{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:38:41Z","timestamp":1777394321786,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,1,24]]},"abstract":"<jats:p>\n                    Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer\u2019s disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    , total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV\/TIV ratio or not, was determined by ROC analysis. CSF A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    levels inversely correlated to VV\/TIV in the whole study population (A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    : r\u200a=\u200a\u20130.28; p\u200a&lt;\u200a0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r\u200a=\u200a\u20130.15; p-tau: r\u200a=\u200a\u20130.13; both p\u200a&lt;\u200a0.01). Correction for differences in VV\/TIV improved the differentiation of AD versus controls based on CSF A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    levels.\n                  <\/jats:p>","DOI":"10.3233\/jad-160668","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T12:17:00Z","timestamp":1483705020000},"page":"543-555","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer\u2019s Disease Patients and Controls after Correction for Ventricular Volumes"],"prefix":"10.1177","volume":"56","author":[{"given":"Linda J.C.","family":"van Waalwijk van Doorn","sequence":"first","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands"},{"name":"Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands"}]},{"given":"Juan D.","family":"Gispert","sequence":"additional","affiliation":[{"name":"Barcelona Beta Brain Research Centre, Pasqual Maragall Foundation, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain"},{"name":"Pompeu Fabra University, Barcelona, Spain"}]},{"given":"H. Bea","family":"Kuiperij","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands"},{"name":"Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands"}]},{"given":"Jurgen A.H.R.","family":"Claassen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[{"name":"University of Milan, Fondazione Ca\u2019 Granda, IRCCS Ospedale Policlinico, Milan, Italy"}]},{"given":"In\u00eas","family":"Baldeiras","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology (CNC.IBILI), Faculty of Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}]},{"given":"Marco","family":"Bozzali","sequence":"additional","affiliation":[{"name":"Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy"}]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Imaging and Life Sciences (CNC.IBILI) and ICNAS (Institute for Nuclear Sciences Applied to Health), University of Coimbra, Portugal"}]},{"given":"Enrica","family":"Cavedo","sequence":"additional","affiliation":[{"name":"AXA Research Fund and UPMC Chair, Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM), D\u00e9partement de Neurologie, Institut de la M\u00e9moire et de la Maladie d\u2019Alzheimer (IM2A), H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Boulevard de l\u2019h\u00f4pital, F-75013, Paris, France"}]},{"given":"Derya D.","family":"Emek-Sava\u015f","sequence":"additional","affiliation":[{"name":"Department of Psychology, The Faculty of Arts, Department of Neurosciences, The Health Sciences Institute, Dokuz Eyl\u00fcl University, Izmir, Turkey"}]},{"given":"Erden","family":"Eren","sequence":"additional","affiliation":[{"name":"Izmir Biomedicine and Genome Institute, Department of Neurosciences, The Health Sciences Institute, Dokuz Eyl\u00fcl University, Izmir, Turkey"}]},{"given":"Paolo","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy"}]},{"given":"Lucia","family":"Farotti","sequence":"additional","affiliation":[{"name":"Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[{"name":"University of Milan, Fondazione Ca\u2019 Granda, IRCCS Ospedale Policlinico, Milan, Italy"}]},{"given":"Juan Fortea","family":"Ormaechea","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Sant Pau, Barcelona, Spain"}]},{"given":"Yvonne","family":"Freund-Levi","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy"},{"name":"University Hospitals and University of Geneva, Geneva, Switzerland"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"University of Milan, Fondazione Ca\u2019 Granda, IRCCS Ospedale Policlinico, Milan, Italy"}]},{"given":"Sermin","family":"Genc","sequence":"additional","affiliation":[{"name":"Izmir Biomedicine and Genome Institute, Department of Neurosciences, The Health Sciences Institute, Dokuz Eyl\u00fcl University, Izmir, Turkey"}]},{"given":"Viviana","family":"Greco","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Unit, IRCCS-Fondazione Santa Lucia, Rome, Italy"}]},{"given":"Harald","family":"Hampel","sequence":"additional","affiliation":[{"name":"AXA Research Fund and UPMC Chair, Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM), D\u00e9partement de Neurologie, Institut de la M\u00e9moire et de la Maladie d\u2019Alzheimer (IM2A), H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Boulevard de l\u2019h\u00f4pital, F-75013, Paris, France"}]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland"}]},{"given":"Yawu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland"}]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, IDIBAPS, Barcelona, Spain"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Sant Pau, Barcelona, Spain"}]},{"given":"Flavio M.","family":"Nobili","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy"}]},{"given":"Kader K.","family":"Oguz","sequence":"additional","affiliation":[{"name":"Hacettepe University, Faculty of Medicine, Department of Neurology, Sihhiye, Ankara, Turkey"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy"}]},{"given":"Jo\u00e3o","family":"Pereira","sequence":"additional","affiliation":[{"name":"Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy"}]},{"given":"Agnese","family":"Picco","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy"}]},{"given":"Maria","family":"Pikkarainen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland"}]},{"given":"Catarina Resende","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology (CNC.IBILI), Faculty of Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Esen","family":"Saka","sequence":"additional","affiliation":[{"name":"Hacettepe University, Faculty of Medicine, Department of Neurology, Sihhiye, Ankara, Turkey"}]},{"given":"Nicola","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy"}]},{"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, IDIBAPS, Barcelona, Spain"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology (CNC.IBILI), Faculty of Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[{"name":"University of Milan, Fondazione Ca\u2019 Granda, IRCCS Ospedale Policlinico, Milan, Italy"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Alzheimer center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, 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Italy"}]},{"given":"Eduard","family":"Vilaplana","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Sant Pau, Barcelona, Spain"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[{"name":"Alzheimer center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands"},{"name":"Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands"}]},{"given":"Asa K.","family":"Wallin","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6, Lund University, Malm\u00f6, Sweden"}]},{"given":"G\u00f6rsev","family":"Yener","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School Izmir, 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