{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:48:20Z","timestamp":1777891700633,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["XST"],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:p>OBJECTIVES: To evaluate the feasibility of using coronary computed tomography angiography (CCTA)-derived strain to detect regional myocardial dysfunction in coronary artery disease (CAD) patients with normal left ventricular ejection fraction (LVEF). METHODS: A total of 1,580 segments from 101 patients who underwent stressed CT myocardial perfusion imaging (CT-MPI) and CCTA were retrospectively enrolled in this study. The CT-derived global and segmental strain values were evaluated using the feature tracking technique. Segments with myocardial blood flow (MBF) &lt;\u200a125\u200aml\/min\/100\u200aml and 95\u200aml\/min\/100\u200aml were categorized as ischemic and infarcted, respectively. RESULTS: Segmental radial strain (SRS) and segmental circumferential strain (SCS) in the abnormal segments (including all segments with MBF\u200a&lt;\u200a125\u200aml\/min\/100\u200aml) were significantly lower than those in the normal segments (14.81\u00b18.65% vs 17.17\u00b19.13%, p\u200a&lt;\u200a0.001; \u201310.21\u00b15.79% vs \u201311.86\u00b14.52%, p\u200a&lt;\u200a0.001, respectively). SRS and SCS values in infarcted segments were significantly impaired compared with the ischemic segments (12.43\u00b18.03% vs. 15.32\u00b18.71%, p\u200a=\u200a0.038; \u20137.72\u00b15.91% vs. \u201310.67\u00b15.66%, p\u200a=\u200a0.010, respectively). The AUCs for SRS and SCS in detecting infarcted segments were 0.622 and 0.698, respectively (p\u200a&lt;\u200a0.05). CONCLUSIONS: It is feasible for using CCTA-derived strain parameters to detect regional myocardial dysfunction in CAD patients with preserved LVEF. Segmental radial and circumferential strain have the potential ability to distinguish myocardial ischemia from infarction, and normal from ischemic myocardium.<\/jats:p>","DOI":"10.3233\/xst-211104","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T13:58:27Z","timestamp":1646747907000},"page":"587-597","source":"Crossref","is-referenced-by-count":0,"title":["CCTA-derived strain analysis in detection of regional myocardial dysfunction in coronary artery disease patients with preserved left ventricular ejection fraction: A feasibility study"],"prefix":"10.1177","volume":"30","author":[{"given":"Mengmeng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqian","family":"Ge","sequence":"additional","affiliation":[{"name":"Siemens Healthineers, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinsu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/XST-211104_ref1","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.3233\/XST-211104_ref2","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s00330-014-3221-y","article-title":"Meta-analysis: diagnostic accuracy of coronary CT angiography with prospective ECG gating based on step-and-shoot, flash and volume modes for detection of coronary artery 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