{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:43:13Z","timestamp":1777498993256,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Beh\u00e7et's disease (BD) is a rare chronic vasculitis of unclear etiology. It has been suggested that inflammatory response has an important role in BD pathophysiology. Herein, we aimed to study the interplay between inflammation, iron metabolism and endothelial function in BD and search for its putative association with disease activity. Twenty five patients clinically diagnosed with BD were selected and twenty four healthy age-sex matched individuals participated as controls. Results showed an increase of total number of circulating white blood cells and neutrophils, serum transferrin, total iron binding capacity, mieloperoxidase (MPO), ceruloplasmin (Cp), C reactive protein, \u03b22 microglobulin and Cp surface expression in peripheral blood monocytes in BD patients comparatively to healthy individuals (p &lt; 0,05). Of notice, the alterations observed were associated to disease activity status. No significant differences between the two groups were found in serum nitric oxide concentration. The results obtained suggest an important contribution from innate immunity in the pathogenesis of this disease. In particular, surface expression of leukocyte-derived Cp may constitute a new and relevant biomarker to understand BD etiology.<\/jats:p>","DOI":"10.3233\/ch-131725","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:39:34Z","timestamp":1575293974000},"page":"175-185","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Crosstalk between inflammation, iron metabolism and endothelial function in Beh\u00e7et's disease"],"prefix":"10.1177","volume":"56","author":[{"given":"Rita","family":"Oliveira","sequence":"first","affiliation":[{"name":"Instituto Nacional de Sa\u00fade Dr Ricardo Jorge I.P., Lisboa, Portugal"}]},{"given":"Patricia","family":"Napole\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}]},{"given":"Jo\u00e3o","family":"Banha","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade Dr Ricardo Jorge I.P., Lisboa, Portugal"},{"name":"Centro para a Biodiversidade, Gen\u00f3mica Integrativa e Funcional, Faculdade de Ci\u00eancias, Universidade de Lisboa, Lisboa, Portugal"}]},{"given":"Eleonora","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade Dr Ricardo Jorge I.P., Lisboa, Portugal"}]},{"given":"Andreia","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"}]},{"given":"Berta Martins","family":"da Silva","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"}]},{"given":"Dina","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hospital Reinaldo dos Santos, Vila Franca De Xira, Portugal"}]},{"given":"Filipe","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Reumatologia, Lisboa, Portugal"}]},{"given":"Ana","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Reumatologia, Lisboa, Portugal"}]},{"given":"Jos\u00e9 Vaz","family":"Patto","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Reumatologia, Lisboa, Portugal"}]},{"given":"Ana Maria","family":"Viegas-Crespo","sequence":"additional","affiliation":[{"name":"CESAM, Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade de Lisboa, Lisboa, Portugal"}]},{"given":"Luciana","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade Dr Ricardo Jorge I.P., Lisboa, Portugal"},{"name":"Centro para a Biodiversidade, Gen\u00f3mica Integrativa e Funcional, Faculdade de Ci\u00eancias, Universidade de Lisboa, Lisboa, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-131725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/CH-131725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:11:10Z","timestamp":1777389070000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/CH-131725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.3233\/CH-131725"],"URL":"https:\/\/doi.org\/10.3233\/ch-131725","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}