{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:27:18Z","timestamp":1780601238053,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics"],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Try to create a dose gradient function (DGF) and test its effectiveness in reducing radiation induced lung injury in breast cancer radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>Radiotherapy plans of 30 patients after breast-conserving surgery were included in the study. The dose gradient function was defined as [Formula: see text], then the area under the DGF curve of each plan was calculated in rectangular coordinate system, and the minimum area was used as the trigger factor, and other plans were triggered to optimize for area reduction. The dosimetric parameters of target area and organs at risk in 30 cases before and after re-optimization were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      On the premise of ensuring that the target dose met the clinical requirements, the trigger factor obtained based on DGF could further reduce the V\n                      <jats:sub>5<\/jats:sub>\n                      , V\n                      <jats:sub>10<\/jats:sub>\n                      , V\n                      <jats:sub>20<\/jats:sub>\n                      , V\n                      <jats:sub>30<\/jats:sub>\n                      and mean lung dose (MLD) of the ipsilateral lung in breast cancer radiotherapy, P\u200a&lt;\u200a0.01. And the D\n                      <jats:sub>2cc<\/jats:sub>\n                      and mean heart dose (MHD) of the heart were also reduced, P\u200a&lt;\u200a0.01. Besides, the NTCPs of the ipsilateral lung and the heart were also reduced, P\u200a&lt;\u200a0.01.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The trigger factor obtained based on DGF is efficient in reducing radiation induced lung injury in breast cancer radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/xst-230198","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T10:49:05Z","timestamp":1704451745000},"page":"415-426","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of dose-gradient function in reducing radiation induced lung injury in breast cancer radiotherapy"],"prefix":"10.1177","volume":"32","author":[{"given":"Han","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Cancer Center of Yunnan Province, Xishan District, Kunming, Yunnan, People\u2019s Republic of China"},{"name":"Department of Physics and Astronomy, Yunnan University, Kunming, Yunnan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Cancer Center of Yunnan Province, Xishan District, Kunming, Yunnan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Cancer Center of Yunnan Province, Xishan District, Kunming, Yunnan, People\u2019s Republic of 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