{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:50:11Z","timestamp":1790214611374,"version":"4.1.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"2-3","license":[{"start":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T00:00:00Z","timestamp":1545609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"published-print":{"date-parts":[[2019,7,25]]},"abstract":"<jats:p>The diagnostic criteria for Meniere Disease (MD) are clinical and include two categories: definite MD and probable MD, based on clinical examination and without the necessity of advanced vestibular or audiological testing. The condition is a heterogeneous disorder and it is associated with endolymphatic hydrops (EH), an accumulation of endolymph in the inner ear that causes damage to the ganglion cells. Patients with suspected EH can be examined by Magnetic Resonance Imaging (MRI), offering new insights into these inner ear disorders. Results of imaging studies using the hydrops protocols show conflicting results in MD patients. These discrepancies can be dependent either on the MRI sequence parameters or on the method of hydrops grading or the inclusion criteria to select patients. The visualization of EH can be classified based on a semi-quantitative ratio between endolymph and perilymph liquids, or on the distinction between the saccule and the utricle structures. In addition, MRI can also be used to evaluate whether cochleovestibular nerves can present with imaging signs of axonal loss.<\/jats:p>\n                  <jats:p>In this systematic review, we have selected case-controlled studies to better characterize the potential added value in the diagnosis and management of patients with MD. Using different techniques, studies have identified the saccule as the most specifically involved structure in MD, and saccular hydrops seems to be associated with low to medium-tone sensorineural hearing loss degree. However, early symptoms still appear too subtle for identification using MRI and the reproducibility of the hydrops protocols with various MRI scan manufacturers is debatable, thus limiting expansion of these techniques into clinical practice for the diagnosis of MD at this time.<\/jats:p>\n                  <jats:p>Further research is needed. The future inclusion of semicircular canal hydrops location in the imaging signs and the application of MRI in patients with atypical presentations hold promise.<\/jats:p>","DOI":"10.3233\/ves-180646","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T13:04:04Z","timestamp":1545656644000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Systematic review of magnetic resonance imaging for diagnosis of Meniere disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Jose A.","family":"Lopez-Escamez","sequence":"first","affiliation":[{"name":"Otology and Neurotology Group CTS495, Department of Genomic Medicine- Centro de Gen\u00f3mica e Investigaci\u00f3n Oncol\u00f3gica \u2013 Pfizer\/Universidad de Granada\/Junta de Andaluc\u00eda (Genyo), PTS, Granada, Spain"},{"name":"Department of Otolaryngology, Instituto de Investigaci\u00f3n Biosanitaria, 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