{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:37:39Z","timestamp":1777394259214,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2015,9,9]]},"DOI":"10.3233\/jad-150342","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T20:00:48Z","timestamp":1441828848000},"page":"433-441","source":"Crossref","is-referenced-by-count":38,"title":["Validation of the Erlangen Score Algorithm for the Prediction of the Development of\u00a0Dementia due to Alzheimer\u2019s Disease in\u00a0Pre-Dementia Subjects"],"prefix":"10.1177","volume":"48","author":[{"given":"Piotr","family":"Lewczuk","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}]},{"name":"on behalf of the German Dementia Competence Network","sequence":"additional","affiliation":[]},{"name":"on behalf of the US-ADNI","sequence":"additional","affiliation":[]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Universit\u00e4tsklinikum Erlangen, and Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}]},{"given":"Jon B.","family":"Toledo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}]},{"given":"Malgorzata","family":"Knapik-Czajka","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 Berlin, Berlin, Germany"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Georg-August Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Germany"}]},{"given":"Leslie M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-150342_ref1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150342_ref2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150342_ref3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1474-4422(06)70355-6","article-title":"Association between CSF biomarkers and incipient Alzheimer\u2019s disease in patients with mild cognitive impairment: A follow-up study","volume":"5","author":"Hansson","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150342_ref4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2003.08.011","article-title":"Cerebrospinal fluid markers for prediction of Alzheimer\u2019s disease","volume":"352","author":"Zetterberg","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-150342_ref5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00401-011-0808-0","article-title":"Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI","volume":"121","author":"Shaw","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-150342_ref6","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00702-009-0277-y","article-title":"Neurochemical dementia diagnostics: A simple algorithm for interpretation of the CSF biomarkers","volume":"116","author":"Lewczuk","year":"2009","journal-title":"J\u00a0Neural Transm"},{"key":"10.3233\/JAD-150342_ref7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3233\/JAD-131634","article-title":"Concentrations of matrix metalloproteinases and their tissue inhibitors in the cerebrospinal fluid of patients with Alzheimer\u2019s disease","volume":"40","author":"Mroczko","year":"2014","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.3233\/JAD-150342_ref8","doi-asserted-by":"crossref","first-page":"386 e386","DOI":"10.1016\/j.jalz.2011.05.2243","article-title":"The Alzheimer\u2019s Association external quality control program for cerebrospinal fluid biomarkers","volume":"7","author":"Mattsson","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-150342_ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2006.07.009","article-title":"International quality control survey of neurochemical dementia diagnostics","volume":"409","author":"Lewczuk","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-150342_ref10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150342_ref11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1159\/000210388","article-title":"Early and differential diagnosis of dementia and mild cognitive impairment: Design and cohort baseline characteristics of the German Dementia Competence Network","volume":"27","author":"Kornhuber","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-150342_ref12","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00702-006-0511-9","article-title":"The German Competence Net Dementias: Standard operating procedures for the neurochemical dementia diagnostics","volume":"113","author":"Lewczuk","year":"2006","journal-title":"J\u00a0Neural Transm"},{"key":"10.3233\/JAD-150342_ref13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1385\/JMN:23:1-2:115","article-title":"Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer\u2019s disease: Original Data and Review of the Literature","volume":"23","author":"Lewczuk","year":"2004","journal-title":"J\u00a0Mol Neurosci"},{"key":"10.3233\/JAD-150342_ref14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0197-4580(03)00086-1","article-title":"Neurochemical diagnosis of Alzheimer\u2019s dementia by CSF Ab42, Ab42\/Ab40 ratio and total tau","volume":"25","author":"Lewczuk","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-150342_ref15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in Alzheimer\u2019s disease neuroimaging initiative subjects","volume":"65","author":"Shaw","year":"2009","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150342_ref16","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1212\/WNL.52.8.1555","article-title":"Improved discrimination of AD patients using b-amyloid(1-42) and tau levels in CSF","volume":"52","author":"Hulstaert","year":"1999","journal-title":"Neurology"},{"key":"10.3233\/JAD-150342_ref17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: An updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-150342_ref18","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1212\/01.wnl.0000435556.21319.e4","article-title":"Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity","volume":"81","author":"Jack","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-150342_ref19","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1471-4159.2006.04404.x","article-title":"Amyloid beta peptide ratio 42\/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load","volume":"101","author":"Wiltfang","year":"2007","journal-title":"J\u00a0Neurochem"},{"key":"10.3233\/JAD-150342_ref20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000100926","article-title":"Prediction of Alzheimer\u2019s disease using the CSF Abeta42\/Abeta40 ratio in patients with mild cognitive impairment","volume":"23","author":"Hansson","year":"2007","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-150342_ref21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3233\/JAD-130107","article-title":"Cerebrospinal fluid Abeta1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels","volume":"36","author":"Slaets","year":"2013","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.3233\/JAD-150342_ref22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3233\/JAD-2012-121267","article-title":"Confirmation of the amyloidogenic process in posterior cortical atrophy: Value of the Abeta42\/Abeta40 ratio","volume":"33","author":"Beaufils","year":"2013","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.3233\/JAD-150342_ref23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-140771","article-title":"Amyloid \u03b2 42\/40 CSF concentration ratio in the diagnostics of Alzheimer\u2019s Disease: Validation of two novel assays","volume":"43","author":"Lewczuk","year":"2015","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.3233\/JAD-150342_ref24","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/archneur.63.5.665","article-title":"Neuropathologic features of amnestic mild cognitive impairment","volume":"63","author":"Petersen","year":"2006","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-150342_ref25","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.21706","article-title":"The neuropathology of probable Alzheimer disease and mild cognitive impairment","volume":"66","author":"Schneider","year":"2009","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-150342_ref26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00002093-199205000-00004","article-title":"Clinically diagnosed Alzheimer disease: Neuropathologic findings in 650 cases","volume":"6","author":"Mendez","year":"1992","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-150342_ref27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3233\/JAD-2010-100207","article-title":"Evaluation of CSF biomarkers as predictors of Alzheimer\u2019s disease: A clinical follow-up study of 4.7 years","volume":"21","author":"Hertze","year":"2010","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.3233\/JAD-150342_ref28","doi-asserted-by":"crossref","first-page":"a006213","DOI":"10.1101\/cshperspect.a006213","article-title":"Brain imaging in Alzheimer disease","volume":"2","author":"Johnson","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.3233\/JAD-150342_ref29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","article-title":"Introduction to the recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimers Dement"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-150342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:02:48Z","timestamp":1777370568000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-150342"}},"subtitle":[],"editor":[{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,9,9]]},"references-count":29,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-150342","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,9]]}}}