{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:42:31Z","timestamp":1777891351891,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The human oral cavity contains over 700 types of bacteria that may protect the body against colonization by exogenous pathogens and maintain relative homeostasis. However, alterations in the immune status can disrupt the balance between microorganisms and the host, inducing various diseases such as oral cancer and diabetes mellitus. The mechanism underlying this process is not clearly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the relationships between subgingival bacteria, T-cell receptor [Formula: see text]-chain complementarity-determining region 3 (TCR[Formula: see text] CDR3), and the development oforal squamous cell carcinoma (OSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We grouped patients as \u201chealthy periodontal\u201d (H), \u201cmoderate-to-severe chronic periodontitis\u201d (C), and \u201cmoderate-to-severe chronic periodontitis with OSCC\u201d (T). Bacterial groups were \u201csubgingival plaque\u201d (bp) and \u201cgingival\/tumor tissue\u201d (g). We also recorded patients\u2019 age, gender, attachment level (AL), bleeding on probing (BOP), and probing depth (PD). We extracted and sequenced RNA from plaques, gingival tissues, tumors, and teeth. We performed high-throughput sequencing on TCR[Formula: see text] CDR3 and plaque bacteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Synergistetes and Veillonella parvula were more abundant in the H group than in the T group. Granulicatella, Peptostreptococcus, and Streptococcus infantis were enriched in the T-bp group. AL, BOP, and PD were positively correlated with Granulicatella, Peptostreptococcus, and Pseudomonas but negatively correlated with Prevotella nigrescens and V. parvula. TCR[Formula: see text] CDR3 diversity was C [Formula: see text] H [Formula: see text] T. TCR [Formula: see text]-chain Variable gene (TRBV)20-1 usage varied among the H, C, and T groups. TRBV2 and TRBV5-1 usage was greater in the T group than in the C group. TRBJ1-1, TRBJ1-2, TRBJ2-2, TRBJ2-7, and TRBJ2-5 were most frequently used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>These trends and the reduction of gingival Synergistetes were correlated with OSCC. TCR[Formula: see text] CDR3 diversity was the lowest in patients in the T group, and there were considerable changes in the expression of TRBV2 and TRBJ. Therefore, plaque bacterial composition can influence TCR[Formula: see text] CDR3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/thc-240218","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T10:28:34Z","timestamp":1727432914000},"page":"25-51","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Microbial community composition in subgingival plaques and heterogeneity of tumor tissue TCR\u03b2 CDR3 repertoire in patients with moderate-to-severe periodontitis and oral squamous cell carcinoma"],"prefix":"10.1177","volume":"33","author":[{"given":"Jie","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Periodontics, Zunyi Medical University Affiliated Stomatological Hospital, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Zunyi Medical University Affiliated Stomatological Hospital, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Zunyi Medical University Affiliated Stomatological Hospital, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanmin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Zunyi Medical University Affiliated Stomatological Hospital, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Zunyi Medical University Affiliated Stomatological Hospital, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"bibr1-THC-240218","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-31248-4_4"},{"key":"bibr2-THC-240218","doi-asserted-by":"publisher","DOI":"10.4103\/wjtcm.wjtcm_34_21"},{"key":"bibr3-THC-240218","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-022-00163-7"},{"key":"bibr4-THC-240218","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ebd.6401037"},{"key":"bibr5-THC-240218","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4526"},{"key":"bibr6-THC-240218","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111558"},{"key":"bibr7-THC-240218","first-page":"1","volume":"00","author":"Wang J","year":"2024","journal-title":"J Periodontal Res."},{"key":"bibr8-THC-240218","first-page":"S13","author":"Gorentla BK","year":"2012","journal-title":"The Journal of Clinical & Cellular 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