{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:29:56Z","timestamp":1776086996159,"version":"3.50.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,3,10]]},"DOI":"10.3233\/jad-190842","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T19:52:29Z","timestamp":1581105149000},"page":"227-235","source":"Crossref","is-referenced-by-count":25,"title":["Longer Duration of Hypertension and MRI Microvascular Brain Alterations Are Associated with Lower Hippocampal Volumes in Older Individuals with Hypertension"],"prefix":"10.1177","volume":"74","author":[{"given":"Areti","family":"Triantafyllou","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine and Memory Clinic, CMRR Nancy-Lorraine CHU-Nancy, Nancy, France"}]},{"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France"},{"name":"Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Masatake","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France"}]},{"given":"Emilien","family":"Micard","sequence":"additional","affiliation":[{"name":"CHRU-Nancy, Inserm, Universit\u00e9 de Lorraine, CIC, Innovation Technologique, Nancy, France"}]},{"given":"Yu","family":"Xie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, IADI, F-54000 Nancy, France"}]},{"given":"Anna","family":"Kearney-Schwartz","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine and Memory Clinic, CMRR Nancy-Lorraine CHU-Nancy, Nancy, France"}]},{"given":"Gabriela","family":"Hossu","sequence":"additional","affiliation":[{"name":"CHRU-Nancy, Inserm, Universit\u00e9 de Lorraine, CIC, Innovation Technologique, Nancy, France"},{"name":"Universit\u00e9 de Lorraine, Inserm, IADI, F-54000 Nancy, France"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France"}]},{"given":"Serge","family":"Bracard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, IADI, F-54000 Nancy, France"},{"name":"Department of Neuroradiology, CHU-Nancy, Nancy, France"}]},{"given":"Athanase","family":"Benetos","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine and Memory Clinic, CMRR Nancy-Lorraine CHU-Nancy, Nancy, France"},{"name":"INSERM, U1116, Universit\u00e9 de Lorraine, Vandoeuvre-les-Nancy, France"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-190842_ref1","doi-asserted-by":"crossref","first-page":"S495","DOI":"10.3233\/JAD-141419","article-title":"Characterizing early Alzheimer\u2019s disease and disease progression using hippocampal volume and arterial spin labeling perfusion MRI","volume":"42 Suppl 4","author":"Wang","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190842_ref2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1212\/01.wnl.0000344568.09360.31","article-title":"Hippocampal atrophy rates in Alzheimer disease: Added value over whole brain volume measures","volume":"72","author":"Henneman","year":"2009","journal-title":"Neurology"},{"key":"10.3233\/JAD-190842_ref3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fnagi.2014.00261","article-title":"A critical appraisal of the hippocampal subfield segmentation package in Freesurfer","volume":"6","author":"Wisse","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-190842_ref4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am J Roentgenol"},{"key":"10.3233\/JAD-190842_ref5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2217\/nmt.14.53","article-title":"Review of \u2018the potential role of arterial stiffness in the pathogenesis of Alzheimer\u2019s disease\u2019","volume":"5","author":"Hughes","year":"2015","journal-title":"Neurodegener Dis Manag"},{"key":"10.3233\/JAD-190842_ref6","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1212\/01.wnl.0000247046.90574.0f","article-title":"Body mass index in older persons is associated with Alzheimer disease pathology","volume":"67","author":"Buchman","year":"2006","journal-title":"Neurology"},{"key":"10.3233\/JAD-190842_ref7","doi-asserted-by":"crossref","first-page":"E108370","DOI":"10.1371\/journal.pone.0108370","article-title":"Improving retention of very old participants in longitudinal research: Experiences from the Newcastle 85+ Study","volume":"9","author":"Davies","year":"2014","journal-title":"PLoS One"},{"key":"10.3233\/JAD-190842_ref8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jamda.2017.01.008","article-title":"Memory alterations and white matter hyperintensities in elderly patients with hypertension: The ADELAHYDE-2 Study","volume":"18","author":"Ferreira","year":"2017","journal-title":"J Am Med Dir Assoc"},{"key":"10.3233\/JAD-190842_ref9","first-page":"S94","article-title":"Diabetic nephropathy","volume":"26 Suppl 1","author":"Molitch","year":"2003","journal-title":"Diabetes Care"},{"key":"10.3233\/JAD-190842_ref10","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1002\/hbm.22473","article-title":"Comparing manual and automatic segmentation of hippocampal volumes: Reliability and validity issues in younger and older brains","volume":"35","author":"Wenger","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-190842_ref11","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/jnnp.55.10.967","article-title":"Atrophy of medial temporal lobes on MRI in \u201cprobable\u201d Alzheimer\u2019s disease and normal ageing: Diagnostic value and neuropsychological correlates","volume":"55","author":"Scheltens","year":"1992","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-190842_ref12","first-page":"1483","article-title":"Normalization of cerebral volumes by use of intracranial volume: Implications for longitudinal quantitative MR imaging","volume":"22","author":"Whitwell","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.3233\/JAD-190842_ref13","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.STR.32.6.1318","article-title":"A new rating scale for age-related white matter changes applicable to MRI And CT","volume":"32","author":"Wahlund","year":"2001","journal-title":"Stroke"},{"key":"10.3233\/JAD-190842_ref14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1159\/000321120","article-title":"Association study of gene polymorphisms involved in vascular alterations in elderly hypertensives with subjective memory complaints","volume":"30","author":"Watfa","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-190842_ref15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/01.str.0000437068.30550.cf","article-title":"Factors influencing the decline in stroke mortality: A statement from the American Heart Association\/American Stroke Association","volume":"45","author":"Lackland","year":"2014","journal-title":"Stroke"},{"key":"10.3233\/JAD-190842_ref16","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/HYPERTENSIONAHA.113.01063","article-title":"Hypertension: A harbinger of stroke and dementia","volume":"62","author":"Faraco","year":"2013","journal-title":"Hypertension"},{"key":"10.3233\/JAD-190842_ref17","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.3233\/JAD-190842_ref18","first-page":"57","article-title":"Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: The HAAS. Honolulu-Asia Aging Study","volume":"21","author":"Petrovitch","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-190842_ref19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0022-510X(95)00105-B","article-title":"Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension","volume":"131","author":"Sparks","year":"1995","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-190842_ref20","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1161\/HYPERTENSIONAHA.111.182204","article-title":"Blood pressure trajectories from midlife to late life in relation to dementia in women followed for 37 years","volume":"59","author":"Joas","year":"2012","journal-title":"Hypertension"},{"key":"10.3233\/JAD-190842_ref21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/HYPERTENSIONAHA.114.03040","article-title":"Hypertension and dementia","volume":"64","author":"Iadecola","year":"2014","journal-title":"Hypertension"},{"key":"10.3233\/JAD-190842_ref22","doi-asserted-by":"crossref","first-page":"367516","DOI":"10.1155\/2012\/367516","article-title":"Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia","volume":"2012","author":"de la Torre","year":"2012","journal-title":"Cardiovasc Psychiatry Neurol"},{"key":"10.3233\/JAD-190842_ref23","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1161\/STROKEAHA.108.535245","article-title":"Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: The Framingham Study","volume":"40","author":"Romero","year":"2009","journal-title":"Stroke"},{"key":"10.3233\/JAD-190842_ref24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroscience.2012.05.060","article-title":"Cognitive functions of carotid artery stenosis in the aged rat","volume":"219","author":"Zhou","year":"2012","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-190842_ref25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/HYPERTENSIONAHA.117.09807","article-title":"Left ventricular mass, brain magnetic resonance imaging, and cognitive performance: Results from The Strong Heart Study","volume":"70","author":"Haring","year":"2017","journal-title":"Hypertension"},{"key":"10.3233\/JAD-190842_ref26","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1445-5994.2011.02645.x","article-title":"Arterial stiffness as a cause of cognitive decline and dementia: A systematic review and meta-analysis","volume":"42","author":"Pase","year":"2012","journal-title":"Intern Med J"},{"key":"10.3233\/JAD-190842_ref27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/HYPERTENSIONAHA.107.093674","article-title":"Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging","volume":"51","author":"Waldstein","year":"2008","journal-title":"Hypertension"},{"key":"10.3233\/JAD-190842_ref28","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/HJH.0000000000000954","article-title":"Arterial stiffness and medial temporal lobe atrophy in elders with memory disorders","volume":"34","author":"Lilamand","year":"2016","journal-title":"J Hypertens"},{"key":"10.3233\/JAD-190842_ref29","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1212\/01.wnl.0000435301.64776.37","article-title":"Pulse wave velocity is associated with beta-amyloid deposition in the brains of very elderly adults","volume":"81","author":"Hughes","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-190842_ref30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hbm.20870","article-title":"Brain structure and obesity","volume":"31","author":"Raji","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-190842_ref31","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1212\/01.wnl.0000306313.89165.ef","article-title":"Central obesity and increased risk of dementia more than three decades later","volume":"71","author":"Whitmer","year":"2008","journal-title":"Neurology"},{"key":"10.3233\/JAD-190842_ref32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/oby.2008.469","article-title":"Inverse association between BMI and prefrontal metabolic activity in healthy adults","volume":"17","author":"Volkow","year":"2009","journal-title":"Obesity"},{"key":"10.3233\/JAD-190842_ref33","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1212\/01.wnl.0000176061.33817.90","article-title":"Change in body mass index and risk of incident Alzheimer disease","volume":"65","author":"Buchman","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-190842_ref34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1017\/S1041610212001834","article-title":"Changes in body mass in later life and incident dementia","volume":"25","author":"Power","year":"2013","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-190842_ref35","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1212\/WNL.0b013e318238eec1","article-title":"Alzheimer disease biomarkers are associated with body mass index","volume":"77","author":"Vidoni","year":"2011","journal-title":"Neurology"},{"key":"10.3233\/JAD-190842_ref36","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.neuropsychologia.2004.04.006","article-title":"Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: Review and meta-analysis","volume":"42","author":"Van","year":"2004","journal-title":"Neuropsychologia"},{"key":"10.3233\/JAD-190842_ref37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2342-9-17","article-title":"Hippocampal volumes are important predictors for memory function in elderly women","volume":"9","author":"Ystad","year":"2009","journal-title":"BMC Med Imaging"},{"key":"10.3233\/JAD-190842_ref38","doi-asserted-by":"crossref","first-page":"101581","DOI":"10.1016\/j.nicl.2018.10.019","article-title":"A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants","volume":"21","author":"Khlif","year":"2019","journal-title":"Neuroimage Clin"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-190842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T20:41:23Z","timestamp":1741639283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-190842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":38,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-190842","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,10]]}}}