{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:19:41Z","timestamp":1777889981668,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VES"],"published-print":{"date-parts":[[2021,10,4]]},"abstract":"<jats:p>The aim of the present study was to evaluate the severity of vestibular drop attack (VDA) in M\u00e9ni\u00e8re\u2019s disease (MD) and to examine the association between VDA severity and other MD-related complaints. The study used a cross-sectional survey design using an electronic questionnaire. The mean age of participants was 56.7 years, and the mean duration of MD was 12.4 years. Four categories of VDA were identified based on level of severity. VDA occurred in 305 (50.7%) of the 602 patients. Of these, 133 patients (22%) experienced mild VDA (i.e., associated with tripping); 80 (13%) experienced moderate VDA (i.e., associated with fall threat unless they had been able to grab support); and 92 (15%) experienced severe VDA (i.e., patients fell to the ground, as in a classical Tumarkin attack). In 70%of participants, VDA occurred less than once a week. VDA lasted for only a few seconds in 90%of participants. 87%reported single attacks, whereas 13%experienced VDA in clusters. VDA was associated with visual auras, reduced quality of life, poor postural control, and fatigue. Approximately half of MD patients experience VDA with varying degrees of severity. If VDA causes falls or near-falls, the attacks should be appropriately treated.<\/jats:p>","DOI":"10.3233\/ves-201502","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T12:37:52Z","timestamp":1614343072000},"page":"389-399","source":"Crossref","is-referenced-by-count":7,"title":["Vestibular drop attacks in M\u00e9ni\u00e8re\u2019s disease"],"prefix":"10.1177","volume":"31","author":[{"given":"Ilmari","family":"Pyykk\u00f6","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Hearing and Balance Research Unit, University of Tampere, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Pyykk\u00f6","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Tartu, Tartu, Estonia"},{"name":"Finnish M\u00e9ni\u00e8re Federation, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinaya","family":"Manchaiah","sequence":"additional","affiliation":[{"name":"Department of Speech and Hearing Sciences, Lamar University, Beaumont, TX, USA"},{"name":"Department of Speech and Hearing, School of Allied Health Sciences, Manipal University, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"7","key":"10.3233\/VES-201502_ref1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1097\/MAO.0b013e31826426b9","article-title":"Characteristics of patients with unilateral and bilateral Meniere\u2019s disease","volume":"33","author":"Clemmens","year":"2012","journal-title":"Otol Neurotol"},{"issue":"1","key":"10.3233\/VES-201502_ref2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/AUD.0000000000000748","article-title":"Psychometric properties of cognitive-motor dual-task studies with the aim of developing a test protocol for persons with vestibular disorders: A systematic review","volume":"41","author":"Danneels","year":"2020","journal-title":"Ear Hear"},{"key":"10.3233\/VES-201502_ref3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/B978-0-444-63622-5.00006-1","article-title":"The parietal lobe and the vestibular system","volume":"151","author":"Dieterich","year":"2018","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"10.3233\/VES-201502_ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00405-018-5157-3","article-title":"Clinical manifestations of hydropic ear disease (Meni\u00e8re\u2019s)","volume":"276","author":"G\u00fcrkov","year":"2018","journal-title":"Eur Arch Otothinolaryngol"},{"issue":"1","key":"10.3233\/VES-201502_ref5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00221-013-3637-7","article-title":"Modulation of muscle sympathetic nerve activity by low-frequency physiological activation of the vestibular utricle in awake humans","volume":"230","author":"Hammam","year":"2013","journal-title":"Exp Brain Res"},{"issue":"1","key":"10.3233\/VES-201502_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"The International Classification of Headache Dthe international classification of headache disorders, 3rd edition","volume":"38","author":"Headache Classification Committee of the International Headache Society, (IHS)","year":"2018","journal-title":"Cephalalgia"},{"issue":"7","key":"10.3233\/VES-201502_ref7","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/MAO.0b013e31826352e8","article-title":"Ocular and Cervical Vestibular-Evoked Myogenic Potentials in Tumarkin Falls","volume":"33","author":"Huang","year":"2012","journal-title":"Otol Neurotol"},{"key":"10.3233\/VES-201502_ref8","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3109\/00016480903382808","article-title":"Long-term course of Meniere\u2019s disease revisited","volume":"130","author":"Huppert","year":"2020","journal-title":"Acta Otolaryngol"},{"key":"10.3233\/VES-201502_ref9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/00016487509121280","article-title":"Effect of different vestibular lesions upon body equilibrium function in squirrel monkeys","volume":"330","author":"Igarashi","year":"1975","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.3233\/VES-201502_ref10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0165-1838(80)90020-X","article-title":"Sympathetic responses evoked by vestibular stimulation and their interactions with somato-sympathetic reflexes","volume":"1","author":"Ishikawa","year":"1980","journal-title":"J Auton Nerv Syst"},{"issue":"7","key":"10.3233\/VES-201502_ref11","first-page":"359","article-title":"Conservative management of Tumarkin\u2019s otolithic crisis","volume":"17","author":"Janzen","year":"1988","journal-title":"J Otolaryngol"},{"key":"10.3233\/VES-201502_ref12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1067\/mhn.2001.115169","article-title":"Short lasting drop attacks in Meniere\u2019s disease","volume":"124","author":"Kentala","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"10.3233\/VES-201502_ref13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.wco.0000199021.48538.d9","article-title":"Function tests of the otolith or statolith system","volume":"19","author":"Kingma","year":"2006","journal-title":"Curr Opin Neurol"},{"issue":"2","key":"10.3233\/VES-201502_ref14","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/MAO.0000000000000544","article-title":"Association between saccular function and gait speed: data from the Baltimore Longitudinal Study of Aging","volume":"23","author":"Layman","year":"2015","journal-title":"Otol Neurotol"},{"issue":"4","key":"10.3233\/VES-201502_ref15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/21695717.2013.835090","article-title":"Fatigue in Meniere\u2019s disorder","volume":"11","author":"Levo","year":"2013","journal-title":"Hear Balance Commun"},{"issue":"3","key":"10.3233\/VES-201502_ref16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/MRR.0b013e3283531f95","article-title":"EuroQol 5D quality of life in Meni\u00e8re\u2019s disorder can be explained with symptoms and disabilities","volume":"35","author":"Levo","year":"2012","journal-title":"Int J Rehabil Res"},{"key":"10.3233\/VES-201502_ref17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/jech.46.2.92","article-title":"The epidemiology of fatigue: more questions than answers","volume":"46","author":"Lewis","year":"1992","journal-title":"J Epidem Comm Health"},{"issue":"1","key":"10.3233\/VES-201502_ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meni\u00e8re\u2019s disease","volume":"25","author":"Lopez-Escameza","year":"2015","journal-title":"J Vestib Res"},{"key":"10.3233\/VES-201502_ref19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0001-6519(05)78650-7","article-title":"Crisis otol\u00edticas de Tumarkin o drop attacks en pacientes con enfermedad de Meniere","volume":"56","author":"Morales Angulo","year":"2005","journal-title":"Acta Otorrinolaringol Esp"},{"key":"10.3233\/VES-201502_ref20","doi-asserted-by":"crossref","first-page":"16028","DOI":"10.1038\/nrdp.2016.28","article-title":"Meniere\u2019s disease","volume":"2","author":"Nakashima","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"10.3233\/VES-201502_ref22","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1159\/000310899","article-title":"Auditory and vestibular assessment of patients with M\u00e9ni\u00e8re\u2019s disease who suffer tumarkin attacks","volume":"15","author":"Perez-Fernandez","year":"2010","journal-title":"Audiol Neurootol"},{"issue":"9","key":"10.3233\/VES-201502_ref23","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1007\/s00405-014-3041-3","article-title":"Fatigue during an episode of benign paroxysmal positional vertigo","volume":"272","author":"Pollak","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.3233\/VES-201502_ref24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF00230002","article-title":"Head stabilization during various locomotor tasks in humans. II. Patients with bilateral peripheral vestibular deficits","volume":"85","author":"Pozzo","year":"1991","journal-title":"Exp Brain Res"},{"issue":"5","key":"10.3233\/VES-201502_ref25","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.anl.2019.02.002","article-title":"Association between M\u00e9ni\u00e8re\u2019s disease and Vestibular Migraine","volume":"46","author":"Pyykk\u00f6","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"10.3233\/VES-201502_ref26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1186\/s40064-015-1527-0","article-title":"Impact evaluation and association with EuroQol 5D health-related utility values in M\u00e9ni\u00e8re\u2019s disease","volume":"4","author":"Pyykko","year":"2015","journal-title":"SpringerPlus"},{"issue":"7","key":"10.3233\/VES-201502_ref27","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1080\/14992027.2017.1282631","article-title":"Internet-based peer support for M\u00e9ni\u00e8re\u2019s disease: a summary of web-based data collection, impact evaluation, and user evaluation","volume":"56","author":"Pyykko","year":"2017","journal-title":"Int J Audiol"},{"issue":"Suppl1","key":"10.3233\/VES-201502_ref28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s00415-017-8452-9","article-title":"Do patients with M\u00e9ni\u00e8re\u2019s disease have attacks of syncope?","volume":"264","author":"Pyykko","year":"2017","journal-title":"J Neurol"},{"issue":"2","key":"10.3233\/VES-201502_ref29","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.anl.2017.03.023","article-title":"Vestibular syncope: A disorder associated with drop attack in M\u00e9ni\u00e8re\u2019s disease","volume":"45","author":"Pyykk\u00f6","year":"2018","journal-title":"Auris Nasus Larynx"},{"issue":"3-4","key":"10.3233\/VES-201502_ref30","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3233\/VES-180634","article-title":"Impact of Tumarkin attacks on complaints and work ability in M\u00e9ni\u00e8re\u2019s disease","volume":"28","author":"Pyykk\u00f6","year":"2018","journal-title":"J Vestib Res"},{"issue":"2","key":"10.3233\/VES-201502_ref31","doi-asserted-by":"publisher","first-page":"289","DOI":"10.5152\/iao.2019.5915","article-title":"Driving habits and risk for traffic accidents among people with M\u00e9ni\u00e8re\u2019s disease in Finland","volume":"15","author":"Pyykk\u00f6","year":"2019","journal-title":"J Int Adv Otol"},{"issue":"2","key":"10.3233\/VES-201502_ref32","doi-asserted-by":"crossref","first-page":"e1555","DOI":"10.1136\/bmjopen-2012-001555","article-title":"Meniere\u2019s disease: a reappraisal supported by a variable latency of symptoms and the MRI visualisation of endolymphatic hydrops","volume":"3","author":"Pyykko","year":"2013","journal-title":"BMJ Open"},{"issue":"1","key":"10.3233\/VES-201502_ref33","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5152\/iao.2019.6094","article-title":"Association between syncope and Tumarkin attacks in M\u00e9ni\u00e8re\u2019s disease","volume":"15","author":"Pyykk\u00f6","year":"2019","journal-title":"J Int Adv Otol"},{"issue":"7","key":"10.3233\/VES-201502_ref34","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s00405-020-05890-3","article-title":"Vestibular drop attacks in M\u00e9ni\u00e8re\u2019s disease and its association with migraine","volume":"277","author":"Pyykk\u00f6","year":"2020","journal-title":"Eur Arch Otothinolaryngol"},{"issue":"3","key":"10.3233\/VES-201502_ref35","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1152\/jn.00708.2018","article-title":"Semicircular canal biomechanics in health and disease","volume":"121","author":"Rabbitt","year":"2019","journal-title":"J Neurophysiol"},{"issue":"1-2","key":"10.3233\/VES-201502_ref36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000503600","article-title":"Chronic electrical stimulation of the otolith organ: Preliminary results in humans with bilateral vestibulopathy and sensorineural hearing loss","volume":"25","author":"Ramos Macias","year":"2020","journal-title":"Audiol Neurootol"},{"key":"10.3233\/VES-201502_ref37","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fnins.2016.00096","article-title":"A model of blood pressure, heart rate, and vaso-vagal responses produced by vestibulo-sympathetic activation","volume":"10","author":"Raphan","year":"2016","journal-title":"Front Neurosci"},{"issue":"2","key":"10.3233\/VES-201502_ref38","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.2196\/rehab.4109","article-title":"Disease profiling for computerized peer support of M\u00e9ni\u00e8re\u2019s disease","volume":"2","author":"Rasku","year":"2015","journal-title":"JMIR Rehabil Assist Technol"},{"issue":"4","key":"10.3233\/VES-201502_ref39","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1097\/AUD.0000000000000825","article-title":"Cross-sectional analysis of cognitive dysfunction in patients with vestibular disorders","volume":"41","author":"Rizk","year":"2020","journal-title":"Ear Hear"},{"issue":"5","key":"10.3233\/VES-201502_ref41","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/01.mlg.0000205129.78600.27","article-title":"Vestibular evoked myogenic potential (VEMP) in patients with Meniere\u2019s disease with drop attacks","volume":"116","author":"Timmer","year":"2006","journal-title":"Laryngoscope"},{"issue":"936","key":"10.3233\/VES-201502_ref42","first-page":"175","article-title":"The otolithic catastrophe: a new syndrome","volume":"11","author":"Tumarkin","journal-title":"Br Med J"},{"issue":"3","key":"10.3233\/VES-201502_ref43","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/eurpub\/ckp113","article-title":"Fatigue and chronic fatigue syndrome-like complaints in the general population","volume":"20","author":"van\u2019t Leven","year":"2010","journal-title":"Eur J Public Health"},{"key":"10.3233\/VES-201502_ref44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.gaitpost.2008.08.002","article-title":"Gaze stabilization and gait performance in vestibular dysfunction","volume":"29","author":"Whitney","year":"2009","journal-title":"Gait Posture"},{"issue":"3","key":"10.3233\/VES-201502_ref45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00405-018-5260-5","article-title":"Clinical features and management of Meniere\u2019s disease patients with drop attacks","volume":"276","author":"Wu","year":"2019","journal-title":"Eur Arch Otothinolaryngol"},{"key":"10.3233\/VES-201502_ref46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/VES-2005-15301","article-title":"The effects of vestibular system lesions on autonomic regulation: Observations, mechanisms, and clinical implications","volume":"15","author":"Yates","year":"2005","journal-title":"J Vest Res"},{"issue":"6","key":"10.3233\/VES-201502_ref47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.21037\/atm.2016.03.13","article-title":"Migraine in the era of precision medicine","volume":"4","author":"Zhang","year":"2016","journal-title":"Ann Transl Med"}],"container-title":["Journal of Vestibular Research"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/VES-201502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:26:14Z","timestamp":1777613174000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/VES-201502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":45,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3233\/ves-201502","relation":{},"ISSN":["0957-4271","1878-6464"],"issn-type":[{"value":"0957-4271","type":"print"},{"value":"1878-6464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]}}}