{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:15:47Z","timestamp":1777396547335,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,9,15]]},"abstract":"<jats:p>Background: The choroid plexus (CP), which constitutes the blood-cerebrospinal fluid barrier, was recently identified as an important component of the circadian clock system. Objective: The fact that circadian rhythm disruption is closely associated to Alzheimer\u2019s disease (AD) led us to investigate whether AD pathology can contribute to disturbances of the circadian clock in the CP. Methods: For this purpose, we evaluated the expression of core-clock genes at different time points, in 6- and 12-month-old female and male APP\/PS1 mouse models of AD. In addition, we also assessed the effect of melatonin pre-treatment in vitro before amyloid-\u03b2 stimulus in the daily pattern of brain and muscle Arnt-like protein 1 (Bmal1) expression. Results: Our results showed a dysregulation of circadian rhythmicity of Bmal1 expression in female and male APP\/PS1 transgenic 12-month-old mice and of Period 2 (Per2) expression in male mice. In addition, a significant circadian pattern of Bmal1 was measured the intermittent melatonin pre-treatment group, showing that melatonin can reset the CP circadian clock. Conclusion: These results demonstrated a connection between AD and the disruption of circadian rhythm in the CP, representing an attractive target for disease prevention and\/or treatment.<\/jats:p>","DOI":"10.3233\/jad-200331","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T12:57:51Z","timestamp":1596200271000},"page":"795-806","source":"Crossref","is-referenced-by-count":28,"title":["The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP\/PS1 Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"77","author":[{"given":"Andr\u00e9","family":"Furtado","sequence":"first","affiliation":[{"name":"CICS-UBI - Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Rosario","family":"Astaburuaga","sequence":"additional","affiliation":[{"name":"Institute for Theoretical Biology (ITB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt - Universit\u00e4t zu Berlin, Berlin Institute of Health, Germany"},{"name":"Medical Department of Hematology, Oncology, and Tumor Immunology and Molekulares Krebsforschungszentrum (MKFZ), Charit\u00e9 - Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt - Universit\u00e4t zu Berlin, Berlin Institute of Health, Germany"}]},{"given":"Ana","family":"Costa","sequence":"additional","affiliation":[{"name":"CICS-UBI - Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Ana C.","family":"Duarte","sequence":"additional","affiliation":[{"name":"CICS-UBI - Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Isabel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"CICS-UBI - Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Jos\u00e9","family":"Cipolla-Neto","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}]},{"given":"Manuel C.","family":"Lemos","sequence":"additional","affiliation":[{"name":"CICS-UBI - Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Eva","family":"Carro","sequence":"additional","affiliation":[{"name":"Networked Biomedical Research Center in Neurodegenerative Diseases (CIBERNED), Spain"},{"name":"Group of Neurodegenerative Diseases, Hospital 12 de Octubre Research Institute (imas12), Madrid, Spain"}]},{"given":"Angela","family":"Rel\u00f3gio","sequence":"additional","affiliation":[{"name":"Institute for Theoretical Biology (ITB), Charit\u00e9 - Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt - Universit\u00e4t zu 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