{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:10:05Z","timestamp":1790363405394,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:p>Vestibular neuritis is a neuroinflammatory, peripheral vestibular pathology leading to chronic deficits and long-term disability. While current corticosteroid-based therapy does not appear to positively influence the long term outcome for the patient, a recent clinical pilot study suggested a functional vestibuloprotective effect of the anti-emetic ondansetron in the treatment of vestibular neuritis. We here demonstrate that systemic post-insult administration of ondansetron in a novel rat model of severe excitotoxic vestibular insult reproduces the clinically demonstrated functional benefits. This ondansetron-conferred reduction of functional deficits stems from the protection of synapses between sensory hair cells and primary neurons from excitotoxically induced lesion.<\/jats:p>","DOI":"10.3233\/ves-130483","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T18:02:55Z","timestamp":1575309775000},"page":"177-186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Ondansetron reduces lasting vestibular deficits in a model of severe peripheral excitotoxic injury"],"prefix":"10.1177","volume":"23","author":[{"given":"Jonas","family":"Dyhrfjeld-Johnsen","sequence":"first","affiliation":[{"name":"Sensorion, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gaboyard-Niay","sequence":"additional","affiliation":[{"name":"Sensorion, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Broussy","sequence":"additional","affiliation":[{"name":"Sensorion, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Saleur","sequence":"additional","affiliation":[{"name":"Sensorion, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Brugeaud","sequence":"additional","affiliation":[{"name":"Sensorion, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Chabbert","sequence":"additional","affiliation":[{"name":"Sensorion, Montpellier, France"},{"name":"INSERM U1051, Institute for Neurosciences Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,9,1]]},"container-title":["Journal of Vestibular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/VES-130483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/VES-130483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:21:59Z","timestamp":1777612919000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/VES-130483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9,1]]}},"alternative-id":["10.3233\/VES-130483"],"URL":"https:\/\/doi.org\/10.3233\/ves-130483","relation":{},"ISSN":["0957-4271","1878-6464"],"issn-type":[{"value":"0957-4271","type":"print"},{"value":"1878-6464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,1]]}}}