{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:59:30Z","timestamp":1762376370300,"version":"3.38.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,3,27]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Although the diagnosis of mild cognitive impairment (MCI) corresponds to a condition likely to progress to dementia, essentially Alzheimer\u2019s disease, longitudinal studies have shown that some patients may not convert to dementia and maintain the diagnosis of MCI even after many years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To determine whether patients that maintain the diagnosis of MCI in the long term (10 years) are really stable or just declining slowly, and to identify clinical and neuropsychological characteristics associated with long-term stability. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> The Cognitive Complaints Cohort (CCC) was searched for MCI cases who maintained that diagnosis for at least 10 years. For each long-term-stable MCI patient, two MCI patients that converted to dementia during follow-up, matched for age and education, were selected from the same database. The baseline and last neuropsychological evaluations for long-term-stable MCI and converter MCI were compared. Baseline neuropsychological predictors of long-term stability were searched for. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Long-term-stable MCI ( n\u200a=\u200a22) and converter MCI ( n\u200a=\u200a44) patients did not differ in terms of gender distribution, education, age at first assessment and time between symptom onset and first evaluation. Time of follow-up was on average 11 years for long-term-stable MCI and 3 years for converter MCI. The baseline and follow-up neuropsychological tests were not significantly different in long-term-stable MCI patients, whereas a general decline was observed in converter MCI patients. Higher scores on one memory test, the Word Delayed Total Recall, and on the non-verbal abstraction test, Raven\u2019s Progressive Matrices, at the baseline predicted long-term (10 years) clinical stability. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Some patients with MCI remain clinically and neuropsychologically stable for a decade. Better performances at baseline in memory and non-verbal abstraction tests predict long-term stability. <\/jats:p><\/jats:sec>","DOI":"10.3233\/jad-171034","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T09:23:47Z","timestamp":1522229027000},"page":"1703-1711","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Neuropsychological Predictors of Long-Term (10 Years) Mild Cognitive Impairment Stability"],"prefix":"10.1177","volume":"62","author":[{"given":"Lu\u00edsa","family":"Alves","sequence":"first","affiliation":[{"name":"Chronic Diseases Research Center, NOVA Medical School, NOVA University of Lisbon, Lisbon, Portugal"}]},{"given":"Sandra","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon, Lisbon, Portugal"}]},{"given":"Jo\u00e3o","family":"Maroco","sequence":"additional","affiliation":[{"name":"Instituto Superior de Psicologia Aplicada, Lisbon, Portugal"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon, Lisbon, Portugal"}]},{"given":"Manuela","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon, Lisbon, Portugal"}]},{"given":"Dina","family":"Silva","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Research Group, Department of Psychology and Educational Sciences and Centre for Biomedical Research (CBMR), Universidade do Algarve, Faro, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.9.1136"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.12.1985"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.015032"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21326"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.266"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01326.x"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.07.055"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238517.59286.c5"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-299"},{"key":"ref012","unstructured":"GarciaC (1984) Doen\u00e7a de Alzheimer, problemas do diagn\u00f3stico cl\u00ednico. Tese de Doutoramento, Faculdade de Medicina de Lisboa."},{"key":"ref013","unstructured":"GuerreiroM (1998) Contributo da Neuropsicologia para o Estudo das Dem\u00eancias. Disserta\u00e7\u00e3o de Doutoramento em Ci\u00eancias Biom\u00e9dicas, Faculdade de Medicina de Lisboa."},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000249117.23318.e1"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/9.3_Part_1.179"},{"key":"ref018","unstructured":"American Psychiatric Association (2000) DSM-IV-TR.APA, 4th edition, text revision, Washington, DC."},{"key":"ref019","first-page":"71","volume-title":"Escalas e Testes na Dem\u00eancia","author":"Barreto J","year":"2008","edition":"3"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90033-4"},{"key":"ref021","first-page":"165","volume-title":"Clinical Gerontology: A Guide to Assessment and Intervention","author":"Sheikh JI","year":"1986"},{"key":"ref022","unstructured":"WechslerD (1969) Manuel de l\u2019\u00e9chelle clinique de m\u00e9moire. Centre de Psychologie Appliqu\u00e9e, Paris."},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199910)14:10<858::AID-GPS35>3.0.CO;2-8"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000179092.59909.42"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.136903"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14070878"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000279336.36610.f7"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1159\/000336224"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31823038c6"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-017-9361-5"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.034"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.916"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000258542.58725.4c"},{"key":"ref034","first-page":"12","volume":"2","author":"Li S","year":"2013","journal-title":"Am J Alzheimers Dis (Columbia)"},{"volume-title":"Coloured progressive matrices: Sets A, AB, B","year":"1956","author":"Raven JC","key":"ref035"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh144"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.6.808"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709090857"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70191-6"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2073"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151034"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150570"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.03.034"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-171034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-171034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-171034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T20:33:23Z","timestamp":1741638803000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-171034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,27]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,3,27]]}},"alternative-id":["10.3233\/JAD-171034"],"URL":"https:\/\/doi.org\/10.3233\/jad-171034","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"type":"print","value":"1387-2877"},{"type":"electronic","value":"1875-8908"}],"subject":[],"published":{"date-parts":[[2018,3,27]]}}}