{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:39:37Z","timestamp":1777891177953,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:p>BACKGROUND: Pregnancy luteoma is a rare hormone-dependent ovarian tumor-like lesion caused by increased androgenic activity during pregnancy. OBJECTIVE: To explore the clinical history, ultrasound manifestations, and differential diagnosis of pregnancy luteoma. METHOD: A retrospective analysis was conducted on 26 cases of pregnancy luteoma diagnosed by postoperative pathology, from 2009 to 2022. All cases were from two hospitals: Shanghai First Maternity and Infant Hospital and International Peace Maternity and Child Health Hospital. The clinical history data and ultrasound characteristics were analyzed and the relevant literature was reviewed. RESULTS: Among the 26 cases, five of them had preoperative ultrasound images. Among these five cases, three patients showed hyperechoic masses with less internal uniformity, while two demonstrated loculated anechoic zones, with clear boundary and regular morphology. Color Doppler showed no obvious internal blood flow signals, or that blood flow signals were visible within the cyst wall and hyperechoic mass. Among the cases, 16 had multiple gestations, while two visited the clinic due to sudden abdominal pain and a huge ovarian mass was found by ultrasonography. The ovarian lump was detected during routine obstetric ultrasound in three cases. The remaining were ovarian cysts found incidentally during caesarean section. Four patients presented with hairy manifestations and one patient had a deepened voice. CONCLUSION: There is no characteristic ultrasound of pregnancy luteoma, and its diagnosis is mainly based on clinical history data and laboratory tests.<\/jats:p>","DOI":"10.3233\/thc-220685","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T12:38:07Z","timestamp":1682685487000},"page":"1825-1833","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective analysis of 26 cases of pregnancy luteoma"],"prefix":"10.1177","volume":"31","author":[{"given":"Bao-Ying","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Ultrasonography, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Shanghai Key Laboratory of Maternal and Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"11","key":"10.3233\/THC-220685_ref1","first-page":"1055","article-title":"Two cases of luteoma of pregnancy in ovary","volume":"36","author":"Cai","year":"2020","journal-title":"Chinese Journal of Ultrasound Medicine."},{"key":"10.3233\/THC-220685_ref2","doi-asserted-by":"publisher","first-page":"6695117","DOI":"10.1155\/2021\/6695117","article-title":"Hirsutism caused by pregnancy luteoma in a low-resource setting: A case report and literature review","volume":"2021","author":"Mvunta","year":"2021","journal-title":"Case Rep Obstet Gynecol."},{"issue":"2","key":"10.3233\/THC-220685_ref3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/PAS.0000000000000100","article-title":"Pregnancy luteoma: A study of 20 cases on the occasion of the 50th anniversary of its description by Dr. William H. Sternberg, with an emphasis on the common presence of follicle-like spaces and their diagnostic implications","volume":"38","author":"Burandt","year":"2014","journal-title":"Am J Surg Pathol."},{"issue":"3","key":"10.3233\/THC-220685_ref4","doi-asserted-by":"publisher","first-page":"393","DOI":"10.5858\/134.3.393","article-title":"Pseudoneoplastic lesions of the female genital tract","volume":"134","author":"Medeiros","year":"2010","journal-title":"Arch Pathol Lab Med."},{"issue":"2","key":"10.3233\/THC-220685_ref5","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/00004347-199304000-00004","article-title":"Tumor-like lesions of the ovary associated with pregnancy","volume":"12","author":"Clement","year":"1993","journal-title":"Int J Gynecol Pathol."},{"issue":"2","key":"10.3233\/THC-220685_ref6","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.4158\/EP13056","article-title":"Luteoma of pregnancy associated with nearly complete virilization of genetically female twins","volume":"20","author":"Wadzinski","year":"2014","journal-title":"Endocr Pract."},{"issue":"2","key":"10.3233\/THC-220685_ref7","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.4158\/EP13056","article-title":"Luteoma of pregnancy associated with nearly complete virilization of genetically female twins","volume":"20","author":"Wadzinski","year":"2014","journal-title":"Endocr Pract."},{"issue":"10","key":"10.3233\/THC-220685_ref8","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1080\/09513590.2022.2114448","article-title":"A case of excision of ovarian torsion necrosis due to luteoma in a female who conceived a twin pregnancy through in vitro fertilization misdiagnosed with acute appendicitis","volume":"38","author":"Zhu","year":"2022","journal-title":"Gynecol Endocrinol."},{"issue":"9","key":"10.3233\/THC-220685_ref9","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.diii.2016.03.004","article-title":"Multidetector-row computed tomography (MDCT) findings of adnexal torsion: An analysis of 116 patients","volume":"97","author":"Lee","year":"2016","journal-title":"Diagn Interv Imaging."},{"issue":"4","key":"10.3233\/THC-220685_ref10","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/00006254-197804000-00016","article-title":"Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis","volume":"33","author":"Hensleigh","year":"1978","journal-title":"Obstet Gynecol Surv."},{"issue":"3","key":"10.3233\/THC-220685_ref11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/0002-9378(77)90781-5","article-title":"Virilization of mother and fetus associated with luteoma of pregnancy: A case report with endocrinologic studies","volume":"129","author":"Verkauf","year":"1977","journal-title":"Am J Obstet Gynecol."},{"issue":"12","key":"10.3233\/THC-220685_ref12","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/S0344-0338(99)80110-1","article-title":"Pregnancy luteoma with granulosa cell proliferation: An unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia","volume":"195","author":"Piana","year":"1999","journal-title":"Pathol Res Pract."},{"issue":"2","key":"10.3233\/THC-220685_ref13","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.fertnstert.2005.02.029","article-title":"Maternal and female fetal virilization caused by pregnancy luteomas","volume":"84","author":"Wang","year":"2005","journal-title":"Fertil Steril."},{"issue":"9","key":"10.3233\/THC-220685_ref14","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/OGX.0b013e3181f8c41d","article-title":"Pregnancy luteomas: Clinical presentations and management strategies","volume":"65","author":"Masarie","year":"2010","journal-title":"Obstet Gynecol Surv."},{"issue":"12","key":"10.3233\/THC-220685_ref15","first-page":"2041","article-title":"Ultrasonographic manifestations of luteoma gravidarum with ascites and elevated CA125: A case report","volume":"29","author":"Yang","year":"2019","journal-title":"Medical Imaging"},{"issue":"7","key":"10.3233\/THC-220685_ref16","first-page":"604","article-title":"Color doppler ultrasonography of pregnant luteoma: A case report","volume":"11","author":"Sha","year":"2014","journal-title":"Chinese Journal of Medical Ultrasound (Electronic Edition)."},{"issue":"12","key":"10.3233\/THC-220685_ref17","doi-asserted-by":"publisher","first-page":"877","DOI":"10.7863\/jum.2000.19.12.877","article-title":"Luteoma of pregnancy: Sonographic findings in two cases","volume":"19","author":"Choi","year":"2000","journal-title":"J Ultrasound Med."},{"issue":"3","key":"10.3233\/THC-220685_ref18","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/jmri.21530","article-title":"Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound","volume":"29","author":"Tannus","year":"2009","journal-title":"J Magn Reson Imaging."},{"issue":"11","key":"10.3233\/THC-220685_ref19","first-page":"784","article-title":"Ultrasonic manifestation of pregnancy luteoma: A case report","volume":"18","author":"Gao","year":"2016","journal-title":"Journal of Clinical Ultrasound in Medicine."}],"container-title":["Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/THC-220685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:56:16Z","timestamp":1777614976000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/THC-220685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":19,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3233\/thc-220685","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,15]]}}}