{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:53:27Z","timestamp":1782237207951,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VES"],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:p>BACKGROUND: The caloric vestibular test (CVT) may evoke headache and vestibular symptoms in susceptible people. Patients with migraines have higher susceptibility to motion sickness. In migraines, impaired habituation to repetitive stimuli is a well-known interictal abnormality. OBJECTIVE: This study is aimed at evaluating CVT-evoked headache, nausea, vomiting, and imbalance in patients with and without migraine and\/or motion sickness. METHODS: A retrospective data analysis was performed on 554 patients with a complaint of dizziness who underwent bithermal CVT at a tertiary referral center. The occurrences of CVT-evoked headache, nausea, vomiting, and imbalance were observed in four groups: patients with only migraine (MG; n\u200a=\u200a94), those with only motion sickness (MSG; n\u200a=\u200a89), those with migraine and motion sickness (MMSG; n\u200a=\u200a122), and those without migraine and motion sickness (non-MMSG; n\u200a=\u200a146). The differences between the groups were assessed. RESULTS: The mean ages of groups were similar (p\u200a=\u200a0.534). The proportions of females were higher in the MG, MSG, and MMSG (p\u200a=\u200a0.001). The severity of nausea and headache for each gender was higher in the MG, MSG, and MMSG (p\u200a&lt;\u200a0.001). Vomiting was more common in MMSG among males (p\u200a=\u200a0.003), while there was no difference between groups among females (p\u200a=\u200a0.099). Imbalance was more common in MMSG among females (p\u200a&lt;\u200a0.001). A relationship was detected between age and imbalance (p\u200a&lt;\u200a0.001), where an increased risk for imbalance was evident with greater age. Three patients in the MMSG needed hospitalization after CVT. CONCLUSIONS: Special caution is needed when performing caloric testing for patients with migraines or MS since CVT-evoked symptoms may occur with higher incidence and intensity, which might be related to a lack of habituation in neuronal information processing after robust sensory stimuli like CVT.<\/jats:p>","DOI":"10.3233\/ves-210046","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T01:33:08Z","timestamp":1633138388000},"page":"135-144","source":"Crossref","is-referenced-by-count":9,"title":["The effect of migraine and motion sickness on symptoms evoked by the caloric vestibular test"],"prefix":"10.1177","volume":"32","author":[{"given":"Ozlem","family":"Gedik-Soyuyuce","sequence":"first","affiliation":[{"name":"Audiology Department, Acibadem Maslak Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Yalinay-Dikmen","sequence":"additional","affiliation":[{"name":"Neurology Department, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazim","family":"Korkut","sequence":"additional","affiliation":[{"name":"ENT Department, Acibadem Maslak Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/VES-210046_ref1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1152\/jn.00481.2018","article-title":"Age-related reweighting of visual and vestibular cues for vertical perception","volume":"121","author":"Alberts","year":"2019","journal-title":"Journal of neurophysiology"},{"key":"10.3233\/VES-210046_ref2","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1468-2982.2007.01502.x","article-title":"The brain is hyperexcitable in migraine","volume":"27","author":"Aurora","year":"2007","journal-title":"Cephalalgia"},{"key":"10.3233\/VES-210046_ref3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1526-4610.2006.00311.x","article-title":"Gastric Stasis in Migraine: More Than Just a Paroxysmal Abnormality During a Migraine Attack: CME","volume":"46","author":"Aurora","year":"2006","journal-title":"Headache: The Journal of Head and Face Pain"},{"key":"10.3233\/VES-210046_ref4","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1212\/01.wnl.0000305959.46197.e6","article-title":"Association of gait and balance disorders with age-related white matter changes: the LADIS study","volume":"70","author":"Baezner","year":"2008","journal-title":"Neurology"},{"key":"10.3233\/VES-210046_ref5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2003.10.026","article-title":"Projections from the parabrachial nucleus to the vestibular nuclei: potential substrates for autonomic and limbic influences on vestibular responses","volume":"996","author":"Balaban","year":"2004","journal-title":"Brain research"},{"key":"10.3233\/VES-210046_ref6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00415-009-0038-8","article-title":"Psychiatric morbidity and comorbidity in different vestibular vertigo syndromes","volume":"256","author":"Best","year":"2009","journal-title":"Journal of Neurology"},{"key":"10.3233\/VES-210046_ref7","doi-asserted-by":"crossref","unstructured":"Borsook D. , Goadsby P.J. and Hargreaves R. , The migraine brain: imaging structure and function, Oxford University Press, 2012.","DOI":"10.1093\/acprof:oso\/9780199754564.001.0001"},{"key":"10.3233\/VES-210046_ref8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuron.2012.01.001","article-title":"Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load","volume":"73","author":"Borsook","year":"2012","journal-title":"Neuron"},{"key":"10.3233\/VES-210046_ref9","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1212\/01.wnl.0000176949.34080.64","article-title":"Both migraine and motion sickness may be due to low brain levels of serotonin","volume":"65","author":"Brey","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/VES-210046_ref10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10194-008-0095-x","article-title":"Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine","volume":"10","author":"Brighina","year":"2009","journal-title":"The journal of headache and pain"},{"key":"10.3233\/VES-210046_ref11","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","article-title":"Migraine: multiple processes, complex pathophysiology","volume":"35","author":"Burstein","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"10.3233\/VES-210046_ref12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.physio.2018.02.001","article-title":"Do patients with migraine experience an increased prevalence of falls and fear of falling? 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