{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:01:25Z","timestamp":1791259285171,"version":"4.1.0"},"reference-count":83,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2022,11,12]]},"abstract":"<jats:p>BACKGROUND: Digital phenotyping has been defined as the moment-by-moment assessment of an illness state through digital means, promising objective, quantifiable data on psychiatric patients\u2019 conditions, and could potentially improve diagnosis and management of mental illness. As it is a rapidly growing field, it is to be expected that new literature is being published frequently. OBJECTIVE: We conducted this scoping review to assess the current state of literature on digital phenotyping and offer some discussion on the current trends and future direction of this area of research. METHODS: We searched four databases, PubMed, Ovid MEDLINE, PsycINFO and Web of Science, from inception to August 25th, 2021. We included studies written in English that 1) investigated or applied their findings to diagnose psychiatric disorders and 2) utilized passive sensing for management or diagnosis. Protocols were excluded. A narrative synthesis approach was used, due to the heterogeneity and variability in outcomes and outcome types reported. RESULTS: Of 10506 unique records identified, we included a total of 107 articles. The number of published studies has increased over tenfold from 2 in 2014 to 28 in 2020, illustrating the field\u2019s rapid growth. However, a significant proportion of these (49% of all studies and 87% of primary studies) were proof of concept, pilot or correlational studies examining digital phenotyping\u2019s potential. Most (62%) of the primary studies published evaluated individuals with depression (21%), BD (18%) and SZ (23%) (Appendix\u00a01). CONCLUSION: There is promise shown in certain domains of data and their clinical relevance, which have yet to be fully elucidated. A consensus has yet to be reached on the best methods of data collection and processing, and more multidisciplinary collaboration between physicians and other fields is needed to unlock the full potential of digital phenotyping and allow for statistically powerful clinical trials to prove clinical utility.<\/jats:p>","DOI":"10.3233\/thc-213648","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T12:26:06Z","timestamp":1653999966000},"page":"1331-1342","source":"Crossref","is-referenced-by-count":27,"title":["Digital phenotyping in psychiatry: A scoping review"],"prefix":"10.1177","volume":"30","author":[{"given":"Alex Z.R.","family":"Chia","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore City, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvyn W.B.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore City, Singapore"},{"name":"National Addictions Management Service, Institute of Mental Health, Singapore City, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"5","key":"10.3233\/THC-213648_ref1","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nbt.3223","article-title":"The digital phenotype","volume":"33","author":"Jain","year":"2015","journal-title":"Nature Biotechnology."},{"issue":"13","key":"10.3233\/THC-213648_ref2","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1001\/jama.2017.11295","article-title":"Digital Phenotyping: Technology for a New Science of Behavior","volume":"318","author":"Insel","year":"2017","journal-title":"Jama."},{"issue":"1","key":"10.3233\/THC-213648_ref3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41746-018-0018-4","article-title":"Digital biomarkers of cognitive function","volume":"1","author":"Dagum","year":"2018","journal-title":"NPJ Digital Medicine."},{"key":"10.3233\/THC-213648_ref4","doi-asserted-by":"publisher","DOI":"10.2196\/mhealth.2994"},{"issue":"10","key":"10.3233\/THC-213648_ref5","doi-asserted-by":"publisher","first-page":"e13479","DOI":"10.2196\/13479","article-title":"Development of an Ambulatory Biofeedback App to Enhance Emotional Awareness in Patients with Borderline Personality Disorder: Multicycle Usability Testing Study","volume":"7","author":"Derks","year":"2019","journal-title":"JMIR Mhealth Uhealth."},{"key":"10.3233\/THC-213648_ref6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jad.2017.12.059","article-title":"Disease management apps and technical assistance systems for bipolar disorder: Investigating the patients\u2019 point of view","volume":"229","author":"Daus","year":"2018","journal-title":"J Affect Disord."},{"key":"10.3233\/THC-213648_ref8","doi-asserted-by":"crossref","unstructured":"Connaghan K, Green J, Paganoni S, Chan J, Weber H, Collins E, et al. 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