani F, et al. 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