{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:37:09Z","timestamp":1777891029628,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:p>BACKGROUND: Thyroid metabolism involves iodine, which allows us to use radioactive iodine for diagnostic and therapy purposes. The efficiency of radioiodine therapy depends on several parameters; the ability of thyroid tissue to uptake radioactive iodine is one of them. OBJECTIVE: The objective of this work is to quantify the radioactive iodine uptake on thyroid tissue. METHODS: In this work, we developed a method to quantify the in vivo uptake of iodine-131 on sections of thyroid glands removed by thyroidectomies. We performed an analysis of histological sections of the thyroid tissue by beta imaging. We had the opportunity to quantify the fixed radioactivity and to analyze its distribution in the thyroid gland, thanks to the good spatial resolution available with the type of detector used. RESULTS: The results gave a high image resolution showing the heterogeneity of iodine-131 fixation by the thyroid tissue. We were able to quantify the tissue radioactivity in mega Becquerel (MBq) per volume unit. CONCLUSION: This work has shown that the direct quantification of the thyroid tissue uptake is possible using the beta imaging system.<\/jats:p>","DOI":"10.3233\/thc-202401","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T16:49:11Z","timestamp":1606841351000},"page":"431-443","source":"Crossref","is-referenced-by-count":0,"title":["Tissue quantification of radioiodine thyroid uptake in humans by an isotopic imaging technique on slides"],"prefix":"10.1177","volume":"29","author":[{"given":"Achwak","family":"Cherif","sequence":"first","affiliation":[{"name":"Laboratory of Metabolic Biophysics and Environmental and Applied Toxicology, LR12ES02, Faculty of Medicine, Sousse University, Sousse, Tunisia"},{"name":"University of Tunis El Manar, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Nouira","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolic Biophysics and Environmental and Applied Toxicology, LR12ES02, Faculty of Medicine, Sousse University, Sousse, Tunisia"},{"name":"Nuclear Medicine Department, Sahloul Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Barthe","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics, BIOTIS \u2013 INSERM U1026, University of Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhouane","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Sahloul Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Kermani","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, FarhatHached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihed","family":"Abdessayed","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology and Cytology, FarhatHached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad","family":"Saguem","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolic Biophysics and Environmental and Applied Toxicology, LR12ES02, Faculty of Medicine, Sousse University, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Basse-Cathalinat","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics, BIOTIS \u2013 INSERM U1026, University of Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Guezguez","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Sahloul Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/THC-202401_ref1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1089\/thy.1997.7.177","article-title":"Iodine metabolism and thyroid physiology: current concepts","volume":"7","author":"Cavalieri","year":"1997","journal-title":"Thyroid"},{"key":"10.3233\/THC-202401_ref2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/162495a0","article-title":"Auroradiography of the thyroid gland","volume":"162","author":"Bourne","year":"1948","journal-title":"Nature"},{"key":"10.3233\/THC-202401_ref3","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1088\/0031-9155\/52\/16\/019","article-title":"Digital autoradiography using room temperature CCD and CMOS imaging technology","volume":"52","author":"Cabello","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.3233\/THC-202401_ref4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/BF00175056","article-title":"An autoradiography study of postoperatively labelled thyroid tissue and iodine storage","volume":"18","author":"Ahuja","year":"1991","journal-title":"Eur J Nucl Med"},{"key":"10.3233\/THC-202401_ref5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10967-013-2535-6","article-title":"Digital autoradiography (DA) in quantification of trace level beta emitters on concrete","volume":"298","author":"Leskinen","year":"2013","journal-title":"J Radioanal Nucl Chem"},{"key":"10.3233\/THC-202401_ref6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0168-9002(00)01265-1","article-title":"BETAview autoradiography system: laboratory tests and biological experiments","volume":"461","author":"Montesi","year":"2001","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.3233\/THC-202401_ref7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.mednuc.2007.03.004","article-title":"L\u2019imagerie b\u00eata haute r\u00e9solution","volume":"31","author":"Barthe","year":"2007","journal-title":"M\u00e9decine Nucl\u00e9aire \u2013 Imagerie Fonctionnelle et M\u00e9tabolique"},{"key":"10.3233\/THC-202401_ref8","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/002215549804601006","article-title":"A new quantitative film autoradiographic method of quantifying mRNA transcripts","volume":"46","author":"Palfi","year":"1998","journal-title":"The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society"},{"key":"10.3233\/THC-202401_ref9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1385-299X(01)00082-4","article-title":"Methods for quantification of in situ hybridization signals obtained by film","volume":"8","author":"Vizi","year":"2001","journal-title":"Brain Res Brain Res Protoc"},{"key":"10.3233\/THC-202401_ref10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1210\/jcem-9-4-342","article-title":"The use of tracer doses of radioactive iodine, I131, in the study of normal and disordered thyroid function in man","volume":"9","author":"Sidney","year":"1949","journal-title":"The Journal of Clinical Endocrinology"},{"key":"10.3233\/THC-202401_ref11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3109\/00016925309136732","article-title":"A study of the iodine-concentrating function of the thyroid after treatment with radioactive iodine","volume":"39","author":"Larsson","year":"1953","journal-title":"Acta Radiologica"},{"key":"10.3233\/THC-202401_ref12","first-page":"244","article-title":"Neck and whole-body scanning with 5-mCi dose of (123)I as diagnostic tracer in patients with well-differentiated thyroid cancer","volume":"7","author":"Gulzar","year":"2001","journal-title":"Endocrine Practice"}],"container-title":["Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/THC-202401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:52:16Z","timestamp":1777614736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/THC-202401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":12,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/thc-202401","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,17]]}}}