{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:17:23Z","timestamp":1777889843696,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumour Biol."],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cancer progression is associated with significant systemic clinical manifestations including cachexia induced weight loss and anorexia. Pentoxifylline (PTX) is a drug that has been shown to have multiple beneficial effects in cancer patients through its anti-inflammatory properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN OBJECTIVE:<\/jats:title>\n                    <jats:p>To evaluate PTX effects on colon cancer patients treated with chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS and METHODS:<\/jats:title>\n                    <jats:p>Forty metastatic colon cancer patients receiving chemotherapy were enrolled in this randomized study. 17 patients were treated with a full dose of PTX (400\u200amg TID), 9 patients with a reduced dose PTX (200\u200amg TID) and 23 served as controls (no PTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Follow-up evaluations of patients included the following: physical examination; leukopenia determination; weight determination; stomatitis determination; and survival rate. Patients treated with PTX (both full and reduced doses), experienced a significant increase in weight and a reduction in stomatitis relative to the control group. Treatment with PTX also significantly increased patient survival rate. All patients treated with PTX, had a median overall survival (OS) rate of 20.4 months as compared to 13.2 months in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>PTX treatment of colon cancer patients, in addition to chemotherapy, significantly improved survival rates, induced weight gain and reduced stomatitis occurrence \u2013all important parameters of cachexia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/tub-211533","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T13:10:44Z","timestamp":1640092244000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of pentoxifylline on colon cancer patients treated with chemotherapy (Part I)"],"prefix":"10.1177","volume":"43","author":[{"given":"Amichay","family":"Meirovitz","sequence":"first","affiliation":[{"name":"Department of Oncology, Hadassah Medical Center and Faculty of Medicine Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Baider","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hadassah Medical Center and Faculty of Medicine Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Peretz","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hadassah Medical Center and Faculty of Medicine Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Stephanos","sequence":"additional","affiliation":[{"name":"Psychosomatic Department, Ulm University Medical Center, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Barak","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hadassah Medical Center and Faculty of Medicine Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1075.73644"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.6"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2011.0385"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr579"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13010369"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.01.002"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-019-1334-5"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.2174\/1389201019666180528084641"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.2174\/1389557517666171002162258"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.06.019"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.179182"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12943"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1038\/nrc927"},{"key":"ref014","first-page":"3661","volume":"22","author":"Persson C","year":"2002","journal-title":"Anticancer Res"},{"key":"ref015","unstructured":"MeirovitzA, BaiderL, PeretzT, StephanosS and Barak V. PTX treatment of Colon Cancer (Part II) - Mode of action and effects on Tumor Markers and Cytokines. (to be published shortly, 2021)."},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200811180232"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev-202007-21921"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1669-x"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.11.032"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.03.005"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13363"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/TUB-211533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/TUB-211533","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/TUB-211533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:21:35Z","timestamp":1777612895000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/TUB-211533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,8,30]]}},"alternative-id":["10.3233\/TUB-211533"],"URL":"https:\/\/doi.org\/10.3233\/tub-211533","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]}}}