{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:39:48Z","timestamp":1777891188674,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:p>BACKGROUND: At present, there are few studies related to mean nocturnal baseline impedance (MNBI), esophageal dynamic reflux monitoring, high-resolution esophageal manometry (HRM) parameter indexes, and its diagnostic value in gastroesophageal reflux disease (GERD). OBJECTIVE: To analyze the factors influencing MNBI and examine the diagnostic value of MNBI in GERD. METHODS: A retrospective analysis on 434 patients with typical reflux symptoms who underwent gastroscopy, 24-hour multichannel intraluminal impedance and pH monitoring (MII\/pH) and HRM. They were divided into the conclusive evidence group (103 cases), borderline evidence group (229 cases), and exclusion evidence group (102 cases) according to the level of diagnostic evidence of GERD based on the Lyon Consensus. We analyzed the differences in MNBI, esophagitis grade, MII\/pH and HRM index among the groups; the correlation between MNBI and the above indexes and its influence on MNBI; and to evaluate the diagnostic value of MNBI in GERD. RESULTS: There were significant differences in MNBI, Acid Exposure Time (AET) 4%, DeMeester score, and total reflux episodes among the three groups (P&lt; 0.001). EGJ contractile integral (EGJ-CI) of the conclusive evidence group and the borderline evidence group was significantly lower than that in the exclusion evidence group (P&lt; 0.001). MNBI was significantly and negatively correlated with age, BMI, AET 4%, DeMeester score, total reflux episodes, EGJ classification, esophageal motility abnormalities, and esophagitis grade (all P&lt; 0.05), and significantly and positively correlated with EGJ-CI (P&lt; 0.001). Age, BMI, AET 4%, EGJ classification, EGJ-CI, and esophagitis grade had significant effects on MNBI (P&lt; 0.05); MNBI was used to diagnose GERD with a diagnostic cutoff of 2061 \u03a9, and AUC was 0.792 (sensitivity 74.9%, specificity 67.4%); MNBI was used to diagnose exclusion evidence group with a diagnostic cutoff of 2432 \u03a9, AUC was 0.774 (sensitivity 67.6%, specificity 72%). CONCLUSION: AET, EGJ-CI, and esophagitis grade are the most important influence factors of MNBI. MNBI has good diagnostic value in identifying conclusive GERD.<\/jats:p>","DOI":"10.3233\/thc-220814","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T12:39:58Z","timestamp":1679661598000},"page":"1875-1886","source":"Crossref","is-referenced-by-count":6,"title":["Mean nocturnal baseline impedance: Influencing factors and diagnostic value in gastroesophageal reflux disease"],"prefix":"10.1177","volume":"31","author":[{"given":"Ning","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Digestive Diseases, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Hao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Digestive Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/THC-220814_ref1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2016-313589","article-title":"Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: A meta-analysis","volume":"67","author":"Leonardo","year":"2018","journal-title":"Gut"},{"issue":"7","key":"10.3233\/THC-220814_ref2","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1136\/gutjnl-2017-314722","article-title":"Modern diagnosis of GERD: The Lyon Consensus","volume":"67","author":"Gyawali","year":"2018","journal-title":"Gut"},{"issue":"2","key":"10.3233\/THC-220814_ref3","first-page":"141","article-title":"Interpretation of the 2018 Lyon Consensus on Gastroesophageal reflux Disease. [In Chinese]","volume":"39","author":"Ding","year":"2019","journal-title":"Chinese Journal of Digestion"},{"issue":"4","key":"10.3233\/THC-220814_ref4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.5056\/jnm19056","article-title":"Role of esophageal mean nocturnal baseline impedance and post-reflux swallow-induced peristaltic wave index in discriminating Chinese patients with heartburn","volume":"25","author":"Ya","year":"2019","journal-title":"J Neurogastroenterol Motil"},{"key":"10.3233\/THC-220814_ref5","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.cgh.2014.11.035","article-title":"Association between baseline impedance values and response proton pump inhibitors in patients with heartburn","volume":"13","author":"Nicola de","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.3233\/THC-220814_ref6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cgh.2015.06.026","article-title":"Analyses of the post-reflux swallowinduced peristaltic wave index and nocturnal baseline impedance parameters increase the diagnostic yield of impedance-ph monitoring of patients with reflux disease","volume":"14","author":"Frazzoni","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.3233\/THC-220814_ref7","unstructured":"Gastrointestinal Motility Group, Chinese Society of Gastroenterology, Chinese Medical Association, Greater China; Gastrointestinal Motility Expert Alliance; Xiao Yinglian; Chen Minhu. Clinical guideline for esophageal ambulatory reflux monitoring in adults. Chinese Journal of Digestion. 2021; 3: 149-158."},{"key":"10.3233\/THC-220814_ref8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5056\/jnm17032","article-title":"Esophageal baseline impedance reflects mucosal integrity and predicts symptomatic outcome with proton pump inhibitor treatment","volume":"24","author":"Xie","year":"2018","journal-title":"Journal of Neurogastroenterology and Motility"},{"issue":"2","key":"10.3233\/THC-220814_ref9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/gut.45.2.172","article-title":"Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification","volume":"45","author":"Lundell","year":"1999","journal-title":"Gut."},{"issue":"1","key":"10.3233\/THC-220814_ref10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cgh.2015.06.026","article-title":"Analyses of the post-reflux swallow-induced peristaltic wave index and nocturnal baseline impedance parameters increase the diagnostic yield of impedance-ph monitoring of patients with reflux disease","volume":"14","author":"Frazzoni","year":"2016","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.3233\/THC-220814_ref11","unstructured":"Gastroenterology Branch of Chinese Medical Association. Clinical guideline for esophageal ambulatory reflux monitoring in adults. Chinese Journal of Digestion. 2021; 3(41): 149-158."},{"key":"10.3233\/THC-220814_ref12","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254-1432.2017.02.017"},{"key":"10.3233\/THC-220814_ref13","unstructured":"Gastroenterology Branch of Chinese Medical Association. Chinese expert consensus of gastroesophageal reflux disease in 2020. Chinese Journal of Digestion. 2020; 40(10): 649-663."},{"issue":"9","key":"10.3233\/THC-220814_ref14","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.14309\/ajg.0000000000000734","article-title":"ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing","volume":"115","author":"Gyawali","year":"2020","journal-title":"Am J Gastroenterol."},{"issue":"5","key":"10.3233\/THC-220814_ref15","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nrgastro.2017.130","article-title":"Advances in the physiological assessment and diagnosis of GERD","volume":"15","author":"Savarino","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.3233\/THC-220814_ref16","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1136\/gut.2010.233049","article-title":"Evaluation of oesophageal mucosa integrity by the intralumina l impedance technique","volume":"60","author":"Farr\u00e9","year":"2011","journal-title":"Gut."},{"issue":"9","key":"10.3233\/THC-220814_ref17","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1136\/gutjnl-2012-302645","article-title":"In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease","volume":"62","author":"Philip","year":"2013","journal-title":"Gut."},{"issue":"5","key":"10.3233\/THC-220814_ref18","first-page":"601","article-title":"Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease","volume":"48","author":"Chanjuan","year":"2013","journal-title":"Gastroenterol."},{"issue":"8","key":"10.3233\/THC-220814_ref19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/apt.13777","article-title":"Distal mean nocturnal baseline impedance on pH-impedance monitoring predicts reflux burden and symptomatic outcome in gastro-oesophageal reflux disease","volume":"44","author":"Patel","year":"2016","journal-title":"Aliment Pharmacol Ther."},{"issue":"3","key":"10.3233\/THC-220814_ref20","doi-asserted-by":"crossref","first-page":"e13752","DOI":"10.1111\/nmo.13752","article-title":"Correlation between reflux burden, peristaltic function, and mucosal integrity in GERD patients","volume":"32","author":"Ribolsi","year":"2020","journal-title":"Neurogastr.oenterol Motil."},{"issue":"1","key":"10.3233\/THC-220814_ref21","doi-asserted-by":"publisher","first-page":"15076","DOI":"10.1038\/s41598-021-94149-w","article-title":"Correlation between gastroesophageal flap valve abnormality and novel parameters in patients with gastroesophageal reflux disease symptoms by the lyon consensus","volume":"11","author":"Guo","year":"2021","journal-title":"Sci Rep."},{"key":"10.3233\/THC-220814_ref22","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.dld.2017.04.005","article-title":"Esophageal chemical clearance and baseline impedance values in patients with chronic autoimmune atrophic gastritis and gastro-esophageal reflux disease","volume":"49","author":"Tenca","year":"2017","journal-title":"Digestive and Liver Disease: Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver."},{"key":"10.3233\/THC-220814_ref23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1159\/000490790","article-title":"Convenient method of measuring baseline impedance for distinguishing patients with functional heartburn from those with proton pump inhibitor-resistant endoscopic negative reflux disease","volume":"99","author":"Yoshimine","year":"2019","journal-title":"Digestion."},{"key":"10.3233\/THC-220814_ref24","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/nmo.12299","article-title":"Esophageal baseline impedance levels in patients with pathophysiological characteristics of functional heartburn","volume":"26","author":"Martinucci","year":"2014","journal-title":"Neurogastroenterol Motil."},{"key":"10.3233\/THC-220814_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13116"},{"issue":"1","key":"10.3233\/THC-220814_ref26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.5056\/jnm17032","article-title":"Esophageal baseline impedance reflects mucosal integrity and predicts symptomatic outcome with proton pump inhibitor treatment","volume":"24","author":"Chenxi","year":"2018","journal-title":"Neurogastroenterol Motil."}],"container-title":["Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/THC-220814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:56:32Z","timestamp":1777614992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/THC-220814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":26,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3233\/thc-220814","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,15]]}}}