{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:17:24Z","timestamp":1777889844745,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumour Biol."],"published-print":{"date-parts":[[2021,4,27]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>This study focuses on the potential presence of herpes-, polyoma- and parvoviruses in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA) and carcinoma ex pleomorphic adenoma (CaxPA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Thirty different viruses were analyzed by PCR-based assays in 68 formalin-fixed paraffin-embedded salivary gland tumors (25 PA, 31 RPA and 12 CaxPA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Virus DNA was detected altogether in 19\/68 (28%) tumor samples. Human herpesviruses 6B and 7 (HHV-6B and HHV-7) and Epstein-Barr virus (EBV) were frequently and almost exclusively found in CaxPA (5\/12, 7\/12, and 3\/12, respectively). Within the 7 CaxPA that were virus-positive, 3 samples contained 3, and 1 sample even 4, different viruses. Infrequent viral positivity was shown for parvovirus B19 and cutavirus, as well as Merkel cell and Malawi polyomaviruses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our unexpected finding of herpesvirus DNA almost exclusively in CaxPA tissues deserves further in-depth studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/tub-211519","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:27:26Z","timestamp":1633134446000},"page":"249-259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-039X","authenticated-orcid":false,"given":"Maria K.","family":"Jauhiainen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"},{"name":"Department of Virology, University of Helsinki, Helsinki, Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lari","family":"Py\u00f6ri\u00e4","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Atula","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katri","family":"Aro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anttoni","family":"Markkanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Helsinki and Turku, Helsinki and Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caj","family":"Haglund","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Helsinki and Turku, Helsinki and Turku, Finland"},{"name":"Translational Cancer Medicine, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland"},{"name":"Department of Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Helsinki and Turku, Helsinki and Turku, Finland"},{"name":"Translational Cancer Medicine, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland"},{"name":"Department of Oral Pathology and Radiology, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"S\u00f6derlund-Venermo","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saku T.","family":"Sinkkonen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"ref001","unstructured":"ValstarMH, de RidderM, van den BroekEC, StuiverMM, van DijkBAC, van VelthuysenMLF, BalmAJM, SmeeleLE. 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