{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:37:00Z","timestamp":1789605420811,"version":"build-2803163510"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2023,4,28]]},"abstract":"<jats:p>BACKGROUND: The incidence rate for migraine is 12% worldwide, and recurrence is common, which seriously affects the physical and mental health of patients. OBJECTIVE: To observe the clinical effect of Shallow Puncture and More Twirling method of acupuncture in treating migraine and its impact on serum 5-HT and \u03b2-EP. METHODS: A total of 76 patients with migraine were randomized into a control group and acupuncture group with 38 cases in each. In the control group, patients were orally administered flunarizine hydrochloride before sleep, 2 capsules once daily for 4 weeks. In the acupuncture group, Shallow Puncture and More Twirling method was adopted for the acupoints of Sizhukong (SJ 23), Toulinqi (GB 15) Shuaigu (GB 8), Xuanlu (GB 5), Fengchi (GB 20), Waiguan (SJ 5), Zulinqi (GB 41). Patients were given acupuncture 3 times per week for 4 weeks. Then, the total VAS (Visual Analogue Scale) scores, composite score of migraine, serum level of 5-HT and \u03b2-EP, and the clinical efficacy differences were observed before and after treatment and the side-effects were recorded among the two groups. RESULTS: The total VAS scores and composite score of migraine were significantly reduced among both groups after the treatment (P&lt; 0.05), and the serum level of 5-HT and \u03b2-EP was significantly improved (P&lt; 0.05). Compared with control group, the acupuncture group reported lower results in VAS score and migraine composite score (P&lt; 0.05), and higher results in serum 5-HT and \u03b2-EP level (P&lt; 0.05). The acupuncture group with shallow puncture and more twirling method showed a total effective rate of 86.5%, which is higher than the control group (78.4%). The difference is statistically significant (P&lt; 0.05). CONCLUSION: Shallow Puncture and More Twirling method was superior to flunarizine hydrochloride in the treatment of clinical symptoms of migraine. Acupuncture also increases the serum level of 5-HT and \u03b2-EP in migraine.<\/jats:p>","DOI":"10.3233\/thc-236047","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T11:45:25Z","timestamp":1680867925000},"page":"533-540","source":"Crossref","is-referenced-by-count":13,"title":["Clinical efficacy of the shallow puncture and more-twirling acupuncture method in migraine treatment and its effects on serum 5-HT and \u03b2-EP levels"],"prefix":"10.1177","volume":"31","author":[{"given":"Xin-Xin","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/THC-236047_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"10.3233\/THC-236047_ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s10194-016-0593-1","article-title":"Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients","volume":"17","author":"Gomez-Beldarrain","year":"2015","journal-title":"J Headache Pain."},{"issue":"8","key":"10.3233\/THC-236047_ref3","first-page":"151","article-title":"Clinical Efficacy of Flunarizine Combined with Tongtongning Capsule in Treatment of Migraine and Its Effect on Serum Levels of TNF-\u03b1, ICAM-1 and CGRP","volume":"40","author":"Ye","year":"2022","journal-title":"Chinese Archives of Traditional Chinese Medicine."},{"issue":"1","key":"10.3233\/THC-236047_ref4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S1474-4422(14)70193-0","article-title":"Functional MRI of migraine","volume":"14","author":"Schwedt","year":"2015","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.3233\/THC-236047_ref5","first-page":"2249","article-title":"Dynamic study on clinical effect and inflammatory cytokines of qianyang anshen decoction in migraine patients with anxiety","volume":"37","author":"Ye","year":"2019","journal-title":"Chinese Archives of Traditional Chinese Medicine."},{"issue":"4","key":"10.3233\/THC-236047_ref6","first-page":"918","article-title":"Study about influence of brain metabolism in patients with chronic migraine after acupuncture at shaoyang specific acupoints","volume":"34","author":"Liang","year":"2016","journal-title":"Chinese Archives of Traditional Chinese Medicine."},{"issue":"3","key":"10.3233\/THC-236047_ref7","first-page":"176","article-title":"Research progress on chronic migraine","volume":"17","author":"Qin","year":"2011","journal-title":"Chinese Journal of Pain Medicine."},{"issue":"5","key":"10.3233\/THC-236047_ref8","first-page":"154","article-title":"Chen lei\u2019s experience of shallow puncture and more twirling method of acupuncture in treating migraine","volume":"53","author":"Li","year":"2021","journal-title":"Journal of New Chinese Medicine."},{"issue":"1","key":"10.3233\/THC-236047_ref9","first-page":"37","article-title":"Analgesic effect of shallow puncture and more twirling method of acupuncture on the acute phase of migraine without aura","volume":"57","author":"Wang","year":"2022","journal-title":"Zhejiang Journal of Traditional Chinese Medicine."},{"issue":"23","key":"10.3233\/THC-236047_ref11","first-page":"2042","article-title":"Experience in the treatment of migraine by using the method of draining wind and phlegm and removing stasis","volume":"62","author":"Xiao","year":"2021","journal-title":"Journal of Traditional Chinese Medicine."},{"issue":"6","key":"10.3233\/THC-236047_ref12","first-page":"2002","article-title":"Discussing the treatment of migraine from the nine methods of liver","volume":"30","author":"Zhang","year":"2015","journal-title":"Chinese Journal of Traditional Chinese Medicine."},{"issue":"3","key":"10.3233\/THC-236047_ref13","first-page":"412","article-title":"Research on acupoint selection law of acupuncture in the treatment of migraine based on data mining","volume":"29","author":"Wang","year":"2020","journal-title":"Chinese Journal of Emergency Medicine."},{"issue":"4","key":"10.3233\/THC-236047_ref14","first-page":"307","article-title":"Based on data mining technology, the acupuncture rule of simple acupuncture for the treatment of migraine was analyzed","volume":"19","author":"Wang","year":"2021","journal-title":"Chinese Journal of Integrative Imaging of Traditional and Western Medicine."},{"issue":"2","key":"10.3233\/THC-236047_ref15","first-page":"115","article-title":"The effects of acupuncture on pain and cerebral hemodynamics in patients with migraine: A randomized controlled study","volume":"4","author":"Deng","year":"2021","journal-title":"Chinese Acupuncture."},{"issue":"4","key":"10.3233\/THC-236047_ref16","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/jamainternmed.2016.9378","article-title":"The long-term effect of acupuncture for migraine prophylaxis: A randomized clinical trial","volume":"177","author":"Zhao","year":"2017","journal-title":"JAMA Intern Med."},{"issue":"17","key":"10.3233\/THC-236047_ref17","first-page":"714","article-title":"Pathogenesis and progress in the diagnosis and treatment of migraine","volume":"5","author":"Zhou","year":"2019","journal-title":"Chinese Journal of General Practice."},{"issue":"11","key":"10.3233\/THC-236047_ref18","first-page":"2117","article-title":"Efficacy of Chuanxiong Chatiao San in Treating Migraine and Its Effect on \u03b2-EP and 5-HT","volume":"25","author":"Sun","year":"2016","journal-title":"Journal of Emergency in Traditional Chinese Medicine."},{"issue":"1","key":"10.3233\/THC-236047_ref19","first-page":"33","article-title":"Research trend of acupuncture analgesia mechanism in the new period","volume":"21","author":"Zhu","year":"2012","journal-title":"Journal of Emergency in Traditional Chinese Medicine."},{"issue":"1","key":"10.3233\/THC-236047_ref20","first-page":"9","article-title":"Acupuncture analgesia: Consensus and questioning","volume":"17","author":"Han","year":"2011","journal-title":"Chinese Journal of Pain Medicine."},{"issue":"1","key":"10.3233\/THC-236047_ref21","first-page":"95","article-title":"Research progress on the action mechanism of acupuncture in treating migraine","volume":"32","author":"Wu","year":"2016","journal-title":"Journal of Practical Traditional Chinese Medicine."}],"container-title":["Technology and Health 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