{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:39:24Z","timestamp":1777891164832,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:p>BACKGROUND: It is estimated that 1.95% and 5.55% of adults in China suffer from subclinical thyroid diseases, which is difficult to diagnose and treat. OBJECTIVE: This study aimed to explore the development and prognosis of subclinical thyroid diseases to provide a reference from our single center experience. METHODS: A total of 240 cases from April 2019 to August 2021 in the laboratory information system database of Huanghua Development Boai Hospital were retrospectively analyzed. Binary logistic regression was conducted to analyze odds ratio (OR) of subclinical thyroid disease types returning to a normal state. RESULTS: Among the patients hypothyroidism Ia and hyperthyroidism Ia were the most common type with conversion to the normal state (P&lt; 0.001). TSH level of patients with conversion to a normal state was significantly lower than that of those who developed to abnormal disease (P= 0.015). The OR values of hyperthyroidism Ia and hypothyroidism Ia that returned to a normal state compared with hyperthyroidism Ib were 2.659 (1.159 \u223c 6.096, P= 0.021) and 3.138 (1.1.278 \u223c 7.709, P= 0.013), respectively. The OR value of hypothyroidism Ib that returned to normal compared with hyperthyroidism Ib was 0.629 (0.131 \u223c 3.010, P= 0.561). Thyroid hormone levels, age, and gender at first diagnosis were not impact factor for prognosis of subclincal thyroid disease (P&gt; 0.05). CONCLUSION: Cases with grade hypothyroidism Ia and hyperthyroidism Ia are more likely to revert to normal state than other subclinical thyroid diseases. TSH reference range should be explored for diagnosis and treatment.<\/jats:p>","DOI":"10.3233\/thc-220562","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T13:13:56Z","timestamp":1682082836000},"page":"1715-1722","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary observation of thyroid function changes in subclinical thyroid diseases"],"prefix":"10.1177","volume":"31","author":[{"given":"Hua-Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Huanghua Boai Hospital, Cangzhou, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Huanghua Boai Hospital, Cangzhou, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Huanghua Boai Hospital, Cangzhou, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Huanghua Boai Hospital, Cangzhou, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cangzhou Medical College, Cangzhou, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cangzhou Hospital of Integrated TCM-WM, Cangzhou, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Huanghua Boai Hospital, Cangzhou, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/THC-220562_ref1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/qjmed\/hcu216","article-title":"Iodine nutrition and thyroid diseases in Chengdu, China: an epidemiological study","volume":"108","author":"Yan","year":"2015","journal-title":"QJM"},{"issue":"3","key":"10.3233\/THC-220562_ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000438750","article-title":"The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism","volume":"4","author":"Biondi","year":"2015","journal-title":"Eur Thyroid J."},{"issue":"3","key":"10.3233\/THC-220562_ref3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000438909","article-title":"Guidance in Subclinical Hyperthyroidism and Subclinical Hypothyroidism: Are We Making Progress","volume":"4","author":"Wiersinga","year":"2015","journal-title":"Eur Thyroid J."},{"issue":"2","key":"10.3233\/THC-220562_ref4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jama.2019.9052","article-title":"Subclinical Hypothyroidism: A Review","volume":"322","author":"Biondi","year":"2019","journal-title":"JAMA."},{"issue":"692","key":"10.3233\/THC-220562_ref5","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.3399\/bjgp20X708065","article-title":"Subclinical thyroid dysfunction symptoms in older adults: cross-sectional study in UK primary care","volume":"70","author":"McCahon","year":"2020","journal-title":"Br J Gen Pract."},{"issue":"1","key":"10.3233\/THC-220562_ref6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/medicina56010040","article-title":"To Treat or Not to Treat Subclinical Hypothyroidism, What Is the Evidence","volume":"56","author":"Calissendorff","year":"2020","journal-title":"Medicina (Kaunas)."},{"issue":"6","key":"10.3233\/THC-220562_ref7","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.mcna.2021.05.014","article-title":"Decision Making in Subclinical Thyroid Disease","volume":"105","author":"Evron","year":"2021","journal-title":"Med Clin North Am."},{"issue":"12","key":"10.3233\/THC-220562_ref8","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1089\/thy.2012.0205","article-title":"Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association [published correction appears in Thyroid. 2013 Feb; 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