{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:40:29Z","timestamp":1777891229092,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2024,5,10]]},"abstract":"<jats:p>BACKGROUND: Elastomeric pumps have a curved infusion rate profile over infusion time. Chemically driven pumps can overcome such limitations of elastomeric pumps and infuse constantly. However, studies on the pharmacokinetic benefit of chemically-driven pumps are insufficient. OBJECTIVE: This study aimed to determine effects of constant infusion with a chemically-driven pump on plasma drug concentrations compared to elastomeric pumps. METHODS: Infusion rate profiles of a chemically driven pump and two elastomeric pumps were measured in vitro tests under three height conditions of drug reservoir. Plasma drug concentrations were estimated using a pharmacokinetic model of 5-fluorouracil (5FU). RESULTS: The chemically-driven pump was more accurate than elastomeric pumps during the total infusion time (Root-mean-square-error (RMSE): 3% vs. 13%) which thus reduced its deviation of plasma 5FU concentration over time to one-fifth of that with an elastomeric pump. The chemically-driven pump had less than 5% of RMSE despite the influence of height difference. CONCLUSION: Although chemically-driven pumps maintained plasma 5FU concentration successfully and elastomeric pumps did not, both pumps were proper for 5FU infusion because the time-dependent changes in infusion rate did not affect the area under the curve. Chemically driven pumps would be more advantageous for drugs that are sensitive to their plasma concentrations.<\/jats:p>","DOI":"10.3233\/thc-230227","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:09:05Z","timestamp":1695985745000},"page":"1351-1360","source":"Crossref","is-referenced-by-count":0,"title":["Effects of flow rate accuracy in two-day anticancer drug infusion with disposable pumps on plasma drug concentrations"],"prefix":"10.1177","volume":"32","author":[{"given":"Kyoung Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Bioengineering, Seoul National University Graduate School, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Institute of Medical and Biological Engineering, Medical 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