{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:45:40Z","timestamp":1777891540707,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n \n Since cancer treatment and outcome differ among the patients diagnosed with breast cancer at different stages, this study aims to elucidate the factors associated with PET\/CT staging, treatment effect, and maximal standardized uptake value (SUV\n max<\/jats:sub>\n ) in breast cancer patients.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n Twenty-eight patients who underwent two PET\/CT examinations with the complete pathological and immunohistochemical data were retrospectively reviewed. Pearson and Spearman correlation analyses were performed to investigate the relationships of patient PET\/CT staging (first round PET\/CT), treatment effect (comparison between the results of two rounds of PET\/CT), and tumor SUV\n max<\/jats:sub>\n , with respect to patient age, tumor location, tumor long diameter, short diameter, time of first round PET\/CT examination, histological type and grade, axillary lymph node metastasis rate, interval between the two PET\/CT examinations, treatment method, and the expression of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), P53, and Ki67.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n PET\/CT staging (first round PET\/CT) relates to HER2 and Ki67 expression with the correlation coefficients of 0.432 and 0.552, and P-values of 0.022 and 0.002, respectively. The treatment effect (comparison between the results of two rounds of PET\/CT) associates with tumor site and P53 expression in which the correlation coefficients are \u2013 0.412 and 0.845, and P-values are 0.029 and 0.000, respectively. The measured SUV\n max<\/jats:sub>\n correlates well with the tumor long diameter, short diameter, and treatment effect in which the correlation coefficients are 0.943, 0.886, and 0.878, and P-values are 0.005, 0.019, and 0.02, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n Study results indicate that PET\/CT staging and treatment effect associate well with SUV\n max<\/jats:sub>\n and immunohistochemical results of tumor, while SUV\n max<\/jats:sub>\n of tumor associates well with tumor size.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/xst-190544","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T07:30:54Z","timestamp":1568791854000},"page":"1131-1144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation analysis of\n 18<\/sup>\n F-FDG PET\/CT for the staging and treatment effect assessment of breast cancer"],"prefix":"10.1177","volume":"27","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Image, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongliang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of CT, The Weapons Industry of 521 Hospital, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youmin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Image, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiansheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Medical Image, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1159\/000442760"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2515-7"},{"issue":"4","key":"ref004","first-page":"4151","volume":"16","author":"Zhang F.C.","year":"2018","journal-title":"Oncol Lett"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv298"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.777003"},{"issue":"2","key":"ref007","first-page":"10","volume":"54","author":"Mannell 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