{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:46:17Z","timestamp":1790833577305,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WOR"],"published-print":{"date-parts":[[2023,4,18]]},"abstract":"<jats:p>BACKGROUND: Long COVID describes a condition with symptoms that linger for months to years following acute COVID-19. Many of these Long COVID symptoms are like those experienced by patients with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). OBJECTIVE: We wanted to determine if people with Long COVID experienced post-exertional malaise (PEM), the hallmark symptom of ME\/CFS, and if so, how it compared to PEM experienced by patients with ME\/CFS. METHODS: A questionnaire that asked about the domains of PEM including triggers, experience, recovery, and prevention was administered to 80 people seeking care for Long COVID at Bateman Horne Center. Their responses were compared to responses about PEM given by 151 patients with ME\/CFS using chi-square tests of independence. RESULTS: All but one Long COVID respondent reported having PEM. There were many significant differences in the types of PEM triggers, symptoms experienced during PEM, and ways to recover and prevent PEM between Long COVID and ME\/CFS. Similarities between Long COVID and ME\/CFS included low and medium physical and cognitive exertion to trigger PEM, symptoms of fatigue, pain, immune reaction, neurologic, orthostatic intolerance, and gastrointestinal symptoms during PEM, rest to recover from PEM, and pacing to prevent PEM. CONCLUSION: People with Long COVID experience PEM. There were significant differences in PEM experienced by people with Long COVID compared to patients with ME\/CFS. This may be due to the newness of Long COVID, not knowing what exertional intolerance is or how to manage it.<\/jats:p>","DOI":"10.3233\/wor-220581","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T12:31:50Z","timestamp":1678451510000},"page":"1179-1186","source":"Crossref","is-referenced-by-count":59,"title":["Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)"],"prefix":"10.1177","volume":"74","author":[{"given":"Suzanne D.","family":"Vernon","sequence":"first","affiliation":[{"name":"The Bateman Horne Center of Excellence, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Hartle","sequence":"additional","affiliation":[{"name":"Drake University, Des Moines, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sullivan","sequence":"additional","affiliation":[{"name":"The Bateman Horne Center of Excellence, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bell","sequence":"additional","affiliation":[{"name":"The Bateman Horne Center of Excellence, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Abbaszadeh","sequence":"additional","affiliation":[{"name":"The Bateman Horne Center of Excellence, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Unutmaz","sequence":"additional","affiliation":[{"name":"Jackson Laboratory for Genomic Medicine, Farmington, CT, USA"},{"name":"University of Connecticut School of Medicine, Farmington, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Bateman","sequence":"additional","affiliation":[{"name":"The Bateman Horne Center of Excellence, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"5","key":"10.3233\/WOR-220581_ref1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.7861\/clinmed.2019-0035","article-title":"Chikungunya arthritis","volume":"19","author":"Pathak","year":"2019","journal-title":"Clin Med"},{"key":"10.3233\/WOR-220581_ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tmaid.2017.05.001","article-title":"Neuropsychological long-term sequelae of Ebola virus disease survivors \u2013 A systematic review","volume":"18","author":"L\u00f6tsch","year":"2017","journal-title":"Travel Med Infect Dis"},{"issue":"12","key":"10.3233\/WOR-220581_ref3","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1086\/518281","article-title":"The Long-Term Outcomes of Human West Nile Virus Infection","volume":"44","author":"Hughes","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.3233\/WOR-220581_ref4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2377-11-37","article-title":"Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study","volume":"11","author":"Moldofsky","year":"2011","journal-title":"BMC Neurol"},{"issue":"7568","key":"10.3233\/WOR-220581_ref5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/bmj.38933.585764.AE","article-title":"Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study","volume":"333","author":"Hickie","year":"2006","journal-title":"BMJ"},{"key":"10.3233\/WOR-220581_ref6","unstructured":"FDA (Food and Drug Administration). 2013. The voice of the patient: Chronic fatigue syndrome and myalgic encephalomyelitis. Bethesda, MD: Center for Drug Evaluation and Research (CDER), FDA."},{"issue":"11","key":"10.3233\/WOR-220581_ref7","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1016\/j.mayocp.2021.07.004","article-title":"Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management","volume":"96","author":"Bateman","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"10.3233\/WOR-220581_ref8","unstructured":"Beyond Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Redefining an Illness [Internet]. Washington, D.C.: National Academies Press; 2015 [cited 2022 Oct 6]. 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A Detailed Study of Patients with Long-Haul COVID. An Analysis of Private Healthcare Claims."},{"issue":"6","key":"10.3233\/WOR-220581_ref24","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s15010-021-01666-x","article-title":"Long COVID, a comprehensive systematic scoping review","volume":"49","author":"Akbarialiabad","year":"2021","journal-title":"Infection"}],"container-title":["Work"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/WOR-220581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:57:55Z","timestamp":1777615075000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/WOR-220581"}},"subtitle":[],"editor":[{"given":"Amy","family":"Mooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":24,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/wor-220581","relation":{},"ISSN":["1051-9815","1875-9270"],"issn-type":[{"value":"1051-9815","type":"print"},{"value":"1875-9270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]}}}