{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:59:27Z","timestamp":1791615567534,"version":"4.3.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2023,5,12]]},"abstract":"<jats:p>BACKGROUND: Aneurysms are associated with a mortality rate of 81% or more in cases of rupture. Intraluminal thrombus (ILT) is a common complication of aneurysms, it can greatly increase the risk of rupture. Especially for some of the more complex aneurysms, physicians need to consider the risk of thrombosis or progression and precisely formulate a treatment plan. Therefore, it is particularly important to assess the level of thrombosis risk through haemodynamics. OBJECTIVE: To analyse the haemodynamic indices and compare the thrombosis risk in a double false lumen abdominal aortic dissection aneurysm using computational fluid dynamics (CFD). METHODS: Computer tomography angiography (CTA) imaging data were collected from a patient with a double false lumen abdominal aortic dissection aneurysm, and three different lesion morphology aneurysm models were established, double false lumen abdominal aortic dissection aneurysm, single false lumen abdominal aortic dissection aneurysm and saccular abdominal aortic aneurysm, in order to analyse the flow velocity, time-averaged shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT) of blood flow, and endothelial cell activation potential (ECAP). RESULTS: All three aneurysms were in a low-flow state within the body, and the low-flow velocity flow in the proximal vessel wall extended to the right common iliac artery; the vortex intensity was more intense in the abdominal aortic dissection aneurysm than in the saccular abdominal aortic aneurysm. The risk area for thrombosis was concentrated in the expansion part of the aneurysm and the false lumen. The RRT and ECAP maxima of the double false lumen abdominal aortic dissection aneurysm were much greater than those of the single false lumen dissection aneurysm and saccular aortic aneurysm. CONCLUSION: Low-velocity blood flow, high OSI, low TAWSS, high RRT, and high ECAP regions correlate with the risk of thrombosis. The double false lumen type of abdominal aortic dissection aneurysm had some specificity in this case. The risk of thrombosis in the patient was extremely high, and the largest risk zone was within the smaller false lumen, which could be because the smaller false lumen was connected to the true lumen by only one breach. The results of the study provide some guidance in the early screening and development of treatment plans.<\/jats:p>","DOI":"10.3233\/thc-220481","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T11:13:54Z","timestamp":1669115634000},"page":"1003-1015","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of thrombosis risk in an abdominal aortic dissection aneurysm with a double false lumen using computational fluid dynamic simulation method"],"prefix":"10.1177","volume":"31","author":[{"given":"Hongbing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[{"name":"Technical Department of Interpol Corps of the Chongqing Public Bureau, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"5","key":"10.3233\/THC-220481_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12968\/hmed.2019.0351","article-title":"Abdominal aortic aneurysms","volume":"82","author":"Ahmed","year":"2021","journal-title":"British Journal of Hospital Medicine (London, England: 2005)"},{"issue":"3","key":"10.3233\/THC-220481_ref2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/2048872620976508","article-title":"New clues for optimal diagnosis and treatment of an old foe: the acute aortic syndrome","volume":"9","author":"Bonaca","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care."},{"issue":"22","key":"10.3233\/THC-220481_ref3","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1001\/jama.2019.17021","article-title":"Primary Care Screening for Abdominal Aortic Aneurysm: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force","volume":"322","author":"Guirguis-Blake","year":"2019","journal-title":"JAMA."},{"key":"10.3233\/THC-220481_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2821"},{"issue":"4","key":"10.3233\/THC-220481_ref5","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/CIRCULATIONAHA.109.880724","article-title":"Site specificity of aneurysmal disease","volume":"121","author":"Norman","year":"2010","journal-title":"Circulation."},{"issue":"6","key":"10.3233\/THC-220481_ref6","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1016\/j.jvs.2016.05.101","article-title":"Screening for abdominal aortic aneurysm in asymptomatic adults","volume":"64","author":"Ali","year":"2016","journal-title":"Journal of Vascular Surgery."},{"issue":"6","key":"10.3233\/THC-220481_ref7","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1016\/j.jvs.2019.03.057","article-title":"Systematic review and meta-analysis of the association between intraluminal thrombus volume and abdominal aortic aneurysm rupture","volume":"70","author":"Singh","year":"2019","journal-title":"Journal of Vascular Surgery."},{"issue":"11","key":"10.3233\/THC-220481_ref8","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1161\/atvbaha.114.304488","article-title":"Thrombosis: a major contributor to global disease burden","volume":"34","author":"Raskob","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology."},{"issue":"6s","key":"10.3233\/THC-220481_ref9","doi-asserted-by":"publisher","first-page":"30s","DOI":"10.1016\/j.jvs.2017.12.030","article-title":"Tissue factor levels and the fibrinolytic system in thin and thick intraluminal thrombus and underlying walls of abdominal aortic aneurysms","volume":"68","author":"Siennicka","year":"2018","journal-title":"Journal of Vascular Surgery."},{"key":"10.3233\/THC-220481_ref10","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070942"},{"issue":"9","key":"10.3233\/THC-220481_ref11","doi-asserted-by":"publisher","first-page":"4263","DOI":"10.1002\/mp.13658","article-title":"Role of intraluminal thrombus in abdominal aortic aneurysm ruptures: A hemodynamic point of view","volume":"46","author":"Qiu","year":"2019","journal-title":"Med Phys."},{"issue":"3","key":"10.3233\/THC-220481_ref12","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s10237-019-01269-4","article-title":"Analysis of morphological and hemodynamical indexes in abdominal aortic aneurysms as preliminary indicators of intraluminal thrombus deposition","volume":"19","author":"Colciago","year":"2020","journal-title":"Biomechanics and Modeling in Mechanobiology."},{"issue":"6","key":"10.3233\/THC-220481_ref13","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.29252\/jafm.12.06.29769","article-title":"Pulsatile Flow Investigation in Development of Thoracic Aortic Aneurysm: An In-Vitro Validated Fluid Structure Interaction Analysis","volume":"12","author":"Ong","year":"2019","journal-title":"Journal of Applied Fluid Mechanics."},{"key":"10.3233\/THC-220481_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3587"},{"key":"10.3233\/THC-220481_ref15","doi-asserted-by":"publisher","first-page":"106508","DOI":"10.1016\/j.cmpb.2021.106508","article-title":"Hemodynamic simulation of abdominal aortic aneurysm on idealised models: Investigation of stress parameters during disease progression","volume":"213","author":"Philip","year":"2022","journal-title":"Computer Methods and Programs in Biomedicine."},{"issue":"3","key":"10.3233\/THC-220481_ref16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00234-018-2135-9","article-title":"Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location","volume":"61","author":"Detmer","year":"2019","journal-title":"Neuroradiology."},{"issue":"5","key":"10.3233\/THC-220481_ref17","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1115\/1.1992521","article-title":"3-D numerical simulation of blood flow through models of the human aorta","volume":"127","author":"Morris","year":"2005","journal-title":"Journal of Biomechanical Engineering."},{"issue":"11","key":"10.3233\/THC-220481_ref18","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s11517-008-0361-8","article-title":"A computational study on the biomechanical factors related to stent-graft models in the thoracic aorta","volume":"46","author":"Lam","year":"2008","journal-title":"Med Biol Eng Comput."},{"issue":"2","key":"10.3233\/THC-220481_ref19","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3233\/XST-17256","article-title":"Pulsatile hemodynamics in patient-specific thoracic aortic dissection models constructed from computed tomography angiography","volume":"25","author":"Long Ko","year":"2017","journal-title":"J Xray Sci Technol."},{"issue":"1","key":"10.3233\/THC-220481_ref20","doi-asserted-by":"publisher","first-page":"8600","DOI":"10.1038\/s41598-019-45097-z","article-title":"Patient-specific Computational Hemodynamic Analysis for Interrupted Aortic Arch in an Adult: Implications for Aortic Dissection Initiation","volume":"9","author":"Peng","year":"2019","journal-title":"Scientific Reports."},{"issue":"3","key":"10.3233\/THC-220481_ref21","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.jvs.2015.04.421","article-title":"Examination of near-wall hemodynamic parameters in the renal bridging stent of various stent graft configurations for repairing visceral branched aortic aneurysms","volume":"64","author":"Suess","year":"2016","journal-title":"Journal of Vascular Surgery."},{"issue":"16","key":"10.3233\/THC-220481_ref22","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1080\/10255842.2018.1522531","article-title":"Hemodynamic investigation of a patient-specific abdominal aortic aneurysm with iliac artery tortuosity","volume":"21","author":"Qiu","year":"2018","journal-title":"Computer Methods in Biomechanics and Biomedical Engineering."},{"issue":"4","key":"10.3233\/THC-220481_ref23","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s13239-021-00532-z","article-title":"Influence of Distal Re-entry Tears on False Lumen Thrombosis After Thoracic Endovascular Aortic Repair in Type B Aortic Dissection Patients: A Computational Fluid Dynamics Simulation","volume":"12","author":"Li","year":"2021","journal-title":"Cardiovasc Eng Technol."},{"issue":"3","key":"10.3233\/THC-220481_ref24","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ejvs.2017.06.012","article-title":"Elevated Wall Shear Stress in Aortic Type B Dissection May Relate to Retrograde Aortic Type A Dissection: A Computational Fluid Dynamics Pilot Study","volume":"54","author":"Osswald","year":"2017","journal-title":"Eur J Vasc Endovasc Surg."},{"key":"10.3233\/THC-220481_ref25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ijcard.2019.01.092","article-title":"Hemodynamic variables in aneurysms are associated with thrombotic risk in children with Kawasaki disease","volume":"281","author":"Grande Gutierrez","year":"2019","journal-title":"International Journal of Cardiology."},{"key":"10.3233\/THC-220481_ref26","doi-asserted-by":"publisher","first-page":"8507273","DOI":"10.1155\/2020\/8507273","article-title":"Hemodynamic-Based Evaluation on Thrombosis Risk of Fusiform Coronary Artery Aneurysms Using Computational Fluid Dynamic Simulation Method","volume":"2020","author":"Wang","year":"2020","journal-title":"Complexity."},{"key":"10.3233\/THC-220481_ref27","doi-asserted-by":"publisher","first-page":"855791","DOI":"10.3389\/fbioe.2022.855791","article-title":"Medical Image-Based Computational Fluid Dynamics and Fluid-Structure Interaction Analysis in Vascular Diseases","volume":"10","author":"He","year":"2022","journal-title":"Frontiers in Bioengineering and Biotechnology."},{"key":"10.3233\/THC-220481_ref28","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.avsg.2019.04.032","article-title":"Computational Fluid Dynamics Modeling of Hemodynamic Parameters in the Human Diseased Aorta: A Systematic Review","volume":"63","author":"Ong","year":"2020","journal-title":"Annals of Vascular Surgery."},{"issue":"1","key":"10.3233\/THC-220481_ref29","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1161\/strokeaha.110.592923","article-title":"Hemodynamic-morphologic discriminants for intracranial aneurysm rupture","volume":"42","author":"Xiang","year":"2011","journal-title":"Stroke."},{"key":"10.3233\/THC-220481_ref30","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2022-001606"}],"container-title":["Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/THC-220481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:55:40Z","timestamp":1777614940000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/THC-220481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":30,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/thc-220481","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,12]]}}}