{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:16:38Z","timestamp":1777889798869,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumour Biol."],"published-print":{"date-parts":[[2021,4,27]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Single nucleotide variants (SNVs) in vascular endothelial growth factor A ( VEGFA) and VEGFA receptor ( KDR) genes confer different inherited abilities in angiogenesis (AG) pathway. We aimed in the present study to evaluate influence of six VEGFA and four KDR SNVs in clinical features and survival of diffuse large B-cell lymphoma (DLBCL) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>One hundred and sixty-eight DLBCL patients diagnosed between June 2009-September 2014 were enrolled in the study. Patients were homogeneously treated with R-CHOP. Genotypes were identified in genomic DNA by real-time polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Patients with VEGFA -634CC and +936CT or TT genotypes were at increased risk of showing grade III \/ IV toxicities and not achieving complete remission with treatment, and shorter event-free and overall survival were seen in patients with VEGFA -1154GA or AA genotype and VEGFA ATAGCC haplotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Our data suggest that inherited abnormalities in AG\u2019s gene modulate clinical features and prognosis of DLBCL patients homogeneously treated with R-CHOP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/tub-211510","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T06:01:31Z","timestamp":1625032891000},"page":"129-140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Angiogenesis\u2019 related genetic variants alter clinical features and prognosis of diffuse large B-cell lymphoma patients"],"prefix":"10.1177","volume":"43","author":[{"given":"Angelo Borsarelli Carvalho","family":"Brito","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Torresan","family":"Delamain","sequence":"additional","affiliation":[{"name":"Haematology and Haemotherapy Centre, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello Ferreti","family":"Fanelli","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Centre, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Centre, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1rmino Ant\u00f4nio","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"},{"name":"Haematology and Haemotherapy Centre, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Vassallo","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Centre, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Molecular and Investigative Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Silvia Passos","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1593\/neo.121962"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911423031"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1159\/000054076"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V131260"},{"issue":"2","key":"ref005","first-page":"131","volume":"23","author":"Kim Y.S.","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"ref006","first-page":"812","volume":"63","author":"Stevens A.","year":"2003","journal-title":"Cancer Res"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.074"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-144"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02168.x"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1300893"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13526"},{"key":"ref012","unstructured":"SwerdlowS.H., CampoE., HarrisN.L., WHO classification of tumours of haematopoietic and lymphoid tissues. 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