{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:44:40Z","timestamp":1777891480804,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T00:00:00Z","timestamp":1551484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of X-Ray Science and Technology"],"published-print":{"date-parts":[[2019,7,3]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To investigate associations between the clinicopathologic features and CT perfusion parameters of triple-negative breast cancer (TNBC) and non-TNBC using low-dose computed tomography perfusion imaging (LDCTPI), and to find potential clinical applications in the prognosis assessment of TNBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      A total of 60 patients with breast cancer confirmed by pathological examination were studied prospectively using LDCTPI on a 64-slice spiral CT scanner. The acquired volume data were used for calculations, mapping, and analysis by using a tumor perfusion protocol in the CT perfusion software package to measure 2 parameters namely, blood flow (BF), and permeability surface (PS) area product. Patients were grouped into TNBC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a27) and non-TNBC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a33) subtypes. Associations between these two subtypes and clinicopathologic characteristics were evaluated by both univariate and multivariate logistic regression. CT perfusion parameters values were compared for clinicopathologic characteristics using independent 2-sample\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      TNBC displayed higher CT perfusion parameters values (BF: 57.56\u00b110.94 vs 52.70\u00b17.79\u200amL\/100\u200ag\/min,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.006; PS: 38.98\u00b19.46 vs 33.39\u00b18.07\u200amL\/100\u200ag\/min,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.001) than non-TNBC. In addition, breast cancer with poorly histologic grade or positive Ki-67 expression showed higher BF and PS values than those with well and moderately histologic grade or negative Ki-67 expression (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.05). TNBC had poorer histologic grade (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u200a=\u200a0.032) and higher Ki-67 expression (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u200a=\u200a0.013) than non-TNBC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>LDCTPI is a functional imaging technology from the perspective of hemodynamics with potential of clinical applications. The BF and PS values were higher in TNBC patient group than non-TNBC group. TNBC patients also have poorer clinicopathologic outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/xst-180465","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T14:09:00Z","timestamp":1551794940000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A pilot study of low-dose CT perfusion imaging (LDCTPI) technology in patients with triple-negative breast cancer"],"prefix":"10.1177","volume":"27","author":[{"given":"Zong-Qiong","family":"Sun","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Jiangnan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Dong","family":"Hu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangnan 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