{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:53:10Z","timestamp":1780455190476,"version":"3.54.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n                    <jats:p>Post-traumatic stress disorder (PTSD) is a chronic mental disorder caused by mental or psychological trauma after sudden events of a catastrophic or threatening nature. Synaptic plasticity is the core mechanism of PTSD and the main point of treatment of this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Male Sprague Dawley rats were randomly divided into blank control (Ctrl), SPS (single-prolonged stress) model, SPS&amp;S model (SPS and foot electric shock), SPS+EA (SPS plus electroacupuncture), and SPS&amp;S+EA groups. Tranquilize Mind and Regulate Kidney (TMRK) electroacupuncture method was performed in each rat in the SPS+EA and SPS&amp;S+EA groups, the treatment lasted for 20 minutes per day, simultaneously for 3 consecutive weeks. Behavioral evaluations, molecular tests, electron microscopy, electrophysiological testing were conducted following the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>First, electro-acupuncture can significantly improve the PTSD-like symptoms. Second, electro-acupuncture can up-regulate the long-term potentiation (LTP) in hippocampus, repair the synaptic morphology and improve BDNF levels in amygdala and hippocampus. Third, electroacupuncture can significantly up-regulate SYN, GAP43, and PSD95 protein levels and mRNA expression in amygdala and hippocampus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The effect of TMRK electro-acupuncture method on the regression of fear memory of PTSD rats may be through its repair of synaptic plasticity in amygdala and hippocampus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/thc-199038","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T15:01:49Z","timestamp":1556636509000},"page":"425-443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Study on the mechanism of TMRK electroacupuncture in repairing synaptic plasticity in amygdala and hippocampus to relieve fear memory in PTSD rats"],"prefix":"10.1177","volume":"27","author":[{"given":"Mi","family":"Li","sequence":"first","affiliation":[{"name":"Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"},{"name":"Chinese Medicine College, Hainan Medical University, Haikou, Hainan 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"bibr1-THC-199038","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.07.004"},{"key":"bibr2-THC-199038","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.09.004"},{"key":"bibr3-THC-199038","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01064-4"},{"issue":"10","key":"bibr4-THC-199038","first-page":"1088","volume":"96","author":"Ipser J","year":"2006","journal-title":"S Afr Med J."},{"key":"bibr5-THC-199038","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.01.031"},{"key":"bibr6-THC-199038","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00387"},{"issue":"9","key":"bibr7-THC-199038","first-page":"562","volume":"43","author":"Zhao YK","year":"2018","journal-title":"Zhen Ci Yan Jiu."},{"key":"bibr8-THC-199038","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e31803044f8"},{"key":"bibr9-THC-199038","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.08013"},{"key":"bibr10-THC-199038","first-page":"1","volume":"2012","author":"Wang Y","year":"2012","journal-title":"Evid Based Complement Alternat Med."},{"issue":"9","key":"bibr11-THC-199038","first-page":"1505","volume":"25","author":"Zhang H","year":"2010","journal-title":"Wenchuan Earthquake. 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