{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:16:28Z","timestamp":1777392988158,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:p>Background: Vascular cognitive impairment is frequent, in mild (mVCI) or severe forms (vascular dementia). Objective: To do a randomized controlled-trial to evaluate the impact of physical activity on cognition (primary outcome), neurocognitive measures, quality of life, functional status, and physical function (secondary outcomes), in patients with mVCI. Methods: A hundred and four patients with mVCI (mean age 71.2 years; 53 women) were randomized for a six-month intervention of moderate physical activity (60-minute sessions, 3 times\/week) (n\u200a=\u200a53) or best-practice \u201cusual care\u201d (n\u200a=\u200a51). Comprehensive evaluations of primary and secondary outcomes included an objective measure of physical activity through accelerometry at baseline and after intervention. Results: Mean session attendance was 58%. Adverse events were negligible. After 6 months, no significant primary outcome change was observed, either in the intervention or \u2018usual care\u2019 group. The intervention group improved significantly in some secondary outcomes in physical function - aerobic capacity (U\u200a=\u200a403; p\u200a=\u200a0.000) and agility (U\u200a=\u200a453; p\u200a=\u200a0.005) after 6 months. Regardless of randomization arm, a post-hoc analysis based on fulfilling at least 21.5 minutes\/day of moderate or 10.7 minutes\/day of vigorous physical activity (World Health Organization-WHO standards) revealed improvements. These were not only in motor capacity but also on the global measure of cognition, executive functions and memory. Conclusions: Physical activity was safe and beneficial regarding domains of physical function. No significant cognitive decline was registered over 6-months, regardless of intervention allocation. Larger samples, longer follow-ups and focus on intervention adherence are needed to fully analyze the impact of WHO recommendations for physical activity in mVCI populations.<\/jats:p>","DOI":"10.3233\/jad-240246","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T11:33:21Z","timestamp":1726227201000},"page":"1379-1392","source":"Crossref","is-referenced-by-count":1,"title":["Physical Activity in Mild Vascular Cognitive Impairment: Results of the AFIVASC Randomized Controlled Trial at 6 Months"],"prefix":"10.1177","volume":"101","author":[{"given":"Ana","family":"Verdelho","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Mental Health, Hospital de Santa Maria, Unidade de Sa\u00fade Local de Santa Maria, Centro de Estudos Egas Moniz, Instituto de Sa\u00fade Ambiental \u2013 ISAMB, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Manuel","family":"Correia","sequence":"additional","affiliation":[{"name":"Neurology Service, Hospital de Santo Ant\u00f3nio, Unidade Local de Sa\u00fade de Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio and Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade of Porto, Porto, Portugal"}]},{"given":"Manuel","family":"Gon\u00e7alves-Pereira","sequence":"additional","affiliation":[{"name":"NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, CHRC, Associate Laboratory REAL (LA-REAL), Lisbon, Portugal"}]},{"given":"Sofia","family":"Madureira","sequence":"additional","affiliation":[{"name":"Instituto Medicina Molecular Jo\u00e3o Lobo Antunes (IMM), Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Pedro","family":"Vilela","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Hospital da Luz, Lisbon, Portugal"}]},{"given":"Ana Catarina","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital do Mar, Bobadela, Lisbon, Portugal"}]},{"given":"M\u00e1rio","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade Ambiental \u2013 ISAMB, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Mariana","family":"Borges","sequence":"additional","affiliation":[{"name":"Instituto Medicina Molecular Jo\u00e3o Lobo Antunes (IMM), Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Jos\u00e9 M.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Helena","family":"Santa-Clara","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, Faculdade de Motricidade Humana, Centro Interdisciplinar de Estudo da Performance Humana \u2013 CIPER, Universidade de Lisboa, Lisbon, Portugal"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-240246_ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13195-016-0188-8","article-title":"Recent global trends in the prevalence and incidence of dementia, and survival with dementia","volume":"8","author":"Prince","year":"2016","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-240246_ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.3233\/JAD-240246_ref3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s13311-021-01170-y","article-title":"Vascular cognitive impairment (VCI)","volume":"19","author":"Rundek","year":"2022","journal-title":"Neurotherapeutics"},{"key":"10.3233\/JAD-240246_ref4","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1016\/j.jacc.2019.04.034","article-title":"Vascular cognitive impairment and dementia: JACC Scientific Expert Panel","volume":"73","author":"Iadecola","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.3233\/JAD-240246_ref5","volume-title":"World Alzheimer Report 2022. Life after diagnosis: Navigating treatment, care and support","author":"Gauthier","year":"2022"},{"key":"10.3233\/JAD-240246_ref6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/17474930211073387","article-title":"Diagnosing vascular cognitive impairment: Current challenges and future perspectives","volume":"18","author":"Biesbroek","year":"2023","journal-title":"Int J Stroke"},{"key":"10.3233\/JAD-240246_ref7","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1161\/STROKEAHA.112.651778","article-title":"Prevention of vascular cognitive impairment","volume":"43","author":"Dichgans","year":"2012","journal-title":"Stroke"},{"key":"10.3233\/JAD-240246_ref8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cger.2022.07.007","article-title":"The role of vascular risk factors in cognitive impairment and dementia and prospects for prevention","volume":"39","author":"Mahinrad","year":"2023","journal-title":"Clin Geriatr Med"},{"key":"10.3233\/JAD-240246_ref9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/HCO.0000000000000437","article-title":"Health benefits of physical activity: a systematic review of current systematic reviews","volume":"32","author":"Warburton","year":"2017","journal-title":"Curr Opin Cardiol"},{"key":"10.3233\/JAD-240246_ref11","doi-asserted-by":"crossref","first-page":"e0278226","DOI":"10.1371\/journal.pone.0278226","article-title":"Effect of physical activity on the risk of frailty: A systematic review and meta-analysis","volume":"17","author":"Zhao","year":"2022","journal-title":"PLoS One"},{"key":"10.3233\/JAD-240246_ref12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1136\/bjsports-2021-104981","article-title":"Physical activity as a protective factor for dementia and Alzheimer\u2019s disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies","volume":"56","author":"Iso-Markku","year":"2022","journal-title":"Br J Sports Med"},{"key":"10.3233\/JAD-240246_ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/brainsci7020022","article-title":"Physical activity: a viable way to reduce the risks of mild cognitive impairment, Alzheimer\u2019s disease, and vascular dementia in older adults","volume":"7","author":"Gallaway","year":"2017","journal-title":"Brain Sci"},{"key":"10.3233\/JAD-240246_ref14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/brain\/awv407","article-title":"Can physical exercise in old age improve memory and hippocampal function?","volume":"139","author":"Duzel","year":"2016","journal-title":"Brain"},{"key":"10.3233\/JAD-240246_ref16","doi-asserted-by":"crossref","first-page":"9016924","DOI":"10.1155\/2017\/9016924","article-title":"Impact of physical activity on cognitive decline, dementia, and its subtypes: meta-analysis of prospective studies","volume":"2017","author":"Guure","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.3233\/JAD-240246_ref17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13063-019-3174-1","article-title":"Impact of physical activity in vascular cognitive impairment (AFIVASC): study protocol for a randomised controlled trial","volume":"20","author":"Verdelho","year":"2019","journal-title":"Trials"},{"key":"10.3233\/JAD-240246_ref18","doi-asserted-by":"crossref","first-page":"c869","DOI":"10.1136\/bmj.c869","article-title":"CONSORT explanation and elaboration: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Moher","year":"2010","journal-title":"BMJ"},{"key":"10.3233\/JAD-240246_ref19","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.3233\/JAD-240246_ref20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.3233\/JAD-240246_ref21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/003693305700200504","article-title":"Cerebral vascular accidents in patients over the age of 60","volume":"2","author":"Rankin","year":"1957","journal-title":"II. Prognosis. Scott Med J"},{"key":"10.3233\/JAD-240246_ref22","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/01.STR.20.6.828","article-title":"Interobserver agreement for the assessment of handicap in stroke patients","volume":"20","author":"Bamford","year":"1989","journal-title":"Stroke"},{"key":"10.3233\/JAD-240246_ref23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/JAD-215381","article-title":"Physical activity self-report is not reliable among subjects with mild vascular cognitive impairment: The AFIVASC Study","volume":"87","author":"Verdelho","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-240246_ref24","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-240246_ref25","unstructured":"Garcia C . Alzheimer disease: clinical diagnosis issues. PhD Thesis, University of Lisbon, Portugal, 1984. http:\/\/hdl.handle.net\/10451\/4451."},{"key":"10.3233\/JAD-240246_ref26","first-page":"1981","volume-title":"Wechsler adult intelligence scale-revised (WAIS-R). Test Review: Manual for the Wechsler Adult Intelligence Scale-Revised","author":"Wechsler"},{"key":"10.3233\/JAD-240246_ref27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/arclin\/act001","article-title":"Semantic fluency and phonemic fluency: regression-based norms for the Portuguese population","volume":"28","author":"Cavaco","year":"2013","journal-title":"Arch Clin Neuropsychol"},{"key":"10.3233\/JAD-240246_ref28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","article-title":"The validity of the Trail Making Test as an indicator of organic brain damage","volume":"8","author":"Reitan","year":"1958","journal-title":"Percep Mot Skills"},{"key":"10.3233\/JAD-240246_ref29","first-page":"1997","volume-title":"Wechsler adult intelligence scale. Wechsler Adult Intelligence Scale-III","author":"Wechsler"},{"key":"10.3233\/JAD-240246_ref30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions","volume":"18","author":"Stroop","year":"1935","journal-title":"J Exp Psychol"},{"key":"10.3233\/JAD-240246_ref31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/13854049608406686","article-title":"A nine-word dementia version of the California Verbal Learning Test","volume":"10","author":"Libon","year":"1996","journal-title":"Clin Neuropsychol"},{"key":"10.3233\/JAD-240246_ref32","first-page":"1987","volume-title":"Wechsler memory scale-revised","author":"Wechsler"},{"key":"10.3233\/JAD-240246_ref33","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer\u2019s disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am J Psychiatry"},{"key":"10.3233\/JAD-240246_ref34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-240246_ref35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1300\/J018v05n01_09","article-title":"Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version","volume":"5","author":"Sheikh","year":"1986","journal-title":"Clin Gerontol"},{"key":"10.3233\/JAD-240246_ref36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jad.2018.07.038","article-title":"Clinical utility of the 15-item geriatric depression scale (GDS-15) for use with young and middle-aged adults","volume":"241","author":"Guerin","year":"2018","journal-title":"J Affect Disord"},{"key":"10.3233\/JAD-240246_ref37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-1781(91)90040-V","article-title":"Reliability and validity of the Apathy Evaluation Scale","volume":"38","author":"Marin","year":"1991","journal-title":"Psychiatry Res"},{"key":"10.3233\/JAD-240246_ref38","first-page":"266","article-title":"Metric properties of the portuguese version of the apathy evaluation scale","volume":"13","author":"Caeiro","year":"2012","journal-title":"Psicol Sa\u00fade Doen\u00e7as"},{"key":"10.3233\/JAD-240246_ref39","doi-asserted-by":"crossref","unstructured":"EuroQol\u2013a new facility for the measurement of health-related quality of life. Health Policy 1990; 16: 199\u2013208.","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"10.3233\/JAD-240246_ref40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/00006842-200205000-00016","article-title":"Assessing quality of life in older adults with cognitive impairment","volume":"64","author":"Logsdon","year":"2002","journal-title":"Psychosom Med"},{"key":"10.3233\/JAD-240246_ref41","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1017\/S1041610213000379","article-title":"Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer\u2019s Disease scale in Portugal","volume":"25","author":"B\u00e1rrios","year":"2013","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-240246_ref42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1249\/mss.0b013e31815a51b3","article-title":"Physical activity in the United States measured by accelerometer","volume":"40","author":"Troiano","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.3233\/JAD-240246_ref43","first-page":"63","article-title":"Quality control and data reduction procedures for accelerometry-derived measures of physical activity","volume":"21","author":"Colley","year":"2010","journal-title":"Health Rep"},{"key":"10.3233\/JAD-240246_ref44","first-page":"2001","volume-title":"Senior Fitness Test Manual","author":"Rikli"},{"key":"10.3233\/JAD-240246_ref45","doi-asserted-by":"crossref","first-page":"M751","DOI":"10.1093\/gerona\/57.11.M751","article-title":"The 6-minute walk test in mobility-limited elders: what is being measured?","volume":"57","author":"Bean","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3233\/JAD-240246_ref46","first-page":"2001","volume-title":"Fallproof: a comprehensive balance and mobility program","author":"Rose"},{"key":"10.3233\/JAD-240246_ref47","first-page":"2020","volume-title":"RA language and environment for statistical computing","author":"Team"},{"key":"10.3233\/JAD-240246_ref48","first-page":"104","volume-title":"Borg\u2019s perceived exertion and pain scales","author":"Borg","year":"1998"},{"key":"10.3233\/JAD-240246_ref50","first-page":"2013","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association"},{"key":"10.3233\/JAD-240246_ref51","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/gps.4220","article-title":"Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study","volume":"30","author":"Frederiksen","year":"2015","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-240246_ref52","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1161\/STROKEAHA.112.661793","article-title":"Physical activity prevents progression for cognitive impairment and vascular dementia: results from the LADIS (Leukoaraiosis and Disability) study","volume":"43","author":"Verdelho","year":"2012","journal-title":"Stroke"},{"key":"10.3233\/JAD-240246_ref53","doi-asserted-by":"crossref","first-page":"afad011","DOI":"10.1093\/ageing\/afad011","article-title":"Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis","volume":"52","author":"Sharma","year":"2023","journal-title":"Age Ageing"},{"key":"10.3233\/JAD-240246_ref54","doi-asserted-by":"crossref","first-page":"e209267","DOI":"10.1212\/WNL.0000000000209267","article-title":"Clinical phenotypes associated with cerebral small vessel disease: an overview of systematic reviews","volume":"102","author":"Kancheva","year":"2024","journal-title":"Neurology"},{"key":"10.3233\/JAD-240246_ref55","doi-asserted-by":"crossref","first-page":"107133","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107133","article-title":"Physical activity in vascular cognitive impairment: Systematic review with meta-analysis","volume":"32","author":"V\u00edtor","year":"2023","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.3233\/JAD-240246_ref56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S2215-0366(20)30431-4","article-title":"Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis","volume":"8","author":"Clancy","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"10.3233\/JAD-240246_ref57","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s41999-023-00858-y","article-title":"Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline","volume":"14","author":"Veronese","year":"2023","journal-title":"Eur Geriatr Med"},{"key":"10.3233\/JAD-240246_ref58","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jamda.2020.08.031","article-title":"Physical activity and exercise in mild cognitive impairment and dementia: an umbrella review of intervention and observational studies","volume":"21","author":"Demurtas","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"10.3233\/JAD-240246_ref59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/bjsports-2016-096846","article-title":"Aerobic exercise promotes executive functions and impacts functional neural activity among older adults with vascular cognitive impairment","volume":"52","author":"Hsu","year":"2018","journal-title":"Br J Sports Med"},{"key":"10.3233\/JAD-240246_ref60","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pmedr.2017.05.007","article-title":"Adherence support strategies for exercise interventions in people with mild cognitive impairment and dementia: A systematic review","volume":"7","author":"Van der Wardt","year":"2017","journal-title":"Prev Med Rep"},{"key":"10.3233\/JAD-240246_ref61","doi-asserted-by":"crossref","first-page":"101139","DOI":"10.1016\/j.pmedr.2020.101139","article-title":"Adherence to exercise interventions in older people with mild cognitive impairment and dementia: A systematic review and meta-analysis","volume":"19","author":"Di Lorito","year":"2020","journal-title":"Prev Med Rep"},{"key":"10.3233\/JAD-240246_ref62","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1123\/jpah.2018-0340","article-title":"Prevalence and preferences of self-reported physical activity and nonsedentary behaviors in Portuguese adults","volume":"16","author":"Teixeira","year":"2019","journal-title":"J Phys Act Health"},{"key":"10.3233\/JAD-240246_ref63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10741-016-9584-1","article-title":"Adherence to recommended exercise guidelines in patients with heart failure","volume":"22","author":"Deka","year":"2017","journal-title":"Heart Fail Rev"},{"key":"10.3233\/JAD-240246_ref64","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12603-022-1749-0","article-title":"Association between accelerometer-measured light-intensity physical activity and cognitive function in older adults","volume":"26","author":"Hsiao","year":"2022","journal-title":"J Nutr Health Aging"},{"key":"10.3233\/JAD-240246_ref65","doi-asserted-by":"crossref","first-page":"e192745","DOI":"10.1001\/jamanetworkopen.2019.2745","article-title":"Association of accelerometer-measured light-intensity physical activity with brain volume: The Framingham Heart Study","volume":"2","author":"Spartano","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.3233\/JAD-240246_ref66","doi-asserted-by":"crossref","first-page":"e017211","DOI":"10.1136\/bmjopen-2017-017211","article-title":"A new model of exercise referral scheme in primary care: is the effect on adherence to physical activity sustainable in the long term? A 15-month randomised controlled trial","volume":"8","author":"Mart\u00edn-Borr\u00e0s","year":"2018","journal-title":"BMJ Open"},{"key":"10.3233\/JAD-240246_ref67","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1186\/s12877-022-03302-1","article-title":"Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis","volume":"22","author":"Venegas-Sanabria","year":"2022","journal-title":"BMC Geriatr"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-240246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:59:09Z","timestamp":1777370349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/JAD-240246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":64,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jad-240246","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]}}}