{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:49:40Z","timestamp":1777891780402,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics"],"published-print":{"date-parts":[[2023,1,27]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Anemia is an important clinical symptom for aplastic anemia (AA) patients who are suffered with peripheral pancytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To evaluate the accuracy of diagnosing anemia with non-invasive chest computed tomography (CT) for AA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The CT attenuation of left ventricular (LV) cavity and interventricular septum (IVS) on unenhanced thoracic CT images of AA patients are retrospectively analyzed, including 84 AA patients in pre-transplant and 1-month ( n\u200a=\u200a82), 2-month ( n\u200a=\u200a72), 3-month ( n\u200a=\u200a75), 6-month ( n\u200a=\u200a74) and 12-month ( n\u200a=\u200a70) followed patients in post-transplant. The difference (IVS-LV) and ratio (LV\/IVS) of the CT attenuation between LV cavity and interventricular septum are calculated. Serum hemoglobin is estimated within 24 hours of CT imaging. The CT attenuations of IVS-LV and LV\/IVS are correlated with hemoglobin, and their variation tendency is analyzed during the treatment of a-HSCT. A receiver operating characteristic (ROC) curve analysis is then performed for the diagnosis of anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The CT attenuations of IVS-LV and LV\/IVS well correlate with hemoglobin ( r\u200a=\u200a\u20130.618 and 0.628, respectively, P\u200a&lt; \u200a0.001). The variation tendency of IVS-LV and LV\/IVS is similar to that of hemoglobin with opposite directions during one-year follow-up of a-HSCT. When a threshold of CT attenuation of IVS-LV and LV\/IVS is set at 11.5HU and 0.77, respectively, both the sensitivity and specificity in diagnosing anemia are good (74.7% and 73.8% in CT attenuation of IVS-LV; 77.4% and 70.4% in LV\/LVS, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Both CT attenuation of LV\/IVS and IVS-LV had similar accuracy in diagnosing anemia for AA patients. The non-invasive chest CT can offer a new possibility to complementarily evaluate anemia for AA patients in the diagnostic radiology reports.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/xst-221296","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T11:15:28Z","timestamp":1669115728000},"page":"199-209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility of thoracic CT in assessing anemia for aplastic anemia patients undergoing allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1177","volume":"31","author":[{"given":"Dandan","family":"Chen","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China"},{"name":"Department of Radiology, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjian","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Wei","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China"},{"name":"Department of Radiology, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-017-0511-z"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15443"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2017.1302797"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018021162"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000306"},{"issue":"1","key":"ref006","first-page":"26","volume":"54","author":"Foster M.","year":"2003","journal-title":"Can Assoc Radiol 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