{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:00:38Z","timestamp":1781881238942,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2021,3,25]]},"abstract":"<jats:p>OBJECTIVE: We waimed to investigate whether H2S can relieve the myocardial fibrosis caused by doxorubicin through Keap1-Nrf2. METHODS: Sprague-Dawley (SD) rats were randomly divided into four groups: normal control group (Control); DOX model group (DOX); H2S intervention model group (DOX+H2S); H2S control group (H2S). DOX and DOX+H2S group were injected with doxorubicin (3.0 mg\/kg\/time) intraperitoneally. Both of the Control group and H2S groups were given normal saline in equal volume, 2 weeks later, DOX+H2S and H2S group were controlled with NaHS (56 \u03bcmol\/kg\/d) through the abdominal cavity, while the Control and DOX group were injected with normal saline of the same dosage intraperitoneally. RESULTS: Myocardial injury and myocardial cell apoptosis were significantly increased, the H2S content in myocardial tissue was remarkably down-regulated, the expression levels of MDA, Keap1, caspase-3, caspase-9, TNF-\u03b1, IL1\u03b2, MMPs and TIMP-1 in rat myocardial tissue was significantly up-regulated (P&lt; 0.05), and the expression levels of GSH, NQO1, Bcl-2 were down-regulated compared with those of control group. The above results can be reversed by the DOX+H2S group. There is no statistically significant difference between the Control group and the H2S control group. CONCLUSIONS: These results suggest that H2S can improve DOX-induced myocardial fibrosis in rats, and the keap1\/Nrf2 signaling pathway, oxidative stress, inflammation, and apoptosis may be involved in the mechanism.<\/jats:p>","DOI":"10.3233\/thc-218020","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T13:13:05Z","timestamp":1614690785000},"page":"195-209","source":"Crossref","is-referenced-by-count":24,"title":["H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2"],"prefix":"10.1177","volume":"29","author":[{"given":"Yaling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"},{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakur Prakash","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"},{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"},{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangui","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maojun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of University of South 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