{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:22:15Z","timestamp":1777396935212,"version":"3.51.4"},"reference-count":59,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,5,7]]},"DOI":"10.3233\/jad-180152","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T18:35:44Z","timestamp":1528828544000},"page":"3-14","source":"Crossref","is-referenced-by-count":19,"title":["Predicting and Tracking Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer\u2019s Disease: Structural Brain Biomarkers"],"prefix":"10.1177","volume":"69","author":[{"given":"Moira","family":"Marizzoni","sequence":"first","affiliation":[{"name":"Laboratory of Neuroimaging and Alzheimer\u2019s Epidemiology, IRCCS Istituto Centro San Giovanni diDio Fatebenefratelli, Brescia, Italy"}]},{"name":"The PharmaCog Consortium","sequence":"additional","affiliation":[]},{"given":"Clarissa","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Unit of Statistics, IRCCS Istituto Centro San Giovanni diDio Fatebenefratelli, Brescia, Italy"}]},{"given":"Jorge","family":"Jovicich","sequence":"additional","affiliation":[{"name":"Center for Mind\/Brain Sciences, University of Trento, Italy"}]},{"given":"Diego","family":"Albani","sequence":"additional","affiliation":[{"name":"Neuroscience Department, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy"}]},{"given":"Claudio","family":"Babiloni","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d, Sapienza University of Rome, Rome, Italy"},{"name":"IRCCS San Raffaele Pisana of Rome, Rome, Italy"}]},{"given":"Libera","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging and Alzheimer\u2019s Epidemiology, IRCCS Istituto Centro San Giovanni diDio Fatebenefratelli, Brescia, Italy"}]},{"given":"Mira","family":"Didic","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, Inserm, INS UMR_S 1106, Marseille, France"},{"name":"APHM, Timone, Service de Neurologie et Neuropsychologie, APHM H\u00f4pital Timone Adultes, Marseille, France"}]},{"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[{"name":"Neuroscience Department, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy"}]},{"given":"Samantha","family":"Galluzzi","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging and Alzheimer\u2019s Epidemiology, IRCCS Istituto Centro San Giovanni diDio Fatebenefratelli, Brescia, Italy"}]},{"given":"Karl-Titus","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Leipzig, Leipzig, Germany"}]},{"given":"Jos\u00e9 Luis","family":"Molinuevo","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Unit and Other Cognitive Disorders Unit, Hospital Cl\u00ednic de Barcelona, and Institut d\u2019Investigacions Biom\u00e9diques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, Spain"}]},{"given":"Flavio","family":"Nobili","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Dept. of Neuroscience (DINOGMI), University of Genoa and IRCCS AOU SanMartino-IST, Genoa, Italy"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Clinica Neurologica, Universit\u00e0 di Perugia, Ospedale Santa Mariadella Misericordia, Perugia, Italy"}]},{"given":"Pierre","family":"Payoux","sequence":"additional","affiliation":[{"name":"INSERM; Imagerie c\u00e9r\u00e9brale et handicapsneurologiques UMR 825, Toulouse, France"}]},{"given":"Federica","family":"Ribaldi","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging and Alzheimer\u2019s Epidemiology, IRCCS Istituto Centro San Giovanni diDio Fatebenefratelli, Brescia, Italy"},{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}]},{"given":"Paolo Maria","family":"Rossini","sequence":"additional","affiliation":[{"name":"Area of Neuroscience, Department of Gerontology, Neurosciences & Orthopedics, Catholic University, Policlinic A. Gemelli Foundation Rome, Italy"}]},{"given":"Peter","family":"Sch\u00f6nknecht","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany"}]},{"given":"Marco","family":"Salvatore","sequence":"additional","affiliation":[{"name":"SDN Istituto di Ricerca Diagnostica e Nucleare, Napoli, Italy"}]},{"given":"Andrea","family":"Soricelli","sequence":"additional","affiliation":[{"name":"SDN Istituto di Ricerca Diagnostica e Nucleare, Napoli, Italy"}]},{"given":"Tilman","family":"Hensch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany"}]},{"given":"Magda","family":"Tsolaki","sequence":"additional","affiliation":[{"name":"3rd Neurologic Clinic, Medical School, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, The Netherlands"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany"},{"name":"Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Goettingen, Germany"},{"name":"iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal"}]},{"given":"Jill C.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, United Kingdom"}]},{"given":"R\u00e9gis","family":"Bordet","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU Lille, U1171 - Degenerative and vascular cognitive disorders, Lille, France"}]},{"given":"Olivier","family":"Blin","sequence":"additional","affiliation":[{"name":"Aix Marseille University, UMR-CNRS 7289, Service de Pharmacologie Clinique, AP-HM, Marseille, France"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging and Alzheimer\u2019s Epidemiology, IRCCS Istituto Centro San Giovanni diDio Fatebenefratelli, Brescia, Italy"},{"name":"Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-180152_ref1","first-page":"A12","article-title":"NerveCenter: Phase III Alzheimer trial halted:Search for therapeutic biomarkers continues","volume":"68","author":"Fleisher","year":"2010","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-180152_ref2","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1001\/jama.2009.1866","article-title":"Effect oftarenflurbil on cognitive decline and activities of daily living inpatients with mild Alzheimer disease: A randomized controlled trial","volume":"302","author":"Green","year":"2009","journal-title":"JAMA"},{"key":"10.3233\/JAD-180152_ref3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jalz.2013.03.007","article-title":"Designing drug trials for Alzheimer\u2019s disease: What we have learnedfrom the release of the phase III antibody trials: A report from the EU\/US\/ CTAD Task Force","volume":"9","author":"Vellas","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180152_ref4","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale forAlzheimer\u2019s disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am J Psychiatry"},{"key":"10.3233\/JAD-180152_ref5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2125.2012.04308.x","article-title":"Disease progression modelin subjects with mild cognitive impairment from the Alzheimer\u2019sdisease neuroimaging initiative: CSF biomarkers predict populationsubtypes","volume":"75","author":"Samtani","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"10.3233\/JAD-180152_ref6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/alzrt52","article-title":"Assessing the progression of mildcognitive impairment to Alzheimer\u2019s disease: Current trends andfuture directions","volume":"2","author":"Brooks","year":"2010","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-180152_ref7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neurobiolaging.2012.03.006","article-title":"Estimating sample sizes for predementia Alzheimer\u2019s trials based on the Alzheimer\u2019s Disease Neuroimaging Initiative","volume":"34","author":"Grill","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180152_ref8","doi-asserted-by":"crossref","first-page":"e47739","DOI":"10.1371\/journal.pone.0047739","article-title":"Enrichment and stratification for predementia Alzheimer disease clinical trials","volume":"7","author":"Holland","year":"2012","journal-title":"PLoS One"},{"key":"10.3233\/JAD-180152_ref9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1212\/WNL.0000000000003126","article-title":"Enrichment of clinical trials in MCI due to AD using markers of amyloid and neurodegeneration","volume":"87","author":"Wolz","year":"2016","journal-title":"Neurology"},{"key":"10.3233\/JAD-180152_ref10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jalz.2013.07.003","article-title":"Coalition Against Major Diseases\/European Medicines Agency biomarkerqualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer\u2019s disease","volume":"10","author":"Hill","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180152_ref11","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/brain\/awp007","article-title":"MRI of hippocampal volumeloss in early Alzheimers disease in relation to ApoE genotype andbiomarkers","volume":"132","author":"Schuff","year":"2009","journal-title":"Brain"},{"key":"10.3233\/JAD-180152_ref12","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.neurobiolaging.2013.02.002","article-title":"Measurements of medial temporal lobe atrophy forprediction of Alzheimer\u2019s disease in subjects with mild cognitive impairment","volume":"34","author":"Clerx","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180152_ref13","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1212\/WNL.0b013e318281ccd3","article-title":"Cerebral atrophy in mild cognitive impairment and Alzheimerdisease: Rates and acceleration","volume":"80","author":"Leung","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-180152_ref14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.dadm.2015.11.002","article-title":"Cerebral atrophy inmild cognitive impairment: A systematic review with meta-analysis","volume":"1","author":"Tabatabaei-Jafari","year":"2015","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.3233\/JAD-180152_ref15","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1159\/000258100","article-title":"Patterns of cortical thickness according to APOE genotype in alzheimer\u2019sdisease","volume":"28","author":"Guti\u00e9rrez-Galve","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-180152_ref16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fnagi.2013.00055","article-title":"Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampalvolume with spinal fluid amyloid-\u03b2 and tau","volume":"5","author":"Dickerson","year":"2013","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-180152_ref17","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3233\/JAD-142631","article-title":"Corpus callosum atrophy rate in mild cognitive impairment and prodromalAlzheimer\u2019s disease","volume":"45","author":"Elahi","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-180152_ref18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.dadm.2016.01.003","article-title":"Predicting progression from mild cognitive impairment to Alzheimer\u2019s disease using longitudinal callosal atrophy","volume":"2","author":"Lee","year":"2016","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.3233\/JAD-180152_ref19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jns.2008.12.009","article-title":"Abnormal integrity of association fiber tracts in amnestic mildcognitive impairment","volume":"278","author":"Bai","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-180152_ref20","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/joim.12482","article-title":"Clinical and biomarker profiling of prodromal Alzheimer\u2019sdisease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: A \u201cEuropean ADNI study.\u201d","volume":"279","author":"Galluzzi","year":"2016","journal-title":"J Intern Med"},{"key":"10.3233\/JAD-180152_ref21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-Mental State: Apractice method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-180152_ref22","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): Current versionand scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.3233\/JAD-180152_ref23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1037\/1040-3590.7.4.445","article-title":"Wechsler memory scale - revised","volume":"7","author":"Woodard","year":"1987","journal-title":"Psychol Assess"},{"key":"10.3233\/JAD-180152_ref24","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/gps.1375","article-title":"Development of initial validation of a15-item informant version of the Geriatric Depression Scale","volume":"20","author":"Brown","year":"2005","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-180152_ref25","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuroimage.2013.05.007","article-title":"Brain morphometry reproducibility in multi-center 3T MRI studies: A comparison of cross-sectional and longitudinal segmentations","volume":"83","author":"Jovicich","year":"2013","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180152_ref26","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1002\/hbm.22859","article-title":"Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European3T study on healthy elderly","volume":"36","author":"Marizzoni","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-180152_ref27","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.neuroimage.2014.06.075","article-title":"Multisite longitudinalreliability of tract-based spatial statistics in diffusion tensorimaging of healthy elderly subjects","volume":"101","author":"Jovicich","year":"2014","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180152_ref28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis: I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180152_ref29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating thehuman cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-180152_ref30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.3233\/JAD-180152_ref31","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180152_ref32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","article-title":"A computational atlas of the hippocampal formation using exvivo, ultra-high resolution MRI: Application to adaptive segmentation of MRI","volume":"115","author":"Iglesias","year":"2015","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180152_ref33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fninf.2014.00004","article-title":"DTIPrep: Quality control of diffusion-weighted images","volume":"8","author":"Oguz","year":"2014","journal-title":"Front Neuroinform"},{"key":"10.3233\/JAD-180152_ref34","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatialstatistics: Voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180152_ref35","doi-asserted-by":"crossref","first-page":"P1319","DOI":"10.1016\/j.jalz.2017.06.2024","article-title":"CSF biomarkers and effect of apolipoprotein E genotype, ageand sex on cut-off derivation in mild cognitive impairment","volume":"13","author":"Marizzoni","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180152_ref36","first-page":"409","article-title":"R: A language and environment forstatistical computing","volume":"1","author":"R Developement Core Team","year":"2015","journal-title":"R Found Stat Comput"},{"key":"10.3233\/JAD-180152_ref37","doi-asserted-by":"crossref","unstructured":"McLachlan G , Peel D (2000) Finite Mixture Models, John Wiley and Sons, New York.","DOI":"10.1002\/0471721182"},{"key":"10.3233\/JAD-180152_ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v018.i06","article-title":"Model-based methods ofclassification: Using the mclust software in chemometrics","volume":"18","author":"Fraley","year":"2007","journal-title":"J Stat Softw"},{"key":"10.3233\/JAD-180152_ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2517-6161.1977.tb01600.x","article-title":"Maximum likelihood fromincomplete data via the EM algorithm","volume":"39","author":"Dempster","year":"1977","journal-title":"J R Stat Soc Ser BMethodol"},{"key":"10.3233\/JAD-180152_ref40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00265-010-1029-6","article-title":"AIC model selection andmultimodel inference in behavioral ecology: Some background, observations, and comparisons","volume":"65","author":"Burnham","year":"2011","journal-title":"Behav Ecol Sociobiol"},{"key":"10.3233\/JAD-180152_ref41","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2307\/2533554","article-title":"Sample size calculations for studies with correlated observations","volume":"53","author":"Liu","year":"1997","journal-title":"Biometrics"},{"key":"10.3233\/JAD-180152_ref42","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1002\/hbm.21386","article-title":"Unbiased comparison of samplesize estimates from longitudinal structural measures in ADNI","volume":"33","author":"Holland","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-180152_ref43","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/brain\/awn146","article-title":"Ventricular enlargement as a possible measure of Alzheimer\u2019s disease progression validated using the Alzheimer\u2019s disease neuroimaging initiative database","volume":"131","author":"Nestor","year":"2008","journal-title":"Brain"},{"key":"10.3233\/JAD-180152_ref44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-160621","article-title":"Sample size estimation for Alzheimer\u2019s disease trials fromJapanese ADNI serial magnetic resonance imaging","volume":"56","author":"Fujishima","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-180152_ref45","doi-asserted-by":"crossref","first-page":"20954","DOI":"10.1073\/pnas.0906053106","article-title":"Subregional neuroanatomical change as a biomarker for Alzheimer\u2019sdisease","volume":"106","author":"Holland","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-180152_ref46","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1148\/radiol.11101975","article-title":"Mild cognitive impairment: Baseline and longitudinalstructural MR imaging measures improve predictive prognosis","volume":"259","author":"McEvoy","year":"2011","journal-title":"Radiology"},{"key":"10.3233\/JAD-180152_ref47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1001\/archneur.57.3.339","article-title":"Usingserial registered brain magnetic resonance imaging to measuredisease progression in Alzheimer disease - Power calculations andestimates of sample size to detect treatment effects","volume":"57","author":"Fox","year":"2000","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-180152_ref48","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1212\/01.WNL.0000110315.26026.EF","article-title":"Comparison of different MRI brain atrophy ratemeasures with clinical disease progression in AD","volume":"62","author":"Jack","year":"2004","journal-title":"Neurology"},{"key":"10.3233\/JAD-180152_ref49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1212\/01.wnl.0000167542.89697.0f","article-title":"Measuring atrophy in Alzheimer disease: A serial MRI study over 6and 12 months","volume":"65","author":"Schott","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-180152_ref50","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.neuroimage.2006.05.048","article-title":"Shape differences of the brain ventriclesin Alzheimer\u2019s disease","volume":"32","author":"Ferrarini","year":"2006","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180152_ref51","first-page":"1454","article-title":"Temporal horn index and volume of medial temporallobe atrophy using a new semiautomated method for rapid and precise assessment","volume":"27","author":"Giesel","year":"2006","journal-title":"Am J Neuroradiol"},{"key":"10.3233\/JAD-180152_ref52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1212\/01.wnl.0000172913.88973.0d","article-title":"Longitudinal volumetric MRI change and rate of cognitive decline","volume":"65","author":"Mungas","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-180152_ref53","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1212\/01.WNL.0000159743.08996.99","article-title":"Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease","volume":"64","author":"Fox","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-180152_ref54","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3233\/JAD-2010-1406","article-title":"Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer\u2019s disease","volume":"20","author":"Ott","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-180152_ref55","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1474-4422(03)00487-3","article-title":"Alzheimer\u2019s disease, normal-pressure hydrocephalus, and senescentchanges in CSF circulatory physiology: A hypothesis","volume":"2","author":"Silverberg","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-180152_ref56","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(97)09234-9","article-title":"Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged","volume":"351","author":"Rubenstein","year":"1998","journal-title":"Lancet"},{"key":"10.3233\/JAD-180152_ref57","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nn.2149","article-title":"A disproportionate role for the fornix andmammillary bodies in recall versus recognition memory","volume":"11","author":"Tsivilis","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.3233\/JAD-180152_ref58","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/JAD-2011-110557","article-title":"Which memory system is impaired first in alzheimer\u2019s disease?","volume":"27","author":"Didic","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-180152_ref59","first-page":"109","article-title":"Defining disease modifying therapy for Alzheimer\u2019s disease","volume":"4","author":"Cummings","year":"2017","journal-title":"J Prev Alzheimers Dis"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-180152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:29Z","timestamp":1777370969000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-180152"}},"subtitle":[],"editor":[{"given":"George","family":"Perry","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":59,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-180152","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]}}}