{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:41:19Z","timestamp":1777891279200,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:p>BACKGROUND: Endometrial receptivity is crucial for the establishment of a healthy pregnancy outcome. Previous research on endometrial receptivity primarily examined endometrial thickness, endometrial echo types, and endometrial blood supply. OBJECTIVE: To explore the differences in the elastic modulus of the endometrium in women with various pregnancy outcomes by real-time shear wave elastography (SWE) and to investigate its application value in evaluation of endometrial receptivity. METHODS: A total of 205 pregnant women who were admitted at Wenzhou People\u2019s Hospital between January 2021 and December 2022 were selected. Three-dimensional transvaginal sonography and real-time shear wave elastography were performed in the proliferative phase and receptive phase of the endometrium, and the average elastic modulus of the endometrium in the two phases was obtained and compared. According to whether the pregnancy was successful or not, the participants were divided into the pregnancy group (n= 72) and non-pregnancy group (n= 133), and the differences in intimal thickness, 3D blood flow parameters, and average elastic modulus of intima were compared between the two groups. RESULTS: The average elastic modulus of the endometrium in the proliferative phase and receptive phase was (23.92 \u00b1 2.31) kPa and (11.82 \u00b1 2.24) kPa, respectively, and the difference was statistically significant P&lt; 0.05. The average elastic modulus of the endometrium in the pregnancy group and non-pregnancy group was (9.97 \u00b1 1.08) kPa and (12.82 \u00b1 2.06) kPa, respectively, and the difference was statistically significant P&lt; 0.05. The area under the curve of predicting pregnancy by the average elastic modulus of the endometrium in the receptive phase was 0.888 (0.841\u223c0.934), with corresponding P value &lt; 0.05. The critical value was 11.15, with a corresponding sensitivity of 81.7% and specificity of 78.2%. CONCLUSION: Real-time shear wave elastography can quantitatively evaluate endometrial elasticity, indirectly reflect the endometrial phase, and provide a new diagnostic concept for evaluating endometrial receptivity and predicting pregnancy outcome in infertile patients.<\/jats:p>","DOI":"10.3233\/thc-231106","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T10:38:40Z","timestamp":1707475120000},"page":"2345-2352","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary application of real-time shear wave elastography to evaluate endometrial receptivity and predict pregnancy outcome"],"prefix":"10.1177","volume":"32","author":[{"given":"Cai-Cha","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Ultrasonography, Wenzhou Peoples\u2019 Hospital, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Ultrasonography, Wenzhou Peoples\u2019 Hospital, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Ultrasonography, Wenzhou Peoples\u2019 Hospital, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Si","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Ultrasonography, Wenzhou Peoples\u2019 Hospital, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Hangzhou Women\u2019s Hospital, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"2","key":"10.3233\/THC-231106_ref1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: A systematic review and meta-analysis","volume":"25","author":"Craciunas","year":"2019","journal-title":"Hum Reprod Update."},{"key":"10.3233\/THC-231106_ref2","doi-asserted-by":"crossref","unstructured":"MACKENSS, SANTOS-RIBEIROS. Frozen embryo transfer: A review on the optimal endometrial preparation and timing. Human Reproduction. 2017; 32(11): 2234-2242.","DOI":"10.1093\/humrep\/dex285"},{"issue":"2","key":"10.3233\/THC-231106_ref3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/jum.15981","article-title":"Quantitative evaluation of the normal cervix, cervical cancer, and cervical precancerous changes via real-time shear wave elastography","volume":"42","author":"Guo","year":"2023","journal-title":"J Ultrasound Med."},{"issue":"1","key":"10.3233\/THC-231106_ref4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12880-023-01020-7","article-title":"Evaluation of the stiffness of normal cervix and its change with different factors using transvaginal two-dimensional shear wave elastography under strict quality control","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Med Imaging."},{"issue":"S1","key":"10.3233\/THC-231106_ref5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3233\/THC-228049","article-title":"Evaluation of menopausal endometrial lesions via mathematical modeling clinical indicators and ultrasonographic parameters","volume":"30","author":"Zhu","year":"2022","journal-title":"Technol Health Care."},{"key":"10.3233\/THC-231106_ref6","doi-asserted-by":"publisher","DOI":"10.3233\/THC-230332"},{"key":"10.3233\/THC-231106_ref7","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.2147\/IJGM.S312292","article-title":"Transvaginal real-time shear wave elastography in the diagnosis of endometrial lesions","volume":"14","author":"Du","year":"2021","journal-title":"Int J Gen Med."},{"issue":"1","key":"10.3233\/THC-231106_ref8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13244-020-0841-4","article-title":"Assessment of early damage of endometrium after artificial abortion by shear wave elastography","volume":"11","author":"Jiao","year":"2020","journal-title":"Insights Imaging."},{"issue":"3","key":"10.3233\/THC-231106_ref9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.fertnstert.2019.05.001","article-title":"Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers","volume":"112","author":"Haas","year":"2019","journal-title":"Fertility and Sterility"},{"issue":"3","key":"10.3233\/THC-231106_ref10","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.fertnstert.2015.05.036","article-title":"Endometrial pattern, but not endometrial thickness, affects implantation rates in euploid embryo transfers","volume":"104","author":"Gingold","year":"2015","journal-title":"Fertility and Sterility"},{"issue":"1","key":"10.3233\/THC-231106_ref11","first-page":"1","article-title":"Subendometrial resistence and pulsatility index assessment of endometrial receptivity in assisted reproductive technology cycles","volume":"17","author":"Martins","year":"2019","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.3233\/THC-231106_ref12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s13224-016-0871-5","article-title":"Endometrial and subendometrial vascularity by three-dimensional (3D) power doppler and its correlation with pregnancy outcome in frozen embryo transfer (FET) cycles","volume":"66","author":"Mishra","year":"2016","journal-title":"J Obstet Gynaecol India"},{"key":"10.3233\/THC-231106_ref13","first-page":"2678","article-title":"Preliminary application of real-time shear wave elastography in evaluating endometrial receptivity","volume":"21","author":"Yu","year":"2020","journal-title":"Chin Gen Prac."},{"key":"10.3233\/THC-231106_ref14","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1016\/j.ultrasmedbio.2019.06.421","article-title":"Conventional US and 2-D shear wave elastography of virtual touch tissue imaging quantification: Correlation with immunohistochemical subtypes of breast cancer","volume":"45","author":"Liu","year":"2019","journal-title":"Ultrasound Med Biol."},{"key":"10.3233\/THC-231106_ref15","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1007\/s00261-017-1375-1","article-title":"Shear wave liver elastography","volume":"43","author":"Barr","year":"2018","journal-title":"Abdom Radiol (NY)."}],"container-title":["Technology and Health Care"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/THC-231106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:59:05Z","timestamp":1777615145000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/THC-231106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,12]]},"references-count":15,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/thc-231106","relation":{},"ISSN":["0928-7329","1878-7401"],"issn-type":[{"value":"0928-7329","type":"print"},{"value":"1878-7401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,12]]}}}