{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:01:46Z","timestamp":1780066906342,"version":"3.54.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Technology and Health Care"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of the Kidney-Tonifying and Blood-Activating Formula on combating the downregulation of integrin [Formula: see text]3 and integrin [Formula: see text]5 in mouse placental tissue induced by phospholipid antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of kidney-tonifying and blood-activating formulations on combating the downregulation of integrin [Formula: see text]3 and integrin [Formula: see text]5 in mouse placental tissue induced by phospholipid antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Mice in the phospholipid antibody group and phospholipid antibody [Formula: see text] kidney-tonifying and blood-activating formula group underwent repeated implantation experiments, and the expression of integrin [Formula: see text]3 and integrin [Formula: see text]5 in placental tissue was observed. The effects of the kidney-tonifying and blood-activating formula on mouse placental tissue were evaluated through biochemical index tests, histopathological observations, and immunohistochemical staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>After intervention with the kidney-tonifying and blood-activating formula, the expression of integrin [Formula: see text]3 and integrin [Formula: see text]5 in placental tissue was notably upregulated, and placental structure was restored. Kidney-Tonifying and Blood-Activating Formula significantly improved abnormal biochemical indices and exerted a remarkable protective effect on placental tissue pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The kidney-tonifying and blood-activating formula effectively counteracted the downregulation of integrin [Formula: see text]3 and integrin [Formula: see text]5 in mouse placental tissue induced by phospholipid antibodies and alleviated placental tissue pathology through structural improvement and protection. Therefore, kidney-tonifying and blood-activating formulas may serve as potential therapeutic agents for recurrent implantation failure, offering new insights and approaches for clinical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/thc-241179","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T11:49:59Z","timestamp":1725364199000},"page":"495-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Bushen Huoxue on integrin \u03b23 and integrin \u03b25 in the placental tissue of mice with repeated implantation failure caused by phospholipid antibodies"],"prefix":"10.1177","volume":"33","author":[{"given":"Yongmei","family":"Han","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China"},{"name":"The First Clinical Medical College 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