{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:17:03Z","timestamp":1777889823596,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>M\u00e9ni\u00e8re's disease (MD) is defined as\nan idiopathic disorder of the inner ear characterized by the triad of\ntinnitus, vertigo, and sensorineural hearing loss. Although many studies\nhave evaluated the association between variants in the KCNE1 or KCNE3 gene\nand MD risk, debates still exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Our aim is to evaluate the association between KCNE gene\nvariants, including KCNE1 rs1805127 and KCNE3 rs2270676, and the risk of MD\nby a systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We searched the literature in PubMed, SCOPUS and\nEMBASE through May 2015. We calculated pooled odds ratios (OR) and 95%\nconfidence intervals (CIs) using a fixed-effects model or a random-effects\nmodel for the risk to MD associated with different KCNE gene variants. The\nheterogeneity assumption decided the effect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of three relevant studies, with 302 MD\ncases and 515 controls, were included in this meta-analysis. The results\nindicated that neither the KCNE1 rs1805127 variant (for G vs. A: OR = 0.724,\n95%CI 0.320, 1.638, P= 0.438), nor the KCNE3 rs2270676 variant (for T vs.\nC: OR = 0.714, 95%CI 0.327, 1.559, P = 0.398) was associated with MD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Based on current evidence from published\nstudies, neither of the two variants from KCNE was significantly associated\nwith the risk of MD. Larger studies with mixed ethnicity subjects and\nstratified by clinical and sub-clinical characteristics are needed to\nvalidate our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/ves-160569","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T07:30:25Z","timestamp":1454916625000},"page":"211-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Variants in the KCNE1 or KCNE3 gene and risk of M\u00e9ni\u00e8re's disease: A meta-analysis"],"prefix":"10.1177","volume":"25","author":[{"given":"Yuan-Jun","family":"Li","sequence":"first","affiliation":[{"name":"The Center of Clinical Aviation Medicine, General Hospital of Air Force, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan-Guo","family":"Jin","sequence":"additional","affiliation":[{"name":"The Center of Clinical Aviation Medicine, General Hospital of Air Force, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Rong","family":"Xu","sequence":"additional","affiliation":[{"name":"The Center of Clinical Aviation Medicine, General Hospital of Air Force, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"181","volume-title":"Otolaryngol Head Neck Surg","year":"1995","unstructured":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease. 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