{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T05:18:07Z","timestamp":1737091087759,"version":"3.33.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2021,9,6]]},"abstract":"<jats:p>OBJECTIVE: This study aimed to investigate the clinical characteristics and outcomes of coronavirus disease-19 (COVID-19) long-term nucleic acid positive patients (hereinafter referred to as CLTAPs). METHODS: Patients were recruited from the Xiaogan Central Hospital between 16 January 2020 and 28 March 2020. Among the 562 cases of patients with laboratory-identified COVID-19 infection by real-time polymerase chain reaction (qtPCR), 19 cases of COVID-19 patients with more than 41 days from the first to the last time of nucleic acid test were selected as the study group, and 76 cases of age- and gender-matched COVID-19 patients were selected as the control group (hereinafter referred to as C-CLTAPs). Demographic characteristics, clinical symptoms, laboratory examination and computed tomography (CT) imaging characteristics were retrospectively analyzed. RESULTS: On admission, among the 562 cases of patients with COVID-19, there were 398 cases of ordinary COVID-19 patients, 99 cases of severe COVID-19 patients and 99 cases of critical COVID-19 patients. CLTAPs had milder clinical symptoms and longer viral shedding time in comparison to C-CLTAPs. Compared to C-CLTAPs, CLTAPs had a lower infection index at admission. CLTAPs used less oxygen therapy and a higher proportion of hydroxychloroquine treatment in comparison to C-CLTAPs. In comparison to C-CLTAPs, CLTAPs showed slower pulmonary CT progression and faster pulmonary CT absorption. CONCLUSION: In this study, out of the 562 cases, we found 19 CLTAPs. The clinical differences between CLTAPs and C-CLTAPs were compared and analyzed. We hope that these finding can provide a theoretical basis for the treatment of CLTAPs.<\/jats:p>","DOI":"10.3233\/thc-212921","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T09:31:01Z","timestamp":1625650261000},"page":"849-858","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and outcomes of COVID-19 long-term nucleic acid positive patients"],"prefix":"10.1177","volume":"29","author":[{"given":"Xuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Medical College of Wuhan University of Science and Technology, Wuhan, Hubei, China"},{"name":"Medical College of Wuhan University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical College of Wuhan University of Science and Technology, Wuhan, Hubei, China"},{"name":"Medical College of Wuhan University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical College of Wuhan University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical College of Wuhan University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Yan","sequence":"additional","affiliation":[{"name":"Medical College of Wuhan University of Science and Technology, Wuhan, Hubei, China"},{"name":"Department of Internal Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/THC-212921_ref4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tim.2016.03.003","article-title":"Epidemiology, genetic recombination, and pathogenesis of coronaviruses","volume":"24","author":"Su","year":"2016","journal-title":"Trends Microbiol"},{"key":"10.3233\/THC-212921_ref7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tim.2016.03.003","article-title":"Epidemiology, genetic recombination, and pathogenesis of coronaviruses","volume":"24","author":"Su","year":"2016","journal-title":"Trends Microbiol."},{"key":"10.3233\/THC-212921_ref8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat Rev Microbiol."},{"key":"10.3233\/THC-212921_ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"10.3233\/THC-212921_ref10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet."},{"key":"10.3233\/THC-212921_ref11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat Rev Microbiol."},{"key":"10.3233\/THC-212921_ref12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.chom.2015.09.013","article-title":"MERS, SARS, and Ebola: the role of super-spreaders in infectious disease","volume":"18","author":"Wong","year":"2015","journal-title":"Cell Host Microbe."},{"key":"10.3233\/THC-212921_ref13","doi-asserted-by":"crossref","unstructured":"Lai CC, Shih TP, Ko WC, et al. 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