{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:09:32Z","timestamp":1791580172487,"version":"4.3.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VES"],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:p>BACKGROUND: Obstructive sleep apnea (OSA) could influence peripheral vestibular function adversely via intermittent hypoxia and its consequences. OBJECTIVE: This study aimed to evaluate the risk of peripheral vestibular disorders in OSA using a nationwide population-based retrospective cohort study. METHODS: The National Health Insurance Service\u2013National Sample Cohort represents the entire Korean population from 2002 to 2015. OSA was defined as individuals who had used medical services twice or more under a diagnosis of OSA(G47.33 in ICD-10). A comparison cohort consisted of socio-demographically matched non-OSA subjects in a ratio of 1:4. The incidences of benign paroxysmal positional vertigo(BPPV), Meniere\u2019s disease, and vestibular neuritis were evaluated in each cohort. RESULTS: A total of 2,082 individuals with OSA and 8,328 matched non-OSA subjects were identified. The incidence rates(IRs) of peripheral vertigo in OSA and non-OSA were 149.86 and 23.88 per 10,000 persons, respectively (Ratio of IR, IRR\u200a=\u200a6.28, 95%CI 4.89 to 8.08). In multivariable analysis, the risk of peripheral vertigo was significantly higher in OSA(adjusted HR\u200a=\u200a6.64, 95%CI 5.20 to 8.47), old age(adjusted HR\u200a=\u200a1.03, 95%CI 1.02 to 1.04), female sex(adjusted HR\u200a=\u200a1.92, 95%CI 1.48 to 2.50), and comorbidities(adjusted HR\u200a=\u200a1.09, 95%CI 1.003 to 1.19). The IRRs of each vestibular disorder in the two groups were 7.32(95%CI 4.80 to 11.33) for BPPV, 3.61(95%CI 2.24 to 5.81) for Meniere\u2019s disease, and 9.51(95%CI 3.97 to 25.11) for vestibular neuritis. CONCLUSIONS: Subjects diagnosed with OSA had a higher incidence of peripheral vestibular disorders than those without OSA, according to national administrative claims data. It is recommended to take peripheral vertigo into account when counseling OSA.<\/jats:p>","DOI":"10.3233\/ves-210012","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T05:03:26Z","timestamp":1625893406000},"page":"155-162","source":"Crossref","is-referenced-by-count":24,"title":["Incidence of peripheral vestibular disorders in individuals with obstructive sleep apnea"],"prefix":"10.1177","volume":"32","author":[{"given":"Hayoung","family":"Byun","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea"},{"name":"Department of HY-KIST Bio-convergence, College of Medicine, Hanyang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hyeok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiin","family":"Ryu","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting and Research Laboratory, Medical Research Collaborating Center, Hanyang University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of 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