{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:55:25Z","timestamp":1792698925661,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumour Biol."],"published-print":{"date-parts":[[2023,11,13]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>A 100-bp insertion\/deletion polymorphism in the pepsinogen C gene has been associated with the risk of gastric cancer (GC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>We analyzed the relationships of the 100-bp insertion\/deletion polymorphism with GC, atrophic gastritis (AG), and intestinal metaplasia (IM) in the Mexican general population (MGP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We studied the genomic DNA of subjects with GC n\u200a=\u200a80, AG and IM n\u200a=\u200a60, controls n\u200a=\u200a110, and the MGP n\u200a=\u200a97. PGC gene insertion\/deletion polymorphism was identified by means of PCR, capillary electrophoresis and GeneScan software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Different allele sizes of PGC polymorphism were observed in the studied groups, from 266 bp to 499 bp, which were grouped for the analysis as short alleles of 266\u2013399 bp, medium alleles of 400\u2013433 bp and large alleles of 434\u2013499 bp. Carriers of one or two medium alleles, had an increased risk of GC, with OR of 1.99 (CI95% 1.08\u20133.67 p\u200a=\u200a0.026) compared to homozygotes (no medium\/no medium).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Previous studies have related PGC short alleles to risk for or protection against GC depending on the ethnic origin of the population. In our study, medium alleles were related to risk for GC. Further studies are required to establish the importance of this polymorphism in the origin of gastric neoplasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/tub-220025","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T11:45:32Z","timestamp":1680867932000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Medium and large alleles of the\n                    <i>PGC<\/i>\n                    gene are risk factors for gastric cancer"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-6225","authenticated-orcid":false,"given":"Josefina Yoaly","family":"S\u00e1nchez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Division of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia Carolina","family":"V\u00e1zquez-Ibarra","sequence":"additional","affiliation":[{"name":"Division of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico"},{"name":"Doctoral Program in Human Genetics, Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Marlene","family":"Garc\u00eda-Muro","sequence":"additional","affiliation":[{"name":"Division of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico"},{"name":"Doctoral Program in Human Genetics, Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azaria","family":"Garc\u00eda-Ruvalcaba","sequence":"additional","affiliation":[{"name":"Division of Genetics, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico"},{"name":"Doctoral Program in Human Genetics, Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Pacheco-Sotelo","sequence":"additional","affiliation":[{"name":"Pediatric Hospital, National Medical Center of the West, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Carlos","family":"D\u00edaz-Herrera","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, National Medical Center of the West, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u0131a Eugenia","family":"Marin-Contreras","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, National Medical Center of the West, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"ref001","unstructured":"Gene [homepage on the Internet]. 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