{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:10:07Z","timestamp":1790363407931,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"2-3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VES"],"published-print":{"date-parts":[[2017,6,6]]},"DOI":"10.3233\/ves-170612","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T11:49:28Z","timestamp":1496749768000},"page":"89-101","source":"Crossref","is-referenced-by-count":21,"title":["Ethovision\u2122 analysis of open field behaviour in rats following bilateral vestibular loss"],"prefix":"10.1177","volume":"27","author":[{"given":"Phillip","family":"Aitken","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Biomedical Sciences, and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Biomedical Sciences, and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand"},{"name":"Brain Research New Zealand Centre of Research Excellence for Hearing and Balance Research, University of Auckland, New Zealand"},{"name":"The Eisdell Moore Centre for Hearing and Balance Research, University of Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Biomedical Sciences, and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand"},{"name":"Brain Research New Zealand Centre of Research Excellence for Hearing and Balance Research, University of Auckland, New Zealand"},{"name":"The Eisdell Moore Centre for Hearing and Balance Research, University of Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/VES-170612_ref1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/hipo.22651","article-title":"Hippocampal and striatal M1-muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats","volume":"26","author":"Aitken","year":"2016","journal-title":"Hippocampus"},{"key":"10.3233\/VES-170612_ref2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.nlm.2010.08.007","article-title":"Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent","volume":"94","author":"Baek","year":"2010","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.3233\/VES-170612_ref3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3940(99)00050-6","article-title":"Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats","volume":"265","author":"Basile","year":"1999","journal-title":"Neuroscience Letters"},{"key":"10.3233\/VES-170612_ref4","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/hipo.20942","article-title":"Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors","volume":"22","author":"Besnard","year":"2012","journal-title":"Hippocampus"},{"key":"10.3233\/VES-170612_ref5","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/toxsci\/kfi314","article-title":"Behavioral and pathological effects in the rat define two groups of neurotoxic nitriles","volume":"88","author":"Boadas-Vaello","year":"2005","journal-title":"Toxicological Sciences"},{"key":"10.3233\/VES-170612_ref6","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awh617","article-title":"Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans","volume":"128","author":"Brandt","year":"2005","journal-title":"Brain"},{"key":"10.3233\/VES-170612_ref7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF02246178","article-title":"Evidence for genetically mediated dysfunction of the central dopaminergic system in the stargazer rat","volume":"123","author":"Brock","year":"1996","journal-title":"Psychopharmacology (Berl)"},{"key":"10.3233\/VES-170612_ref8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0306-4522(96)00358-2","article-title":"Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus","volume":"76","author":"Chapman","year":"1996","journal-title":"Neuroscience"},{"key":"10.3233\/VES-170612_ref9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0166-2236(94)90005-1","article-title":"Modulatory functions of neurotransmitters in the striatum: ACh\/dopamine\/NMDA interactions","volume":"17","author":"Di Chiara","year":"1994","journal-title":"Trends in Neurosciences"},{"key":"10.3233\/VES-170612_ref10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0006-8993(96)00692-0","article-title":"DA1 and DA2 receptor regulation in the striatum of young and old rats after peripheral vestibular lesion","volume":"736","author":"Giardino","year":"1996","journal-title":"Brain Research"},{"key":"10.3233\/VES-170612_ref11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1037\/0735-7044.122.2.448","article-title":"Locomotor and exploratory behavior in the rat following bilateral vestibular deafferentation","volume":"122","author":"Goddard","year":"2008","journal-title":"Behavioral Neuroscience"},{"key":"10.3233\/VES-170612_ref12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0149-7634(83)90014-3","article-title":"Comparison between the behavioural effects of septal and hippocampal lesions: A review","volume":"7","author":"Gray","year":"1983","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.3233\/VES-170612_ref13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(84)90653-X","article-title":"Differentiation of basal ganglia dopaminergic involvement in behavior after hippocampectomy","volume":"291","author":"Hannigan","year":"1984","journal-title":"Brain Research"},{"key":"10.3233\/VES-170612_ref14","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-84858-7","volume-title":"The elements of statistical learning: Data Mining, Inference, and Prediction","author":"Hastie","year":"2009"},{"issue":"5","key":"10.3233\/VES-170612_ref15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ana.20290","article-title":"Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan","volume":"56","author":"Ishii","year":"2004","journal-title":"Annals of Neurology"},{"key":"10.3233\/VES-170612_ref16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1046\/j.0953-816x.2001.01726.x","article-title":"Auditory and vestibular defects in the circling (ci2) rat mutant","volume":"14","author":"Kaiser","year":"2001","journal-title":"European Journal of Neuroscience"},{"key":"10.3233\/VES-170612_ref17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.289.5479.633","article-title":"Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function","volume":"289","author":"Kaneko","year":"2000","journal-title":"Science"},{"key":"10.3233\/VES-170612_ref18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuroscience.2004.05.052","article-title":"Abnormal motor behavior and vestibular dysfunction in the stargazer mouse mutant","volume":"127","author":"Khan","year":"2004","journal-title":"Neuroscience"},{"key":"10.3233\/VES-170612_ref19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0306-4522(96)00248-5","article-title":"Behavioural and neurochemical dysfunction in the circling (ci) rat: A novel genetic animal model of a movement disorder","volume":"74","author":"L\u00f6scher","year":"1996","journal-title":"Neuroscience"},{"key":"10.3233\/VES-170612_ref20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/hipo.22251","article-title":"Vestibular loss promotes procedural response during a spatial task in rats","volume":"24","author":"Machado","year":"2014","journal-title":"Hippocampus"},{"key":"10.3233\/VES-170612_ref21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuroscience.2012.05.029","article-title":"Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat","volume":"218","author":"Machado","year":"2012","journal-title":"Neuroscience"},{"key":"10.3233\/VES-170612_ref22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/00016480260092282","article-title":"Three-dimensional analysis of human locomotion in normal subjects and patients with vestibular deficiency","volume":"122","author":"Mamoto","year":"2002","journal-title":"Acta Oto-laryngologica"},{"key":"10.3233\/VES-170612_ref23","volume-title":"Multivariate statistical methods: A primer","author":"Manly","year":"2005"},{"key":"10.3233\/VES-170612_ref24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-8993(97)00928-1","article-title":"Locomotion and stereotypy induced by scopolamine: Contributions of muscarinic receptors near the pedunculopontine tegmental nucleus","volume":"775","author":"Mathur","year":"1997","journal-title":"Brain Research"},{"key":"10.3233\/VES-170612_ref25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1525-1403.2009.00214.x","article-title":"The deep brain stimulation of the pedunculopontine tegmental nucleus","volume":"12","author":"Mazzone","year":"2009","journal-title":"Neuromodulation"},{"key":"10.3233\/VES-170612_ref26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fneur.2011.00088","article-title":"Compensation following bilateral vestibular damage","volume":"2","author":"McCall","year":"2011","journal-title":"Frontiers in Neurology"},{"key":"10.3233\/VES-170612_ref27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0166-4328(05)80248-7","article-title":"Sodium arsanilate-induced vestibular dysfunction in meadow voles (Microtus pennsylvanicus): Effects on posture, spontaneous locomotor activity and swimming behavior","volume":"47","author":"Ossenkopp","year":"1992","journal-title":"Behavioural Brain Research"},{"key":"10.3233\/VES-170612_ref28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fnins.2016.00355","article-title":"Evidence for a role of orexin\/hypocretin system in vestibular lesion-induced locomotor abnormalities in rats","volume":"10","author":"Pan","year":"2016","journal-title":"Frontiers in Neuroscience"},{"key":"10.3233\/VES-170612_ref29","first-page":"159","article-title":"Vestibular compensation is affected by treatment with dopamine active agents","volume":"131","author":"Petrosini","year":"1993","journal-title":"Archives Italiennes de Biologie"},{"issue":"5","key":"10.3233\/VES-170612_ref30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1539\/joh.47.445","article-title":"Oxidative dna damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmentally relevant levels","volume":"47","author":"Piao","year":"2005","journal-title":"Journal of Occupational Health"},{"key":"10.3233\/VES-170612_ref31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0031-9384(90)90255-3","article-title":"An open-field activity analysis of labyrinthectomized rats","volume":"48","author":"Porter","year":"1990","journal-title":"Physiology & Behavior"},{"key":"10.3233\/VES-170612_ref32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbr.2006.09.015","article-title":"Central nicotinic cholinergic systems: A role in the cognitive dysfunction in attention-deficit\/hyperactivity disorder?","volume":"175","author":"Potter","year":"2006","journal-title":"Behavioural Brain Research"},{"key":"10.3233\/VES-170612_ref33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s002210000568","article-title":"Abnormal vestibular control of gaze and posture in a strain of a waltzing rat","volume":"136","author":"Rabbath","year":"2001","journal-title":"Experimental Brain Research"},{"key":"10.3233\/VES-170612_ref34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s004150050225","article-title":"Bilateral loss of vestibular function: Clinical findings in 53 patients","volume":"245","author":"Rinne","year":"1998","journal-title":"Journal of Neurology"},{"key":"10.3233\/VES-170612_ref35","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1152\/jn.1998.80.5.2352","article-title":"Neuronal activity in the vestibular nuclei after contralateral or bilateral labyrinthectomy in the alert guinea pig","volume":"80","author":"Ris","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.3233\/VES-170612_ref36","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1523\/JNEUROSCI.23-16-06490.2003","article-title":"Long-term effects of permanent vestibular lesions on hippocampal spatial firing","volume":"23","author":"Russell","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.3233\/VES-170612_ref37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainres.2007.04.012","article-title":"Auditory and vestibular defects and behavioral alterations after neonatal administration of streptomycin to Lewis rats: Similarities and differences to the circling (ci2\/ci2) Lewis rat mutant","volume":"1155","author":"Schirmer","year":"2007","journal-title":"Brain Research"},{"key":"10.3233\/VES-170612_ref38","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbr.2007.03.013","article-title":"Marked differences in response to dopamine receptor antagonism in two rat mutants, ci2 and ci3, with lateralized rotational behavior","volume":"180","author":"Schirmer","year":"2007","journal-title":"Behavioural Brain Research"},{"key":"10.3233\/VES-170612_ref39","first-page":"13","article-title":"Alteration of high-affinity binding sites of neurotransmitter receptors in rats after neonatal exposure to streptomycin","volume":"3","author":"Seth","year":"1982","journal-title":"Neurotoxicology"},{"key":"10.3233\/VES-170612_ref40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0165-0173(89)90013-1","article-title":"Mechanisms of recovery following unilateral labyrinthectomy: A review","volume":"14","author":"Smith","year":"1989","journal-title":"Brain Res Brain Res Rev"},{"key":"10.3233\/VES-170612_ref41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbr.2013.02.033","article-title":"A multivariate statistical and data mining analysis of spatial memory-related behaviour following bilateral vestibular loss in the rat","volume":"246","author":"Smith","year":"2013","journal-title":"Behavioural Brain Research"},{"key":"10.3233\/VES-170612_ref42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/B978-0-444-63437-5.00024-8","article-title":"Functional and Psychiatric Vestibular Disorders","volume":"137","author":"Staab","year":"2016","journal-title":"Handbook of Clinical Neurology"},{"key":"10.3233\/VES-170612_ref43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hipo.1112","article-title":"Hippocampal spatial representations require vestibular input","volume":"12","author":"Stackman","year":"2002","journal-title":"Hippocampus"},{"key":"10.3233\/VES-170612_ref44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.brainres.2014.11.063","article-title":"The vestibular-basal ganglia connection: Balancing motor control","volume":"1597","author":"Stiles","year":"2015","journal-title":"Brain Research"},{"key":"10.3233\/VES-170612_ref45","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbr.2011.11.006","article-title":"The D(2) dopamine receptor and locomotor hyperactivity following bilateral vestibular deafferentation in the rat","volume":"227","author":"Stiles","year":"2012","journal-title":"Behavioural Brain Research"},{"key":"10.3233\/VES-170612_ref46","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1471-244X-12-190","article-title":"Hyperactivity persists in male and female adults with ADHD and remains a highly discriminative feature of the disorder: A case-control study","volume":"12","author":"Teicher","year":"2012","journal-title":"BMC Psychiatry"},{"key":"10.3233\/VES-170612_ref47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1113\/jphysiol.2004.063883","article-title":"Postural and locomotor control in normal and vestibularly deficient mice","volume":"559","author":"Vidal","year":"2004","journal-title":"J Physiol"},{"key":"10.3233\/VES-170612_ref48","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.taap.2011.10.008","article-title":"Evaluation of the chemical model of vestibular lesions induced by arsanilate in rats","volume":"258","author":"Vignaux","year":"2012","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.3233\/VES-170612_ref49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.brainresbull.2006.09.019","article-title":"Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains","volume":"71","author":"Yang","year":"2006","journal-title":"Brain Research Bulletin"},{"key":"10.3233\/VES-170612_ref50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbr.2012.07.025","article-title":"Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs","volume":"235","author":"Zheng","year":"2012","journal-title":"Behavioural Brain Research"}],"container-title":["Journal of Vestibular Research"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/VES-170612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:22:31Z","timestamp":1777612951000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/VES-170612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,6]]},"references-count":50,"journal-issue":{"issue":"2-3"},"URL":"https:\/\/doi.org\/10.3233\/ves-170612","relation":{},"ISSN":["0957-4271","1878-6464"],"issn-type":[{"value":"0957-4271","type":"print"},{"value":"1878-6464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,6]]}}}