{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:13:17Z","timestamp":1782364397412,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["THC"],"published-print":{"date-parts":[[2024,11,8]]},"abstract":"<jats:p>BACKGROUND: Oral cancer has a high worldwide incidence and mortality rate showing an upward trend year by year, predominantly occurring in emerging countries. Oral squamous cell carcinoma (OSCC) is one of the main types of oral cancer, accounting for more than 90% of all cases in oral cancer. OBJECTIVE: To evaluate the diagnostic value of 8-hydroxy-2\u2019-deoxyguanosine (8-OHdG), 8-iso-Prostaglandin F2alpha (8-iso-PGF2\u03b1) and tumor necrosis factor (TNF)-\u03b1 as biomarkers in the early carcinogenesis of erosive oral lichen planus (EOLP) by measuring their levels in the blood of patients with EOLP and oral squamous cell carcinoma (OSCC). METHODS: A total of 69 patients were enrolled in this case-control study [including an OSCC group (n= 23), an EOLP group (n= 23), and an age- and gender-matched healthy control group (n= 23)]. Blood levels of 8-OHdG, 8-iso-PGF2\u03b1 and TNF-\u03b1 were measured using enzyme-linked immunosorbent assay (ELISA). Statistical differences in these indicators among the three groups were analyzed. RESULTS: Plasma levels of 8-OHdG and 8-iso-PGF2\u03b1 in the OSCC group were significantly higher than those in both the EOLP group and the control group (all P&lt; 0.05); no significant statistical difference was found between the EOLP group and the control group. Serum levels of TNF-\u03b1 in both the OSCC and EOLP groups were elevated compared with the control group, showing significant differences among all three groups (all P&lt; 0.05). Receiver operating characteristic (ROC) curves revealed that plasma 8-OHdG and 8-iso-PGF2\u03b1 levels and serum TNF-\u03b1 levels had diagnostic effects on early carcinogenesis in EOLP patients. When these indicators were combined for diagnosis, the diagnostic effect was enhanced, with an area under the ROC curve (AUC) values of 0.819. CONCLUSION: 8-OHdG, 8-iso-PGF2\u03b1 and TNF-\u03b1 may serve as biological indicators for monitoring the early carcinogenesis of EOLP, and the diagnostic effect was augmented when these indicators were combined.<\/jats:p>","DOI":"10.3233\/thc-240930","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T09:45:06Z","timestamp":1722591906000},"page":"4695-4705","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic value of 8-OHdG, 8-iso-PGF2\u03b1 and TNF-\u03b1 levels in blood for early carcinogenesis of erosive oral lichen planus"],"prefix":"10.1177","volume":"32","author":[{"given":"Feifei","family":"Gong","sequence":"first","affiliation":[{"name":"Stomatology Department, Ma\u2019anshan People\u2019s Hospital, Ma\u2019anshan, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Stomatology Department, Ma\u2019anshan People\u2019s Hospital, Ma\u2019anshan, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixuan","family":"Shan","sequence":"additional","affiliation":[{"name":"Bengbu Medical University, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Stomatology Department, Ma\u2019anshan People\u2019s Hospital, Ma\u2019anshan, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huakuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Stomatology Department, Ma\u2019anshan People\u2019s Hospital, Ma\u2019anshan, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Tang","sequence":"additional","affiliation":[{"name":"Stomatology Department, Ma\u2019anshan People\u2019s Hospital, Ma\u2019anshan, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/THC-240930_ref1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.21775\/cimb.037.047","article-title":"A Review on Salivary Proteomics for Oral Cancer Screening","volume":"37","author":"Li","year":"2020","journal-title":"Curr Issues Mol Biol."},{"key":"10.3233\/THC-240930_ref2","doi-asserted-by":"publisher","first-page":"825266","DOI":"10.3389\/fphar.2022.825266","article-title":"Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer","volume":"13","author":"Kumari","year":"2022","journal-title":"Front Pharmacol."},{"key":"10.3233\/THC-240930_ref3","doi-asserted-by":"publisher","first-page":"122065","DOI":"10.1016\/j.lfs.2023.122065","article-title":"Mitochondria in oral cancer stem cells: Unraveling the potential drug targets for new and old drugs","volume":"331","author":"Olmedo","year":"2023","journal-title":"Life Sci."},{"key":"10.3233\/THC-240930_ref4","doi-asserted-by":"publisher","first-page":"104550","DOI":"10.1016\/j.oraloncology.2019.104550","article-title":"Oral potentially malignant disorders: A comprehensive review on clinical aspects and management","volume":"102","author":"Warnakulasuriya","year":"2020","journal-title":"Oral Oncol."},{"key":"10.3233\/THC-240930_ref5","doi-asserted-by":"publisher","first-page":"104550","DOI":"10.1016\/j.oraloncology.2019.104550","article-title":"Oral potentially malignant disorders: A comprehensive review on clinical aspects and management","volume":"102","author":"Warnakulasuriya","year":"2020","journal-title":"Oral Oncol."},{"issue":"6","key":"10.3233\/THC-240930_ref6","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.21873\/anticanres.12587","article-title":"Potentially Malignant Oral Disorders and Cancer Transformation","volume":"38","author":"Ganesh","year":"2018","journal-title":"Anticancer Res."},{"key":"10.3233\/THC-240930_ref7","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1472-6831-14-99","article-title":"Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders","volume":"14","author":"Wang","year":"2014","journal-title":"BMC Oral Health."},{"key":"10.3233\/THC-240930_ref8","unstructured":"Chen QM. 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