{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:18:00Z","timestamp":1777889880954,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Fondaparinux sodium can prevent and treat acute illnesses and venous thromboembolism in patients undergoing surgery. At present, no studies have reported on treating subchorionic hematoma combined with protein S deficiency using fondaparinux sodium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To investigate the clinical efficacy of fondaparinux sodium in the treatment of patients with subchorionic hematoma combined with protein S deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This single-center, open-ended, and prospective study enrolled 78 patients with subchorionic hematoma and protein S deficiency. They were randomly assigned to the treatment and control groups. The control group received conventional treatment, and the observation group received subepithelial injections of fondaparinux sodium (2.5 mg\/day) based on conventional treatment. After 30 days of continuous treatment, the hematoma was evaluated by ultrasonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>After treatment with fondaparinux sodium, a significant improvement in subchorionic hematoma was observed in the observation group compared with that in the control group ([Formula: see text] 0.05). A substantial improvement in prothrombin time and activated partial thromboplastin time was observed in the observation group after fondaparinux sodium treatment ([Formula: see text] 0.05). Furthermore, after fondaparinux sodium treatment, the duration of hematoma maintenance and incidence of adverse pregnancy outcomes were significantly reduced in the observation group compared with that in the control group ([Formula: see text] 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>With a favorable safety profile, fondaparinux sodium is effective in treating subchorionic hematoma combined with protein S deficiency. The results provide new ideas and methods for treating this disease, which is worthy of further promotion and application in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/thc-241035","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T11:51:13Z","timestamp":1725364273000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Fondaparinux sodium combined with conventional therapy improves subchorionic hematoma with protein S deficiency"],"prefix":"10.1177","volume":"33","author":[{"given":"Yan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Guangzhou Red Cross Hospital, the Affiliated Hospital, Jinan University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjiao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Shenzhen People\u2019s Hospital, Second Clinical Medical College of Jinan University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinglan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Shenzhen People\u2019s Hospital, Second Clinical Medical College of Jinan University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"bibr1-THC-241035","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100791"},{"key":"bibr2-THC-241035","author":"Bondick CP","year":"2024","journal-title":"StatPearls. 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