{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:40:44Z","timestamp":1777891244780,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2023,11,16]]},"abstract":"<jats:p>BACKGROUND: At present, the pathogenesis of post-stroke insomnia (PSI) is still inconclusive. OBJECTIVE: To explore the changes and significance of serum cholecystokinin-8 (CCK-8), substance P (SP), and 5-hydroxytryptamine (5-HT) in patients with PSI. METHODS: Ninety-one patients with stroke were selected as the research subjects, and according to the score of the Athens Insomnia Scale (AIS), they were divided into the insomnia group and the non-insomnia group. The serum levels of CCK-8, SP, and 5-HT in the two groups were compared to explore their relationships with PSI. RESULTS: Among the 91 patients, 56 were in the insomnia group and 35 were in the non-insomnia group, and the incidence of insomnia was 61.5%. There was no significant difference in the serum levels of CCK-8, SP, and 5-HT between the two groups (P= 0.696, 0.980, and 0.809, respectively). One-way analysis of variance showed that there was no significant correlation between the serum levels of CCK-8, SP, 5-HT, and the AIS score (P= 0.7393, 0.9581, and 0.5952, respectively). CONCLUSION: The incidence of PSI was relatively high, but it could not be proved that CCK-8, SP, and 5-HT were involved in the pathogenesis of PSI. There might exist other neurotransmitters involved in the pathophysiological process of PSI, which should be further explored.<\/jats:p>","DOI":"10.3233\/thc-230506","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T12:22:43Z","timestamp":1689682963000},"page":"2355-2361","source":"Crossref","is-referenced-by-count":2,"title":["An investigation on the changes of serum CCK-8, substance P, and 5-HT in patients with post-stroke insomnia"],"prefix":"10.1177","volume":"31","author":[{"given":"Xiao-Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Shenzhen Dapeng New District Nanao People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Shenzhen Dapeng New District Nanao People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ye","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital, Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Chun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Shenzhen Dapeng New District Nanao People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Lan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Shenzhen Dapeng New District Nanao People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital, Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital, Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"2","key":"10.3233\/THC-230506_ref1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1161\/STROKEAHA.120.029847","article-title":"Dynamic prevalence of sleep disorders following stroke or transient ischemic attack: Systematic review and meta-analysis","volume":"52","author":"Hasan","year":"2021","journal-title":"Stroke."},{"issue":"1","key":"10.3233\/THC-230506_ref2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5853\/jos.2017.02887","article-title":"Sleep disturbances as a risk factor for stroke","volume":"20","author":"Koo","year":"2018","journal-title":"J Stroke."},{"issue":"12","key":"10.3233\/THC-230506_ref3","doi-asserted-by":"publisher","first-page":"6783","DOI":"10.1007\/s10072-022-06349-5","article-title":"Repetitive transcranial magnetic stimulation (rTMS) for post-stroke sleep disorders: A systematic review of randomized controlled trials","volume":"43","author":"Guo","year":"2022","journal-title":"Neurol Sci."},{"issue":"4","key":"10.3233\/THC-230506_ref4","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1161\/STROKEAHA.119.028796","article-title":"Embolic stroke of undetermined source and sleep disorders","volume":"51","author":"Dharmakulaseelan","year":"2020","journal-title":"Stroke."},{"key":"10.3233\/THC-230506_ref5","doi-asserted-by":"publisher","first-page":"101222","DOI":"10.1016\/j.smrv.2019.101222","article-title":"Incidence and prevalence of post-stroke insomnia: A systematic review and meta-analysis","volume":"49","author":"Baylan","year":"2020","journal-title":"Sleep Med Rev."},{"issue":"10","key":"10.3233\/THC-230506_ref6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11910-018-0879-6","article-title":"Sleep-wake disorders in stroke-increased stroke risk and deteriorated recovery? 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