{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:50:35Z","timestamp":1781761835313,"version":"3.54.5"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2024,5]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Chronic obstructive pulmonary disease (COPD) is one of the most common chronic airway diseases in the world.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n \n To predict the degree of mixed venous oxygen saturation (SvO\n 2<\/jats:sub>\n ) impairment in patients with COPD by modeling using clinical-CT radiomics data and to provide reference for clinical decision-making.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n A total of 236 patients with COPD diagnosed by CT and clinical data at Xiangyang No. 1 People\u2019s Hospital (\n \n \n \n n<\/mml:mi>\n =<\/mml:mo>\n \n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 157) and Xiangyang Central Hospital (\n \n \n \n n<\/mml:mi>\n =<\/mml:mo>\n \n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 79) from June 2018 to September 2021 were retrospectively analyzed. The patients were divided into group A (SvO\n \n \n \n \u2a7e<\/mml:mo>\n \n 2<\/mml:mn>\n \n <\/mml:mmultiscripts>\n <\/mml:math>\n <\/jats:inline-formula>\n 62%,\n \n \n \n N<\/mml:mi>\n =<\/mml:mo>\n \n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 107) and group B (SvO\n \n \n \n <<\/mml:mo>\n \n 2<\/mml:mn>\n \n <\/mml:mmultiscripts>\n <\/mml:math>\n <\/jats:inline-formula>\n 62%,\n \n \n \n N<\/mml:mi>\n =<\/mml:mo>\n \n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 129). We set up training set and test set at a ratio of 7\/3 and time cutoff spot; In training set, Logistic regression was conducted to analyze the differences in general data (e.g. height, weight, systolic blood pressure), laboratory indicators (e.g. arterial oxygen saturation and pulmonary artery systolic pressure), and CT radiomics (radscore generated using chest CT texture parameters from 3D slicer software and LASSO regression) between these two groups. Further the risk factors screened by the above method were used to establish models for predicting the degree of hypoxia in COPD, conduct verification in test set and create a nomogram.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Univariate analysis demonstrated that age, smoking history, drinking history, systemic systolic pressure, digestive symptoms, right ventricular diameter (RV), mean systolic pulmonary artery pressure (sPAP), cardiac index (CI), pulmonary vascular resistance (PVR), 6-min walking distance (6MWD), WHO functional classification of pulmonary hypertension (WHOPHFC), the ratio of forced expiratory volume in the first second to the forced vital capacity (FEV1%), and radscore in group B were all significantly different from those in group A (\n \n \n \n P<\/mml:mi>\n <<\/mml:mo>\n \n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 0.05). Multivariate regression demonstrated that age, smoking history, digestive symptoms, 6MWD, and radscore were independent risk factors for SvO\n 2<\/jats:sub>\n impairment. The combined model established based on the abovementioned indicators exhibited a good prediction effect [AUC: 0.903; 95%CI (0.858\u20130.937)], higher than the general clinical model [AUC: 0.760; 95%CI (0.701\u20130.813),\n \n \n \n P<\/mml:mi>\n <<\/mml:mo>\n \n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 0.05] and laboratory examination-radiomics model [AUC: 0.868; 95%CI (0.818\u20130.908),\n \n \n \n P<\/mml:mi>\n =<\/mml:mo>\n \n <\/mml:mrow>\n <\/mml:math>\n <\/jats:inline-formula>\n 0.012]. The newly created nomogram may be helpful for clinical decision-making and benefit COPD patients.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n SvO\n 2<\/jats:sub>\n is an important indicator of hypoxia in COPD, and it is highly related to age, 6MWD, and radscore. The combined model is helpful for early identification of SvO\n 2<\/jats:sub>\n impairment and adjustment of COPD treatment strategies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/thc-230619","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T10:46:09Z","timestamp":1694169969000},"page":"1569-1582","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting mixed venous oxygen saturation (SvO\n 2<\/sub>\n ) impairment in COPD patients using clinical-CT radiomics data: A preliminary study"],"prefix":"10.1177","volume":"32","author":[{"given":"Peng","family":"An","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxing","family":"Yu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hubei University of Arts and Science","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S128604"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-5885(18)30176-X"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00470-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12660"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/s22031024"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.846074"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000749"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01448-2018"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","unstructured":"Gali\u00e8N HumbertM VachieryJL et al. 2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC) International Society for Heart and Lung Transplantation (ISHLT). 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