{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:57:56Z","timestamp":1789844276338,"version":"4.0.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VES"],"published-print":{"date-parts":[[2021,7,28]]},"abstract":"<jats:p>This paper provides a new hypothetical explanation for the etiopathology and pathophysiology of Meni\u00e8re\u2019s Disease (MD), which to date remain unexplained, or incompletely understood. The suggested hypothesis will explain the close connection of MD and Migraine, the coexistence of endolymphatic hydrops (ELH) and Meni\u00e8re attacks and the signs of inflammation detected in the inner ears of MD patients. Although as yet unproven, the explanations provided appear highly plausible and could pave the way for the generation of the first animal model of MD \u2013 an invaluable asset for developing new treatment strategies. Furthermore, if proven correct, this hypothesis could redefine and also reset the actual name of Meni\u00e8re\u2019s Syndrome to Meni\u00e8re\u2019s Disease.<\/jats:p>","DOI":"10.3233\/ves-200716","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T13:16:26Z","timestamp":1601990186000},"page":"311-314","source":"Crossref","is-referenced-by-count":15,"title":["Meni\u00e8re\u2019s disease caused by CGRP - A new hypothesis explaining etiology and pathophysiology. Redirecting Meni\u00e8re\u2019s syndrome to Meni\u00e8re\u2019s disease"],"prefix":"10.1177","volume":"31","author":[{"given":"Stefan Carl Anton","family":"Hegemann","sequence":"first","affiliation":[{"name":"Balance-Clinic, Nueschelerstrasse, Zurich, Switzerland"},{"name":"Zurich University, Faculty of Medicine, R\u00e4mistrasse, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/VES-200716_ref1","doi-asserted-by":"crossref","unstructured":"AAO-HNS, Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere\u2019s disease, Otolaryngol Head Neck Surg 113(3) (1995), 181\u2013186.","DOI":"10.1016\/S0194-5998(95)70102-8"},{"issue":"1","key":"10.3233\/VES-200716_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meniere\u2019s disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J Vestib Res"},{"issue":"6","key":"10.3233\/VES-200716_ref3","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3109\/00016480903382808","article-title":"Long-term course of Meniere\u2019s disease revisited","volume":"130","author":"Huppert","year":"2010","journal-title":"Acta Otolaryngol"},{"issue":"7","key":"10.3233\/VES-200716_ref4","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/MAO.0b013e31829e83df","article-title":"Endolymphatic hydrops in Meniere\u2019s disease: cause, consequence, or epiphenomenon?","volume":"34","author":"Foster","year":"2013","journal-title":"Otol Neurotol"},{"issue":"3","key":"10.3233\/VES-200716_ref5","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/000348946707600311","article-title":"Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig. 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